The Role of Adiposity in Cardiometabolic Traits: A Mendelian Randomization Analysis
Identifieur interne : 004448 ( Main/Exploration ); précédent : 004447; suivant : 004449The Role of Adiposity in Cardiometabolic Traits: A Mendelian Randomization Analysis
Auteurs : Tove Fall [Suède] ; Sara H Gg [Suède] ; Reedik M Gi [Royaume-Uni, Estonie] ; Alexander Ploner [Suède] ; Krista Fischer [Estonie] ; Momoko Horikoshi [Royaume-Uni] ; Antti-Pekka Sarin [Finlande] ; Gudmar Thorleifsson [Islande] ; Claes Ladenvall [Suède] ; Mart Kals [Estonie] ; Maris Kuningas [Pays-Bas] ; Harmen H. M. Draisma [Pays-Bas] ; Janina S. Ried [Allemagne] ; Natalie R. Van Zuydam [Royaume-Uni] ; Ville Huikari [Finlande] ; Massimo Mangino [Royaume-Uni] ; Emily Sonestedt [Suède] ; Beben Benyamin [Australie] ; Christopher P. Nelson [Royaume-Uni] ; Natalia V. Rivera [Italie, Pays-Bas] ; Kati Kristiansson [Finlande] ; Huei-Yi Shen [Finlande] ; Aki S. Havulinna [Finlande] ; Abbas Dehghan [Pays-Bas] ; Louise A. Donnelly [Royaume-Uni] ; Marika Kaakinen [Finlande] ; Marja-Liisa Nuotio [Finlande] ; Neil Robertson [Royaume-Uni] ; Renée F. A. G. De Bruijn [Pays-Bas] ; M. Arfan Ikram [Pays-Bas] ; Najaf Amin [Pays-Bas] ; Anthony J. Balmforth [Royaume-Uni] ; Peter S. Braund [Royaume-Uni] ; Alexander S. F. Doney [Royaume-Uni] ; Angela Döring [Allemagne] ; Paul Elliott [Royaume-Uni] ; T Nu Esko [Estonie] ; Oscar H. Franco [Pays-Bas] ; Solveig Gretarsdottir [Islande] ; Anna-Liisa Hartikainen [Finlande] ; Kauko Heikkil [Finlande] ; Karl-Heinz Herzig [Finlande] ; Hilma Holm [Islande] ; Jouke Jan Hottenga [Pays-Bas] ; Elina Hyppönen [Royaume-Uni] ; Thomas Illig [Allemagne] ; Aaron Isaacs [Pays-Bas] ; Bo Isomaa [Finlande] ; Lennart C. Karssen [Pays-Bas] ; Johannes Kettunen [Finlande] ; Wolfgang Koenig [Allemagne] ; Kari Kuulasmaa [Finlande] ; Tiina Laatikainen [Finlande] ; Jaana Laitinen [Finlande] ; Cecilia Lindgren [Royaume-Uni] ; Valeriya Lyssenko [Suède, Danemark] ; Esa L R [Finlande] ; Nigel W. Rayner [Royaume-Uni] ; Satu M Nnistö [Finlande] ; Anneli Pouta [Finlande] ; Wolfgang Rathmann [Allemagne] ; Fernando Rivadeneira [Pays-Bas] ; Aimo Ruokonen [Finlande] ; Markku J. Savolainen [Finlande] ; Eric J. G. Sijbrands [Pays-Bas] ; Kerrin S. Small [Royaume-Uni] ; Jan H. Smit [Pays-Bas] ; Valgerdur Steinthorsdottir [Islande] ; Ann-Christine Syv Nen [Suède] ; Anja Taanila [Finlande] ; Martin D. Tobin [Royaume-Uni] ; Andre G. Uitterlinden [Pays-Bas] ; Sara M. Willems [Pays-Bas] ; Gonneke Willemsen [Pays-Bas] ; Jacqueline Witteman [Pays-Bas] ; Markus Perola [Estonie, Finlande] ; Alun Evans [Royaume-Uni] ; Jean Ferrières [France] ; Jarmo Virtamo [Finlande] ; Frank Kee [Royaume-Uni] ; David-Alexandre Tregouet [France] ; Dominique Arveiler [France] ; Philippe Amouyel [France] ; Marco M. Ferrario [Italie] ; Paolo Brambilla [Italie] ; Alistair S. Hall [Royaume-Uni] ; Andrew C. Heath [États-Unis] ; Pamela A. F. Madden [États-Unis] ; Nicholas G. Martin [Australie] ; Grant W. Montgomery [Australie] ; John B. Whitfield [Australie] ; Antti Jula [Finlande] ; Paul Knekt [Finlande] ; Ben Oostra [Pays-Bas] ; Cornelia M. Van Duijn [Pays-Bas] ; Brenda W. J. H. Penninx [Pays-Bas] ; George Davey Smith [Royaume-Uni] ; Jaakko Kaprio [Finlande] ; Nilesh J. Samani [Royaume-Uni] ; Christian Gieger [Allemagne] ; Annette Peters [Allemagne] ; H.-Erich Wichmann [Allemagne] ; Dorret I. Boomsma [Pays-Bas] ; Eco J. C. De Geus [Pays-Bas] ; Tiinamaija Tuomi [Finlande] ; Chris Power [Royaume-Uni] ; Christopher J. Hammond [Royaume-Uni] ; Tim D. Spector [Royaume-Uni] ; Lars Lind [Suède] ; Marju Orho-Melander [Suède] ; Colin Neil Alexander Palmer [Royaume-Uni] ; Andrew D. Morris [Royaume-Uni] ; Leif Groop [Finlande, Suède] ; Marjo-Riitta J Rvelin [Finlande, Royaume-Uni] ; Veikko Salomaa [Finlande] ; Erkki Vartiainen [Finlande] ; Albert Hofman [Pays-Bas] ; Samuli Ripatti [Finlande, Royaume-Uni] ; Andres Metspalu [Estonie] ; Unnur Thorsteinsdottir [Islande] ; Kari Stefansson [Islande] ; Nancy L. Pedersen [Suède] ; Mark I. Mccarthy [Royaume-Uni] ; Erik Ingelsson [Suède, Royaume-Uni] ; Inga Prokopenko [Royaume-Uni]Source :
- PLoS Medicine [ 1549-1277 ] ; 2013.
Abstract
In this study, Prokopenko and colleagues provide novel evidence for causal relationship between adiposity and heart failure and increased liver enzymes using a Mendelian randomization study design.
Url:
DOI: 10.1371/journal.pmed.1001474
PubMed: 23824655
PubMed Central: 3692470
Affiliations:
- Allemagne, Australie, Danemark, Estonie, Finlande, France, Islande, Italie, Pays-Bas, Royaume-Uni, Suède, États-Unis
- Alsace (région administrative), Angleterre, Bade-Wurtemberg, Basse-Saxe, Bavière, District de Düsseldorf, District de Haute-Bavière, District de Tübingen, East Middle Sweden, Finlande occidentale, Grand Est, Grand Londres, Hauts-de-France, Hollande-Méridionale, Hollande-Septentrionale, Irlande du Nord, Lombardie, Midi-Pyrénées, Missouri (État), Nord-Pas-de-Calais, Occitanie (région administrative), Oxfordshire, Rhénanie-du-Nord-Westphalie, Svealand, Uusimaa, Yorkshire-et-Humber, Île-de-France
- Amsterdam, Düsseldorf, Hanovre, Helsinki, Leeds, Leyde, Lille, Londres, Milan, Munich, Oxford, Paris, Rotterdam, Saint-Louis (Missouri), Stockholm, Strasbourg, Toulouse, Turku, Ulm, Uppsala
- Université d'Helsinki, Université d'Oxford, Université d'Uppsala, Université de Leeds, École de médecine (Université Washington de Saint-Louis)
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Le document en format XML
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sort="Draisma, Harmen H M" uniqKey="Draisma H" first="Harmen H. M." last="Draisma">Harmen H. M. Draisma</name><affiliation wicri:level="3"><nlm:aff id="aff10"><addr-line>Department of Biological Psychology, VU University Amsterdam, Amsterdam, The Netherlands</addr-line></nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Biological Psychology, VU University Amsterdam, Amsterdam</wicri:regionArea><placeName><settlement type="city">Amsterdam</settlement><region nuts="2" type="province">Hollande-Septentrionale</region></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="aff11"><addr-line>The EMGO Institute for Health and Care Research, Amsterdam, The Netherlands</addr-line></nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>The EMGO Institute for Health and Care Research, Amsterdam</wicri:regionArea><placeName><settlement type="city">Amsterdam</settlement><region nuts="2" type="province">Hollande-Septentrionale</region></placeName></affiliation></author><author><name sortKey="Ried, Janina S" sort="Ried, Janina S" uniqKey="Ried J" first="Janina S." last="Ried">Janina S. Ried</name><affiliation wicri:level="1"><nlm:aff id="aff12"><addr-line>Institute of Genetic Epidemiology, Helmholtz Zentrum München—German Research Center for Environmental Health, Neuherberg, Germany</addr-line></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Institute of Genetic Epidemiology, Helmholtz Zentrum München—German Research Center for Environmental Health, Neuherberg</wicri:regionArea><wicri:noRegion>Neuherberg</wicri:noRegion><wicri:noRegion>Neuherberg</wicri:noRegion><wicri:noRegion>Neuherberg</wicri:noRegion></affiliation></author><author><name sortKey="Van Zuydam, Natalie R" sort="Van Zuydam, Natalie R" uniqKey="Van Zuydam N" first="Natalie R." last="Van Zuydam">Natalie R. Van Zuydam</name><affiliation wicri:level="1"><nlm:aff id="aff13"><addr-line>Medical Research Institute, Ninewells Hospital and Medical School, University of Dundee, Dundee, United Kingdom</addr-line></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Medical Research Institute, Ninewells Hospital and Medical School, University of Dundee, Dundee</wicri:regionArea><wicri:noRegion>Dundee</wicri:noRegion></affiliation></author><author><name sortKey="Huikari, Ville" sort="Huikari, Ville" uniqKey="Huikari V" first="Ville" last="Huikari">Ville Huikari</name><affiliation wicri:level="1"><nlm:aff id="aff14"><addr-line>Institute of Health Sciences, University of Oulu, Oulu, Finland</addr-line></nlm:aff><country xml:lang="fr">Finlande</country><wicri:regionArea>Institute of Health Sciences, University of Oulu, Oulu</wicri:regionArea><wicri:noRegion>Oulu</wicri:noRegion></affiliation></author><author><name sortKey="Mangino, Massimo" sort="Mangino, Massimo" uniqKey="Mangino M" first="Massimo" last="Mangino">Massimo Mangino</name><affiliation wicri:level="1"><nlm:aff id="aff15"><addr-line>Department of Twin Research and Genetic Epidemiology, King's College London, United Kingdom</addr-line></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Twin Research and Genetic Epidemiology, King's College London</wicri:regionArea><wicri:noRegion>King's College London</wicri:noRegion></affiliation></author><author><name sortKey="Sonestedt, Emily" sort="Sonestedt, Emily" uniqKey="Sonestedt E" first="Emily" last="Sonestedt">Emily Sonestedt</name><affiliation wicri:level="1"><nlm:aff id="aff16"><addr-line>Diabetes and Cardiovascular Diseases Genetic Epidemiology Research Unit, Department of Clinical Sciences, Skåne University Hospital, Lund University, Malmö, Sweden</addr-line></nlm:aff><country xml:lang="fr">Suède</country><wicri:regionArea>Diabetes and Cardiovascular Diseases Genetic Epidemiology Research Unit, Department of Clinical Sciences, Skåne University Hospital, Lund University, Malmö</wicri:regionArea><wicri:noRegion>Malmö</wicri:noRegion></affiliation></author><author><name sortKey="Benyamin, Beben" sort="Benyamin, Beben" uniqKey="Benyamin B" first="Beben" last="Benyamin">Beben Benyamin</name><affiliation wicri:level="1"><nlm:aff id="aff17"><addr-line>Queensland Institute of Medical Research, Herston, Australia</addr-line></nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Queensland Institute of Medical Research, Herston</wicri:regionArea><wicri:noRegion>Herston</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="aff18"><addr-line>Queensland Brain Institute, University of Queensland, St Lucia, Australia</addr-line></nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Queensland Brain Institute, University of Queensland, St Lucia</wicri:regionArea><wicri:noRegion>St Lucia</wicri:noRegion></affiliation></author><author><name sortKey="Nelson, Christopher P" sort="Nelson, Christopher P" uniqKey="Nelson C" first="Christopher P." last="Nelson">Christopher P. Nelson</name><affiliation wicri:level="1"><nlm:aff id="aff19"><addr-line>Department of Cardiovascular Sciences, University of Leicester, Leicester, United Kingdom</addr-line></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Cardiovascular Sciences, University of Leicester, Leicester</wicri:regionArea><wicri:noRegion>Leicester</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="aff20"><addr-line>National Institute for Health Research, Leicester Cardiovascular Biomedical Research Unit, Glenfield Hospital, Leicester, United Kingdom</addr-line></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>National Institute for Health Research, Leicester Cardiovascular Biomedical Research Unit, Glenfield Hospital, Leicester</wicri:regionArea><wicri:noRegion>Leicester</wicri:noRegion></affiliation></author><author><name sortKey="Rivera, Natalia V" sort="Rivera, Natalia V" uniqKey="Rivera N" first="Natalia V." last="Rivera">Natalia V. Rivera</name><affiliation wicri:level="3"><nlm:aff id="aff21"><addr-line>IRCSS Multimedica, Milan, Italy</addr-line></nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>IRCSS Multimedica, Milan</wicri:regionArea><placeName><settlement type="city">Milan</settlement><region nuts="2">Lombardie</region></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="aff22"><addr-line>Institute of Genetics and Biomedical Research, Consiglio Nazionale delle Ricerche, Milan, Italy</addr-line></nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Institute of Genetics and Biomedical Research, Consiglio Nazionale delle Ricerche, Milan</wicri:regionArea><placeName><settlement type="city">Milan</settlement><region nuts="2">Lombardie</region></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="aff23"><addr-line>Department of Genetic Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands</addr-line></nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Genetic Epidemiology, Erasmus Medical Center, Rotterdam</wicri:regionArea><placeName><settlement type="city">Rotterdam</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation></author><author><name sortKey="Kristiansson, Kati" sort="Kristiansson, Kati" uniqKey="Kristiansson K" first="Kati" last="Kristiansson">Kati Kristiansson</name><affiliation wicri:level="1"><nlm:aff id="aff24"><addr-line>Department of Chronic Disease Prevention, National Institute for Health and Welfare, Helsinki, Finland</addr-line></nlm:aff><country xml:lang="fr">Finlande</country><wicri:regionArea>Department of Chronic Disease Prevention, National Institute for Health and Welfare, Helsinki</wicri:regionArea><wicri:noRegion>Helsinki</wicri:noRegion></affiliation></author><author><name sortKey="Shen, Huei Yi" sort="Shen, Huei Yi" uniqKey="Shen H" first="Huei-Yi" last="Shen">Huei-Yi Shen</name><affiliation wicri:level="4"><nlm:aff id="aff6"><addr-line>Institute for Molecular Medicine Finland, University of Helsinki, Helsinki, Finland</addr-line></nlm:aff><country xml:lang="fr">Finlande</country><wicri:regionArea>Institute for Molecular Medicine Finland, University of Helsinki, Helsinki</wicri:regionArea><orgName type="university">Université d'Helsinki</orgName><placeName><settlement type="city">Helsinki</settlement><region type="région" nuts="2">Uusimaa</region></placeName></affiliation><affiliation wicri:level="1"><nlm:aff id="aff25"><addr-line>Public Health Genomics Unit, National Institute for Health and Welfare, Helsinki, Finland</addr-line></nlm:aff><country xml:lang="fr">Finlande</country><wicri:regionArea>Public Health Genomics Unit, National Institute for Health and Welfare, Helsinki</wicri:regionArea><wicri:noRegion>Helsinki</wicri:noRegion></affiliation></author><author><name sortKey="Havulinna, Aki S" sort="Havulinna, Aki S" uniqKey="Havulinna A" first="Aki S." last="Havulinna">Aki S. Havulinna</name><affiliation wicri:level="1"><nlm:aff id="aff24"><addr-line>Department of Chronic Disease Prevention, National Institute for Health and Welfare, Helsinki, Finland</addr-line></nlm:aff><country xml:lang="fr">Finlande</country><wicri:regionArea>Department of Chronic Disease Prevention, National Institute for Health and Welfare, Helsinki</wicri:regionArea><wicri:noRegion>Helsinki</wicri:noRegion></affiliation></author><author><name sortKey="Dehghan, Abbas" sort="Dehghan, Abbas" uniqKey="Dehghan A" first="Abbas" last="Dehghan">Abbas Dehghan</name><affiliation wicri:level="3"><nlm:aff id="aff9"><addr-line>Department of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands</addr-line></nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Epidemiology, Erasmus Medical Center, Rotterdam</wicri:regionArea><placeName><settlement type="city">Rotterdam</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="aff26"><addr-line>Netherlands Consortium for Healthy Ageing, Netherlands Genomics Initiative, Leiden, The Netherlands</addr-line></nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Netherlands Consortium for Healthy Ageing, Netherlands Genomics Initiative, Leiden</wicri:regionArea><placeName><settlement type="city">Leyde</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation></author><author><name sortKey="Donnelly, Louise A" sort="Donnelly, Louise A" uniqKey="Donnelly L" first="Louise A." last="Donnelly">Louise A. Donnelly</name><affiliation wicri:level="1"><nlm:aff id="aff13"><addr-line>Medical Research Institute, Ninewells Hospital and Medical School, University of Dundee, Dundee, United Kingdom</addr-line></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Medical Research Institute, Ninewells Hospital and Medical School, University of Dundee, Dundee</wicri:regionArea><wicri:noRegion>Dundee</wicri:noRegion></affiliation></author><author><name sortKey="Kaakinen, Marika" sort="Kaakinen, Marika" uniqKey="Kaakinen M" first="Marika" last="Kaakinen">Marika Kaakinen</name><affiliation wicri:level="1"><nlm:aff id="aff14"><addr-line>Institute of Health Sciences, University of Oulu, Oulu, Finland</addr-line></nlm:aff><country xml:lang="fr">Finlande</country><wicri:regionArea>Institute of Health Sciences, University of Oulu, Oulu</wicri:regionArea><wicri:noRegion>Oulu</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="aff27"><addr-line>Biocenter Oulu, University of Oulu, Oulu, Finland</addr-line></nlm:aff><country xml:lang="fr">Finlande</country><wicri:regionArea>Biocenter Oulu, University of Oulu, Oulu</wicri:regionArea><wicri:noRegion>Oulu</wicri:noRegion></affiliation></author><author><name sortKey="Nuotio, Marja Liisa" sort="Nuotio, Marja Liisa" uniqKey="Nuotio M" first="Marja-Liisa" last="Nuotio">Marja-Liisa Nuotio</name><affiliation wicri:level="1"><nlm:aff id="aff24"><addr-line>Department of Chronic Disease Prevention, National Institute for Health and Welfare, Helsinki, Finland</addr-line></nlm:aff><country xml:lang="fr">Finlande</country><wicri:regionArea>Department of Chronic Disease Prevention, National Institute for Health and Welfare, Helsinki</wicri:regionArea><wicri:noRegion>Helsinki</wicri:noRegion></affiliation></author><author><name sortKey="Robertson, Neil" sort="Robertson, Neil" uniqKey="Robertson N" first="Neil" last="Robertson">Neil Robertson</name><affiliation wicri:level="4"><nlm:aff id="aff3"><addr-line>Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom</addr-line></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford</wicri:regionArea><placeName><settlement type="city">Oxford</settlement><region type="country">Angleterre</region><region type="comté" nuts="2">Oxfordshire</region><settlement type="city">Oxford</settlement></placeName><orgName type="university">Université d'Oxford</orgName></affiliation><affiliation wicri:level="4"><nlm:aff id="aff5"><addr-line>Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Oxford, United Kingdom</addr-line></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Oxford</wicri:regionArea><placeName><settlement type="city">Oxford</settlement><region type="country">Angleterre</region><region type="comté" nuts="2">Oxfordshire</region><settlement type="city">Oxford</settlement></placeName><orgName type="university">Université d'Oxford</orgName></affiliation></author><author><name sortKey="De Bruijn, Renee F A G" sort="De Bruijn, Renee F A G" uniqKey="De Bruijn R" first="Renée F. A. G." last="De Bruijn">Renée F. A. G. De Bruijn</name><affiliation wicri:level="3"><nlm:aff id="aff9"><addr-line>Department of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands</addr-line></nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Epidemiology, Erasmus Medical Center, Rotterdam</wicri:regionArea><placeName><settlement type="city">Rotterdam</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="aff28"><addr-line>Department of Neurology, Erasmus Medical Center, Rotterdam, The Netherlands</addr-line></nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Neurology, Erasmus Medical Center, Rotterdam</wicri:regionArea><placeName><settlement type="city">Rotterdam</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation></author><author><name sortKey="Ikram, M Arfan" sort="Ikram, M Arfan" uniqKey="Ikram M" first="M. Arfan" last="Ikram">M. Arfan Ikram</name><affiliation wicri:level="3"><nlm:aff id="aff9"><addr-line>Department of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands</addr-line></nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Epidemiology, Erasmus Medical Center, Rotterdam</wicri:regionArea><placeName><settlement type="city">Rotterdam</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="aff28"><addr-line>Department of Neurology, Erasmus Medical Center, Rotterdam, The Netherlands</addr-line></nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Neurology, Erasmus Medical Center, Rotterdam</wicri:regionArea><placeName><settlement type="city">Rotterdam</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="aff29"><addr-line>Department of Radiology, Erasmus Medical Center, Rotterdam, The Netherlands</addr-line></nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Radiology, Erasmus Medical Center, Rotterdam</wicri:regionArea><placeName><settlement type="city">Rotterdam</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation></author><author><name sortKey="Amin, Najaf" sort="Amin, Najaf" uniqKey="Amin N" first="Najaf" last="Amin">Najaf Amin</name><affiliation wicri:level="3"><nlm:aff id="aff23"><addr-line>Department of Genetic Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands</addr-line></nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Genetic Epidemiology, Erasmus Medical Center, Rotterdam</wicri:regionArea><placeName><settlement type="city">Rotterdam</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation></author><author><name sortKey="Balmforth, Anthony J" sort="Balmforth, Anthony J" uniqKey="Balmforth A" first="Anthony J." last="Balmforth">Anthony J. Balmforth</name><affiliation wicri:level="4"><nlm:aff id="aff30"><addr-line>Division of Epidemiology, Leeds Institute of Genetics, Health and Therapeutics, School of Medicine, University of Leeds, Leeds, United Kingdom</addr-line></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Division of Epidemiology, Leeds Institute of Genetics, Health and Therapeutics, School of Medicine, University of Leeds, Leeds</wicri:regionArea><orgName type="university">Université de Leeds</orgName><placeName><settlement type="city">Leeds</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Yorkshire-et-Humber</region></placeName></affiliation></author><author><name sortKey="Braund, Peter S" sort="Braund, Peter S" uniqKey="Braund P" first="Peter S." last="Braund">Peter S. Braund</name><affiliation wicri:level="1"><nlm:aff id="aff19"><addr-line>Department of Cardiovascular Sciences, University of Leicester, Leicester, United Kingdom</addr-line></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Cardiovascular Sciences, University of Leicester, Leicester</wicri:regionArea><wicri:noRegion>Leicester</wicri:noRegion></affiliation></author><author><name sortKey="Doney, Alexander S F" sort="Doney, Alexander S F" uniqKey="Doney A" first="Alexander S. F." last="Doney">Alexander S. F. Doney</name><affiliation wicri:level="1"><nlm:aff id="aff13"><addr-line>Medical Research Institute, Ninewells Hospital and Medical School, University of Dundee, Dundee, United Kingdom</addr-line></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Medical Research Institute, Ninewells Hospital and Medical School, University of Dundee, Dundee</wicri:regionArea><wicri:noRegion>Dundee</wicri:noRegion></affiliation></author><author><name sortKey="Doring, Angela" sort="Doring, Angela" uniqKey="Doring A" first="Angela" last="Döring">Angela Döring</name><affiliation wicri:level="1"><nlm:aff id="aff31"><addr-line>Institute of Epidemiology I, Helmholtz Zentrum München—German Research Center for Environmental Health, Neuherberg, Germany</addr-line></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Institute of Epidemiology I, Helmholtz Zentrum München—German Research Center for Environmental Health, Neuherberg</wicri:regionArea><wicri:noRegion>Neuherberg</wicri:noRegion><wicri:noRegion>Neuherberg</wicri:noRegion><wicri:noRegion>Neuherberg</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="aff32"><addr-line>Institute of Epidemiology II, Helmholtz Zentrum München—German Research Center for Environmental Health, Neuherberg, Germany</addr-line></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Institute of Epidemiology II, Helmholtz Zentrum München—German Research Center for Environmental Health, Neuherberg</wicri:regionArea><wicri:noRegion>Neuherberg</wicri:noRegion><wicri:noRegion>Neuherberg</wicri:noRegion><wicri:noRegion>Neuherberg</wicri:noRegion></affiliation></author><author><name sortKey="Elliott, Paul" sort="Elliott, Paul" uniqKey="Elliott P" first="Paul" last="Elliott">Paul Elliott</name><affiliation wicri:level="3"><nlm:aff id="aff33"><addr-line>MRC-HPA Centre for Environment and Health, Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, United Kingdom</addr-line></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>MRC-HPA Centre for Environment and Health, Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Esko, T Nu" sort="Esko, T Nu" uniqKey="Esko T" first="T Nu" last="Esko">T Nu Esko</name><affiliation wicri:level="1"><nlm:aff id="aff4"><addr-line>Estonian Genome Center, University of Tartu, Tartu, Estonia</addr-line></nlm:aff><country xml:lang="fr">Estonie</country><wicri:regionArea>Estonian Genome Center, University of Tartu, Tartu</wicri:regionArea><wicri:noRegion>Tartu</wicri:noRegion></affiliation></author><author><name sortKey="Franco, Oscar H" sort="Franco, Oscar H" uniqKey="Franco O" first="Oscar H." last="Franco">Oscar H. Franco</name><affiliation wicri:level="3"><nlm:aff id="aff9"><addr-line>Department of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands</addr-line></nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Epidemiology, Erasmus Medical Center, Rotterdam</wicri:regionArea><placeName><settlement type="city">Rotterdam</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="aff26"><addr-line>Netherlands Consortium for Healthy Ageing, Netherlands Genomics Initiative, Leiden, The Netherlands</addr-line></nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Netherlands Consortium for Healthy Ageing, Netherlands Genomics Initiative, Leiden</wicri:regionArea><placeName><settlement type="city">Leyde</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation></author><author><name sortKey="Gretarsdottir, Solveig" sort="Gretarsdottir, Solveig" uniqKey="Gretarsdottir S" first="Solveig" last="Gretarsdottir">Solveig Gretarsdottir</name><affiliation wicri:level="1"><nlm:aff id="aff7"><addr-line>deCODE Genetics, Reykjavik, Iceland</addr-line></nlm:aff><country xml:lang="fr">Islande</country><wicri:regionArea>deCODE Genetics, Reykjavik</wicri:regionArea><wicri:noRegion>Reykjavik</wicri:noRegion></affiliation></author><author><name sortKey="Hartikainen, Anna Liisa" sort="Hartikainen, Anna Liisa" uniqKey="Hartikainen A" first="Anna-Liisa" last="Hartikainen">Anna-Liisa Hartikainen</name><affiliation wicri:level="1"><nlm:aff id="aff34"><addr-line>Department of Obstetrics and Gynaecology, Institute of Clinical Sciences, University of Oulu, Oulu, Finland</addr-line></nlm:aff><country xml:lang="fr">Finlande</country><wicri:regionArea>Department of Obstetrics and Gynaecology, Institute of Clinical Sciences, University of Oulu, Oulu</wicri:regionArea><wicri:noRegion>Oulu</wicri:noRegion></affiliation></author><author><name sortKey="Heikkil, Kauko" sort="Heikkil, Kauko" uniqKey="Heikkil K" first="Kauko" last="Heikkil">Kauko Heikkil</name><affiliation wicri:level="4"><nlm:aff id="aff35"><addr-line>Department of Public Health, Hjelt Institute, University of Helsinki, Helsinki, Finland</addr-line></nlm:aff><country xml:lang="fr">Finlande</country><wicri:regionArea>Department of Public Health, Hjelt Institute, University of Helsinki, Helsinki</wicri:regionArea><orgName type="university">Université d'Helsinki</orgName><placeName><settlement type="city">Helsinki</settlement><region type="région" nuts="2">Uusimaa</region></placeName></affiliation></author><author><name sortKey="Herzig, Karl Heinz" sort="Herzig, Karl Heinz" uniqKey="Herzig K" first="Karl-Heinz" last="Herzig">Karl-Heinz Herzig</name><affiliation wicri:level="1"><nlm:aff id="aff27"><addr-line>Biocenter Oulu, University of Oulu, Oulu, Finland</addr-line></nlm:aff><country xml:lang="fr">Finlande</country><wicri:regionArea>Biocenter Oulu, University of Oulu, Oulu</wicri:regionArea><wicri:noRegion>Oulu</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="aff36"><addr-line>Institute of Biomedicine, University of Oulu, Oulu, Finland</addr-line></nlm:aff><country xml:lang="fr">Finlande</country><wicri:regionArea>Institute of Biomedicine, University of Oulu, Oulu</wicri:regionArea><wicri:noRegion>Oulu</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="aff37"><addr-line>Department of Psychiatry, Kuopio University Hospital, Kuopio, Finland</addr-line></nlm:aff><country xml:lang="fr">Finlande</country><wicri:regionArea>Department of Psychiatry, Kuopio University Hospital, Kuopio</wicri:regionArea><wicri:noRegion>Kuopio</wicri:noRegion></affiliation></author><author><name sortKey="Holm, Hilma" sort="Holm, Hilma" uniqKey="Holm H" first="Hilma" last="Holm">Hilma Holm</name><affiliation wicri:level="1"><nlm:aff id="aff7"><addr-line>deCODE Genetics, Reykjavik, Iceland</addr-line></nlm:aff><country xml:lang="fr">Islande</country><wicri:regionArea>deCODE Genetics, Reykjavik</wicri:regionArea><wicri:noRegion>Reykjavik</wicri:noRegion></affiliation></author><author><name sortKey="Hottenga, Jouke Jan" sort="Hottenga, Jouke Jan" uniqKey="Hottenga J" first="Jouke Jan" last="Hottenga">Jouke Jan Hottenga</name><affiliation wicri:level="3"><nlm:aff id="aff10"><addr-line>Department of Biological Psychology, VU University Amsterdam, Amsterdam, The Netherlands</addr-line></nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Biological Psychology, VU University Amsterdam, Amsterdam</wicri:regionArea><placeName><settlement type="city">Amsterdam</settlement><region nuts="2" type="province">Hollande-Septentrionale</region></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="aff11"><addr-line>The EMGO Institute for Health and Care Research, Amsterdam, The Netherlands</addr-line></nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>The EMGO Institute for Health and Care Research, Amsterdam</wicri:regionArea><placeName><settlement type="city">Amsterdam</settlement><region nuts="2" type="province">Hollande-Septentrionale</region></placeName></affiliation></author><author><name sortKey="Hypponen, Elina" sort="Hypponen, Elina" uniqKey="Hypponen E" first="Elina" last="Hyppönen">Elina Hyppönen</name><affiliation wicri:level="3"><nlm:aff id="aff38"><addr-line>Centre for Paediatric Epidemiology and Biostatistics and Medical Research Council Centre for the Epidemiology of Child Health, University College London Institute of Child Health, London, United Kingdom</addr-line></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Centre for Paediatric Epidemiology and Biostatistics and Medical Research Council Centre for the Epidemiology of Child Health, University College London Institute of Child Health, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Illig, Thomas" sort="Illig, Thomas" uniqKey="Illig T" first="Thomas" last="Illig">Thomas Illig</name><affiliation wicri:level="3"><nlm:aff id="aff39"><addr-line>Hannover Unified Biobank, Hannover Medical School, Hannover, Germany</addr-line></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Hannover Unified Biobank, Hannover Medical School, Hannover</wicri:regionArea><placeName><region type="land" nuts="2">Basse-Saxe</region><settlement type="city">Hanovre</settlement></placeName></affiliation><affiliation wicri:level="1"><nlm:aff id="aff40"><addr-line>Research Unit of Molecular Epidemiology, Helmholtz Zentrum München—German Research Center for Environmental Health, Neuherberg, Germany</addr-line></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Research Unit of Molecular Epidemiology, Helmholtz Zentrum München—German Research Center for Environmental Health, Neuherberg</wicri:regionArea><wicri:noRegion>Neuherberg</wicri:noRegion><wicri:noRegion>Neuherberg</wicri:noRegion><wicri:noRegion>Neuherberg</wicri:noRegion></affiliation></author><author><name sortKey="Isaacs, Aaron" sort="Isaacs, Aaron" uniqKey="Isaacs A" first="Aaron" last="Isaacs">Aaron Isaacs</name><affiliation wicri:level="3"><nlm:aff id="aff23"><addr-line>Department of Genetic Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands</addr-line></nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Genetic Epidemiology, Erasmus Medical Center, Rotterdam</wicri:regionArea><placeName><settlement type="city">Rotterdam</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation></author><author><name sortKey="Isomaa, Bo" sort="Isomaa, Bo" uniqKey="Isomaa B" first="Bo" last="Isomaa">Bo Isomaa</name><affiliation wicri:level="1"><nlm:aff id="aff41"><addr-line>Department of Social Services and Health Care, Jakobstad, Finland</addr-line></nlm:aff><country xml:lang="fr">Finlande</country><wicri:regionArea>Department of Social Services and Health Care, Jakobstad</wicri:regionArea><wicri:noRegion>Jakobstad</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="aff42"><addr-line>Folkhälsan Research Centre, Helsinki, Finland</addr-line></nlm:aff><country xml:lang="fr">Finlande</country><wicri:regionArea>Folkhälsan Research Centre, Helsinki</wicri:regionArea><wicri:noRegion>Helsinki</wicri:noRegion></affiliation></author><author><name sortKey="Karssen, Lennart C" sort="Karssen, Lennart C" uniqKey="Karssen L" first="Lennart C." last="Karssen">Lennart C. Karssen</name><affiliation wicri:level="3"><nlm:aff id="aff23"><addr-line>Department of Genetic Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands</addr-line></nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Genetic Epidemiology, Erasmus Medical Center, Rotterdam</wicri:regionArea><placeName><settlement type="city">Rotterdam</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation></author><author><name sortKey="Kettunen, Johannes" sort="Kettunen, Johannes" uniqKey="Kettunen J" first="Johannes" last="Kettunen">Johannes Kettunen</name><affiliation wicri:level="4"><nlm:aff id="aff6"><addr-line>Institute for Molecular Medicine Finland, University of Helsinki, Helsinki, Finland</addr-line></nlm:aff><country xml:lang="fr">Finlande</country><wicri:regionArea>Institute for Molecular Medicine Finland, University of Helsinki, Helsinki</wicri:regionArea><orgName type="university">Université d'Helsinki</orgName><placeName><settlement type="city">Helsinki</settlement><region type="région" nuts="2">Uusimaa</region></placeName></affiliation><affiliation wicri:level="1"><nlm:aff id="aff24"><addr-line>Department of Chronic Disease Prevention, National Institute for Health and Welfare, Helsinki, Finland</addr-line></nlm:aff><country xml:lang="fr">Finlande</country><wicri:regionArea>Department of Chronic Disease Prevention, National Institute for Health and Welfare, Helsinki</wicri:regionArea><wicri:noRegion>Helsinki</wicri:noRegion></affiliation></author><author><name sortKey="Koenig, Wolfgang" sort="Koenig, Wolfgang" uniqKey="Koenig W" first="Wolfgang" last="Koenig">Wolfgang Koenig</name><affiliation wicri:level="3"><nlm:aff id="aff43"><addr-line>Department of Internal Medicine II–Cardiology, University of Ulm Medical Center, Ulm, Germany</addr-line></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Internal Medicine II–Cardiology, University of Ulm Medical Center, Ulm</wicri:regionArea><placeName><region type="land" nuts="1">Bade-Wurtemberg</region><region type="district" nuts="2">District de Tübingen</region><settlement type="city">Ulm</settlement></placeName></affiliation></author><author><name sortKey="Kuulasmaa, Kari" sort="Kuulasmaa, Kari" uniqKey="Kuulasmaa K" first="Kari" last="Kuulasmaa">Kari Kuulasmaa</name><affiliation wicri:level="1"><nlm:aff id="aff24"><addr-line>Department of Chronic Disease Prevention, National Institute for Health and Welfare, Helsinki, Finland</addr-line></nlm:aff><country xml:lang="fr">Finlande</country><wicri:regionArea>Department of Chronic Disease Prevention, National Institute for Health and Welfare, Helsinki</wicri:regionArea><wicri:noRegion>Helsinki</wicri:noRegion></affiliation></author><author><name sortKey="Laatikainen, Tiina" sort="Laatikainen, Tiina" uniqKey="Laatikainen T" first="Tiina" last="Laatikainen">Tiina Laatikainen</name><affiliation wicri:level="1"><nlm:aff id="aff24"><addr-line>Department of Chronic Disease Prevention, National Institute for Health and Welfare, Helsinki, Finland</addr-line></nlm:aff><country xml:lang="fr">Finlande</country><wicri:regionArea>Department of Chronic Disease Prevention, National Institute for Health and Welfare, Helsinki</wicri:regionArea><wicri:noRegion>Helsinki</wicri:noRegion></affiliation></author><author><name sortKey="Laitinen, Jaana" sort="Laitinen, Jaana" uniqKey="Laitinen J" first="Jaana" last="Laitinen">Jaana Laitinen</name><affiliation wicri:level="1"><nlm:aff id="aff44"><addr-line>Finnish Institute of Occupational Health, Helsinki, Finland</addr-line></nlm:aff><country xml:lang="fr">Finlande</country><wicri:regionArea>Finnish Institute of Occupational Health, Helsinki</wicri:regionArea><wicri:noRegion>Helsinki</wicri:noRegion></affiliation></author><author><name sortKey="Lindgren, Cecilia" sort="Lindgren, Cecilia" uniqKey="Lindgren C" first="Cecilia" last="Lindgren">Cecilia Lindgren</name><affiliation wicri:level="4"><nlm:aff id="aff3"><addr-line>Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom</addr-line></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford</wicri:regionArea><placeName><settlement type="city">Oxford</settlement><region type="country">Angleterre</region><region type="comté" nuts="2">Oxfordshire</region><settlement type="city">Oxford</settlement></placeName><orgName type="university">Université d'Oxford</orgName></affiliation></author><author><name sortKey="Lyssenko, Valeriya" sort="Lyssenko, Valeriya" uniqKey="Lyssenko V" first="Valeriya" last="Lyssenko">Valeriya Lyssenko</name><affiliation wicri:level="1"><nlm:aff id="aff8"><addr-line>Department of Clinical Sciences, Diabetes and Endocrinology, Lund University Diabetes Centre, Lund University and Skåne University Hospital, Malmö, Sweden</addr-line></nlm:aff><country xml:lang="fr">Suède</country><wicri:regionArea>Department of Clinical Sciences, Diabetes and Endocrinology, Lund University Diabetes Centre, Lund University and Skåne University Hospital, Malmö</wicri:regionArea><wicri:noRegion>Malmö</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="aff45"><addr-line>Steno Diabetes Center, Gentofte, Denmark</addr-line></nlm:aff><country xml:lang="fr">Danemark</country><wicri:regionArea>Steno Diabetes Center, Gentofte</wicri:regionArea><wicri:noRegion>Gentofte</wicri:noRegion></affiliation></author><author><name sortKey="L R, Esa" sort="L R, Esa" uniqKey="L R E" first="Esa" last="L R">Esa L R</name><affiliation wicri:level="1"><nlm:aff id="aff46"><addr-line>Department of Mathematical Sciences, University of Oulu, Oulu, Finland</addr-line></nlm:aff><country xml:lang="fr">Finlande</country><wicri:regionArea>Department of Mathematical Sciences, University of Oulu, Oulu</wicri:regionArea><wicri:noRegion>Oulu</wicri:noRegion></affiliation></author><author><name sortKey="Rayner, Nigel W" sort="Rayner, Nigel W" uniqKey="Rayner N" first="Nigel W." last="Rayner">Nigel W. Rayner</name><affiliation wicri:level="4"><nlm:aff id="aff3"><addr-line>Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom</addr-line></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford</wicri:regionArea><placeName><settlement type="city">Oxford</settlement><region type="country">Angleterre</region><region type="comté" nuts="2">Oxfordshire</region><settlement type="city">Oxford</settlement></placeName><orgName type="university">Université d'Oxford</orgName></affiliation><affiliation wicri:level="4"><nlm:aff id="aff5"><addr-line>Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Oxford, United Kingdom</addr-line></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Oxford</wicri:regionArea><placeName><settlement type="city">Oxford</settlement><region type="country">Angleterre</region><region type="comté" nuts="2">Oxfordshire</region><settlement type="city">Oxford</settlement></placeName><orgName type="university">Université d'Oxford</orgName></affiliation><affiliation wicri:level="1"><nlm:aff id="aff47"><addr-line>Wellcome Trust Sanger Institute, Hinxton, United Kingdom</addr-line></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Wellcome Trust Sanger Institute, Hinxton</wicri:regionArea><wicri:noRegion>Hinxton</wicri:noRegion></affiliation></author><author><name sortKey="M Nnisto, Satu" sort="M Nnisto, Satu" uniqKey="M Nnisto S" first="Satu" last="M Nnistö">Satu M Nnistö</name><affiliation wicri:level="1"><nlm:aff id="aff24"><addr-line>Department of Chronic Disease Prevention, National Institute for Health and Welfare, Helsinki, Finland</addr-line></nlm:aff><country xml:lang="fr">Finlande</country><wicri:regionArea>Department of Chronic Disease Prevention, National Institute for Health and Welfare, Helsinki</wicri:regionArea><wicri:noRegion>Helsinki</wicri:noRegion></affiliation></author><author><name sortKey="Pouta, Anneli" sort="Pouta, Anneli" uniqKey="Pouta A" first="Anneli" last="Pouta">Anneli Pouta</name><affiliation wicri:level="1"><nlm:aff id="aff34"><addr-line>Department of Obstetrics and Gynaecology, Institute of Clinical Sciences, University of Oulu, Oulu, Finland</addr-line></nlm:aff><country xml:lang="fr">Finlande</country><wicri:regionArea>Department of Obstetrics and Gynaecology, Institute of Clinical Sciences, University of Oulu, Oulu</wicri:regionArea><wicri:noRegion>Oulu</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="aff48"><addr-line>Department of Children, Young People and Families, National Institute for Health and Welfare, Oulu, Finland</addr-line></nlm:aff><country xml:lang="fr">Finlande</country><wicri:regionArea>Department of Children, Young People and Families, National Institute for Health and Welfare, Oulu</wicri:regionArea><wicri:noRegion>Oulu</wicri:noRegion></affiliation></author><author><name sortKey="Rathmann, Wolfgang" sort="Rathmann, Wolfgang" uniqKey="Rathmann W" first="Wolfgang" last="Rathmann">Wolfgang Rathmann</name><affiliation wicri:level="3"><nlm:aff id="aff49"><addr-line>Institute of Biometrics and Epidemiology, German Diabetes Center, Düsseldorf University, Düsseldorf, Germany</addr-line></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Institute of Biometrics and Epidemiology, German Diabetes Center, Düsseldorf University, Düsseldorf</wicri:regionArea><placeName><region type="land" nuts="1">Rhénanie-du-Nord-Westphalie</region><region type="district" nuts="2">District de Düsseldorf</region><settlement type="city">Düsseldorf</settlement></placeName></affiliation></author><author><name sortKey="Rivadeneira, Fernando" sort="Rivadeneira, Fernando" uniqKey="Rivadeneira F" first="Fernando" last="Rivadeneira">Fernando Rivadeneira</name><affiliation wicri:level="3"><nlm:aff id="aff26"><addr-line>Netherlands Consortium for Healthy Ageing, Netherlands Genomics Initiative, Leiden, The Netherlands</addr-line></nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Netherlands Consortium for Healthy Ageing, Netherlands Genomics Initiative, Leiden</wicri:regionArea><placeName><settlement type="city">Leyde</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="aff50"><addr-line>Department of Internal Medicine, Erasmus Medical Center, Rotterdam, The Netherlands</addr-line></nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Internal Medicine, Erasmus Medical Center, Rotterdam</wicri:regionArea><placeName><settlement type="city">Rotterdam</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation></author><author><name sortKey="Ruokonen, Aimo" sort="Ruokonen, Aimo" uniqKey="Ruokonen A" first="Aimo" last="Ruokonen">Aimo Ruokonen</name><affiliation wicri:level="1"><nlm:aff id="aff51"><addr-line>Institute of Diagnostics, University of Oulu, Oulu, Finland</addr-line></nlm:aff><country xml:lang="fr">Finlande</country><wicri:regionArea>Institute of Diagnostics, University of Oulu, Oulu</wicri:regionArea><wicri:noRegion>Oulu</wicri:noRegion></affiliation></author><author><name sortKey="Savolainen, Markku J" sort="Savolainen, Markku J" uniqKey="Savolainen M" first="Markku J." last="Savolainen">Markku J. Savolainen</name><affiliation wicri:level="1"><nlm:aff id="aff27"><addr-line>Biocenter Oulu, University of Oulu, Oulu, Finland</addr-line></nlm:aff><country xml:lang="fr">Finlande</country><wicri:regionArea>Biocenter Oulu, University of Oulu, Oulu</wicri:regionArea><wicri:noRegion>Oulu</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="aff52"><addr-line>Department of Internal Medicine, Institute of Clinical Medicine, University of Oulu, Oulu, Finland</addr-line></nlm:aff><country xml:lang="fr">Finlande</country><wicri:regionArea>Department of Internal Medicine, Institute of Clinical Medicine, University of Oulu, Oulu</wicri:regionArea><wicri:noRegion>Oulu</wicri:noRegion></affiliation></author><author><name sortKey="Sijbrands, Eric J G" sort="Sijbrands, Eric J G" uniqKey="Sijbrands E" first="Eric J. G." last="Sijbrands">Eric J. G. Sijbrands</name><affiliation wicri:level="3"><nlm:aff id="aff50"><addr-line>Department of Internal Medicine, Erasmus Medical Center, Rotterdam, The Netherlands</addr-line></nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Internal Medicine, Erasmus Medical Center, Rotterdam</wicri:regionArea><placeName><settlement type="city">Rotterdam</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation></author><author><name sortKey="Small, Kerrin S" sort="Small, Kerrin S" uniqKey="Small K" first="Kerrin S." last="Small">Kerrin S. Small</name><affiliation wicri:level="1"><nlm:aff id="aff15"><addr-line>Department of Twin Research and Genetic Epidemiology, King's College London, United Kingdom</addr-line></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Twin Research and Genetic Epidemiology, King's College London</wicri:regionArea><wicri:noRegion>King's College London</wicri:noRegion></affiliation></author><author><name sortKey="Smit, Jan H" sort="Smit, Jan H" uniqKey="Smit J" first="Jan H." last="Smit">Jan H. Smit</name><affiliation wicri:level="3"><nlm:aff id="aff11"><addr-line>The EMGO Institute for Health and Care Research, Amsterdam, The Netherlands</addr-line></nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>The EMGO Institute for Health and Care Research, Amsterdam</wicri:regionArea><placeName><settlement type="city">Amsterdam</settlement><region nuts="2" type="province">Hollande-Septentrionale</region></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="aff53"><addr-line>Neuroscience Campus Amsterdam, Amsterdam, The Netherlands</addr-line></nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Neuroscience Campus Amsterdam, Amsterdam</wicri:regionArea><placeName><settlement type="city">Amsterdam</settlement><region nuts="2" type="province">Hollande-Septentrionale</region></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="aff54"><addr-line>Department of Psychiatry, VU University Medical Center, Amsterdam, The Netherlands</addr-line></nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Psychiatry, VU University Medical Center, Amsterdam</wicri:regionArea><placeName><settlement type="city">Amsterdam</settlement><region nuts="2" type="province">Hollande-Septentrionale</region></placeName></affiliation></author><author><name sortKey="Steinthorsdottir, Valgerdur" sort="Steinthorsdottir, Valgerdur" uniqKey="Steinthorsdottir V" first="Valgerdur" last="Steinthorsdottir">Valgerdur Steinthorsdottir</name><affiliation wicri:level="1"><nlm:aff id="aff7"><addr-line>deCODE Genetics, Reykjavik, Iceland</addr-line></nlm:aff><country xml:lang="fr">Islande</country><wicri:regionArea>deCODE Genetics, Reykjavik</wicri:regionArea><wicri:noRegion>Reykjavik</wicri:noRegion></affiliation></author><author><name sortKey="Syv Nen, Ann Christine" sort="Syv Nen, Ann Christine" uniqKey="Syv Nen A" first="Ann-Christine" last="Syv Nen">Ann-Christine Syv Nen</name><affiliation wicri:level="4"><nlm:aff id="aff55"><addr-line>Molecular Medicine and Science for Life Laboratory, Department of Medical Sciences, Uppsala University, Uppsala, Sweden</addr-line></nlm:aff><country xml:lang="fr">Suède</country><wicri:regionArea>Molecular Medicine and Science for Life Laboratory, Department of Medical Sciences, Uppsala University, Uppsala</wicri:regionArea><orgName type="university">Université d'Uppsala</orgName><placeName><settlement type="city">Uppsala</settlement><region nuts="1">Svealand</region><region nuts="1">East Middle Sweden</region></placeName></affiliation></author><author><name sortKey="Taanila, Anja" sort="Taanila, Anja" uniqKey="Taanila A" first="Anja" last="Taanila">Anja Taanila</name><affiliation wicri:level="1"><nlm:aff id="aff14"><addr-line>Institute of Health Sciences, University of Oulu, Oulu, Finland</addr-line></nlm:aff><country xml:lang="fr">Finlande</country><wicri:regionArea>Institute of Health Sciences, University of Oulu, Oulu</wicri:regionArea><wicri:noRegion>Oulu</wicri:noRegion></affiliation></author><author><name sortKey="Tobin, Martin D" sort="Tobin, Martin D" uniqKey="Tobin M" first="Martin D." last="Tobin">Martin D. Tobin</name><affiliation wicri:level="1"><nlm:aff id="aff56"><addr-line>Department of Health Sciences, University of Leicester, Leicester, United Kingdom</addr-line></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Health Sciences, University of Leicester, Leicester</wicri:regionArea><wicri:noRegion>Leicester</wicri:noRegion></affiliation></author><author><name sortKey="Uitterlinden, Andre G" sort="Uitterlinden, Andre G" uniqKey="Uitterlinden A" first="Andre G." last="Uitterlinden">Andre G. Uitterlinden</name><affiliation wicri:level="3"><nlm:aff id="aff50"><addr-line>Department of Internal Medicine, Erasmus Medical Center, Rotterdam, The Netherlands</addr-line></nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Internal Medicine, Erasmus Medical Center, Rotterdam</wicri:regionArea><placeName><settlement type="city">Rotterdam</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation></author><author><name sortKey="Willems, Sara M" sort="Willems, Sara M" uniqKey="Willems S" first="Sara M." last="Willems">Sara M. Willems</name><affiliation wicri:level="3"><nlm:aff id="aff23"><addr-line>Department of Genetic Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands</addr-line></nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Genetic Epidemiology, Erasmus Medical Center, Rotterdam</wicri:regionArea><placeName><settlement type="city">Rotterdam</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation></author><author><name sortKey="Willemsen, Gonneke" sort="Willemsen, Gonneke" uniqKey="Willemsen G" first="Gonneke" last="Willemsen">Gonneke Willemsen</name><affiliation wicri:level="3"><nlm:aff id="aff10"><addr-line>Department of Biological Psychology, VU University Amsterdam, Amsterdam, The Netherlands</addr-line></nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Biological Psychology, VU University Amsterdam, Amsterdam</wicri:regionArea><placeName><settlement type="city">Amsterdam</settlement><region nuts="2" type="province">Hollande-Septentrionale</region></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="aff11"><addr-line>The EMGO Institute for Health and Care Research, Amsterdam, The Netherlands</addr-line></nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>The EMGO Institute for Health and Care Research, Amsterdam</wicri:regionArea><placeName><settlement type="city">Amsterdam</settlement><region nuts="2" type="province">Hollande-Septentrionale</region></placeName></affiliation></author><author><name sortKey="Witteman, Jacqueline" sort="Witteman, Jacqueline" uniqKey="Witteman J" first="Jacqueline" last="Witteman">Jacqueline Witteman</name><affiliation wicri:level="3"><nlm:aff id="aff9"><addr-line>Department of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands</addr-line></nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Epidemiology, Erasmus Medical Center, Rotterdam</wicri:regionArea><placeName><settlement type="city">Rotterdam</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="aff26"><addr-line>Netherlands Consortium for Healthy Ageing, Netherlands Genomics Initiative, Leiden, The Netherlands</addr-line></nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Netherlands Consortium for Healthy Ageing, Netherlands Genomics Initiative, Leiden</wicri:regionArea><placeName><settlement type="city">Leyde</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation></author><author><name sortKey="Perola, Markus" sort="Perola, Markus" uniqKey="Perola M" first="Markus" last="Perola">Markus Perola</name><affiliation wicri:level="1"><nlm:aff id="aff4"><addr-line>Estonian Genome Center, University of Tartu, Tartu, Estonia</addr-line></nlm:aff><country xml:lang="fr">Estonie</country><wicri:regionArea>Estonian Genome Center, University of Tartu, Tartu</wicri:regionArea><wicri:noRegion>Tartu</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="aff24"><addr-line>Department of Chronic Disease Prevention, National Institute for Health and Welfare, Helsinki, Finland</addr-line></nlm:aff><country xml:lang="fr">Finlande</country><wicri:regionArea>Department of Chronic Disease Prevention, National Institute for Health and Welfare, Helsinki</wicri:regionArea><wicri:noRegion>Helsinki</wicri:noRegion></affiliation></author><author><name sortKey="Evans, Alun" sort="Evans, Alun" uniqKey="Evans A" first="Alun" last="Evans">Alun Evans</name><affiliation wicri:level="2"><nlm:aff id="aff57"><addr-line>Centre for Public Health, Queen's University of Belfast, Belfast, Northern Ireland</addr-line></nlm:aff><country>Royaume-Uni</country><placeName><region type="country">Irlande du Nord</region></placeName><wicri:cityArea>Centre for Public Health, Queen's University of Belfast, Belfast</wicri:cityArea></affiliation></author><author><name sortKey="Ferrieres, Jean" sort="Ferrieres, Jean" uniqKey="Ferrieres J" first="Jean" last="Ferrières">Jean Ferrières</name><affiliation wicri:level="3"><nlm:aff id="aff58"><addr-line>Department of Cardiology, Toulouse University School of Medicine, Rangueil Hospital, Toulouse, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Department of Cardiology, Toulouse University School of Medicine, Rangueil Hospital, Toulouse</wicri:regionArea><placeName><region type="region">Occitanie (région administrative)</region><region type="old region">Midi-Pyrénées</region><settlement type="city">Toulouse</settlement></placeName></affiliation></author><author><name sortKey="Virtamo, Jarmo" sort="Virtamo, Jarmo" uniqKey="Virtamo J" first="Jarmo" last="Virtamo">Jarmo Virtamo</name><affiliation wicri:level="1"><nlm:aff id="aff24"><addr-line>Department of Chronic Disease Prevention, National Institute for Health and Welfare, Helsinki, Finland</addr-line></nlm:aff><country xml:lang="fr">Finlande</country><wicri:regionArea>Department of Chronic Disease Prevention, National Institute for Health and Welfare, Helsinki</wicri:regionArea><wicri:noRegion>Helsinki</wicri:noRegion></affiliation></author><author><name sortKey="Kee, Frank" sort="Kee, Frank" uniqKey="Kee F" first="Frank" last="Kee">Frank Kee</name><affiliation wicri:level="2"><nlm:aff id="aff59"><addr-line>Centre of Excellence for Public Health Northern Ireland, Queen's University of Belfast, Belfast, Northern Ireland</addr-line></nlm:aff><country>Royaume-Uni</country><placeName><region type="country">Irlande du Nord</region></placeName><wicri:cityArea>Centre of Excellence for Public Health Northern Ireland, Queen's University of Belfast, Belfast</wicri:cityArea></affiliation></author><author><name sortKey="Tregouet, David Alexandre" sort="Tregouet, David Alexandre" uniqKey="Tregouet D" first="David-Alexandre" last="Tregouet">David-Alexandre Tregouet</name><affiliation wicri:level="3"><nlm:aff id="aff60"><addr-line>Institute of Cardiometabolism and Nutrition, INSERM UMR S937, Pierre and Marie Curie University, Paris, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Institute of Cardiometabolism and Nutrition, INSERM UMR S937, Pierre and Marie Curie University, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Arveiler, Dominique" sort="Arveiler, Dominique" uniqKey="Arveiler D" first="Dominique" last="Arveiler">Dominique Arveiler</name><affiliation wicri:level="3"><nlm:aff id="aff61"><addr-line>Department of Epidemiology and Public Health, University of Strasbourg, Strasbourg, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Department of Epidemiology and Public Health, University of Strasbourg, Strasbourg</wicri:regionArea><placeName><region type="region">Grand Est</region><region type="old region">Alsace (région administrative)</region><settlement type="city">Strasbourg</settlement></placeName></affiliation></author><author><name sortKey="Amouyel, Philippe" sort="Amouyel, Philippe" uniqKey="Amouyel P" first="Philippe" last="Amouyel">Philippe Amouyel</name><affiliation wicri:level="3"><nlm:aff id="aff62"><addr-line>Institut Pasteur de Lille, INSERM U744, Université Lille Nord de France, Lille, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Institut Pasteur de Lille, INSERM U744, Université Lille Nord de France, Lille</wicri:regionArea><placeName><region type="region">Hauts-de-France</region><region type="old region">Nord-Pas-de-Calais</region><settlement type="city">Lille</settlement></placeName></affiliation></author><author><name sortKey="Ferrario, Marco M" sort="Ferrario, Marco M" uniqKey="Ferrario M" first="Marco M." last="Ferrario">Marco M. Ferrario</name><affiliation wicri:level="1"><nlm:aff id="aff63"><addr-line>Epidemiology and Preventive Medicine Research Centre, Department of Clinical and Experimental Medicine, University of Insubria, Varese, Italy</addr-line></nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Epidemiology and Preventive Medicine Research Centre, Department of Clinical and Experimental Medicine, University of Insubria, Varese</wicri:regionArea><wicri:noRegion>Varese</wicri:noRegion></affiliation></author><author><name sortKey="Brambilla, Paolo" sort="Brambilla, Paolo" uniqKey="Brambilla P" first="Paolo" last="Brambilla">Paolo Brambilla</name><affiliation wicri:level="1"><nlm:aff id="aff64"><addr-line>Department of Experimental Medicine, University of Milano-Bicocca, Monza, Italy</addr-line></nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Experimental Medicine, University of Milano-Bicocca, Monza</wicri:regionArea><wicri:noRegion>Monza</wicri:noRegion></affiliation></author><author><name sortKey="Hall, Alistair S" sort="Hall, Alistair S" uniqKey="Hall A" first="Alistair S." last="Hall">Alistair S. Hall</name><affiliation wicri:level="4"><nlm:aff id="aff30"><addr-line>Division of Epidemiology, Leeds Institute of Genetics, Health and Therapeutics, School of Medicine, University of Leeds, Leeds, United Kingdom</addr-line></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Division of Epidemiology, Leeds Institute of Genetics, Health and Therapeutics, School of Medicine, University of Leeds, Leeds</wicri:regionArea><orgName type="university">Université de Leeds</orgName><placeName><settlement type="city">Leeds</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Yorkshire-et-Humber</region></placeName></affiliation></author><author><name sortKey="Heath, Andrew C" sort="Heath, Andrew C" uniqKey="Heath A" first="Andrew C." last="Heath">Andrew C. Heath</name><affiliation wicri:level="4"><nlm:aff id="aff65"><addr-line>Washington University School of Medicine, St Louis, Missouri, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Washington University School of Medicine, St Louis, Missouri</wicri:regionArea><placeName><region type="state">Missouri (État)</region><settlement type="city">Saint-Louis (Missouri)</settlement></placeName><orgName type="university">École de médecine (Université Washington de Saint-Louis)</orgName></affiliation></author><author><name sortKey="Madden, Pamela A F" sort="Madden, Pamela A F" uniqKey="Madden P" first="Pamela A. F." last="Madden">Pamela A. F. Madden</name><affiliation wicri:level="4"><nlm:aff id="aff65"><addr-line>Washington University School of Medicine, St Louis, Missouri, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Washington University School of Medicine, St Louis, Missouri</wicri:regionArea><placeName><region type="state">Missouri (État)</region><settlement type="city">Saint-Louis (Missouri)</settlement></placeName><orgName type="university">École de médecine (Université Washington de Saint-Louis)</orgName></affiliation></author><author><name sortKey="Martin, Nicholas G" sort="Martin, Nicholas G" uniqKey="Martin N" first="Nicholas G." last="Martin">Nicholas G. Martin</name><affiliation wicri:level="1"><nlm:aff id="aff17"><addr-line>Queensland Institute of Medical Research, Herston, Australia</addr-line></nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Queensland Institute of Medical Research, Herston</wicri:regionArea><wicri:noRegion>Herston</wicri:noRegion></affiliation></author><author><name sortKey="Montgomery, Grant W" sort="Montgomery, Grant W" uniqKey="Montgomery G" first="Grant W." last="Montgomery">Grant W. Montgomery</name><affiliation wicri:level="1"><nlm:aff id="aff17"><addr-line>Queensland Institute of Medical Research, Herston, Australia</addr-line></nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Queensland Institute of Medical Research, Herston</wicri:regionArea><wicri:noRegion>Herston</wicri:noRegion></affiliation></author><author><name sortKey="Whitfield, John B" sort="Whitfield, John B" uniqKey="Whitfield J" first="John B." last="Whitfield">John B. Whitfield</name><affiliation wicri:level="1"><nlm:aff id="aff17"><addr-line>Queensland Institute of Medical Research, Herston, Australia</addr-line></nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Queensland Institute of Medical Research, Herston</wicri:regionArea><wicri:noRegion>Herston</wicri:noRegion></affiliation></author><author><name sortKey="Jula, Antti" sort="Jula, Antti" uniqKey="Jula A" first="Antti" last="Jula">Antti Jula</name><affiliation wicri:level="3"><nlm:aff id="aff66"><addr-line>Population Studies Unit, Department of Chronic Disease Prevention, National Institute for Health and Welfare, Turku, Finland</addr-line></nlm:aff><country xml:lang="fr">Finlande</country><wicri:regionArea>Population Studies Unit, Department of Chronic Disease Prevention, National Institute for Health and Welfare, Turku</wicri:regionArea><placeName><settlement type="city">Turku</settlement><region type="région" nuts="2">Finlande occidentale</region></placeName></affiliation></author><author><name sortKey="Knekt, Paul" sort="Knekt, Paul" uniqKey="Knekt P" first="Paul" last="Knekt">Paul Knekt</name><affiliation wicri:level="1"><nlm:aff id="aff67"><addr-line>Department of Health, Functional Capacity and Welfare, National Institute for Health and Welfare, Helsinki, Finland</addr-line></nlm:aff><country xml:lang="fr">Finlande</country><wicri:regionArea>Department of Health, Functional Capacity and Welfare, National Institute for Health and Welfare, Helsinki</wicri:regionArea><wicri:noRegion>Helsinki</wicri:noRegion></affiliation></author><author><name sortKey="Oostra, Ben" sort="Oostra, Ben" uniqKey="Oostra B" first="Ben" last="Oostra">Ben Oostra</name><affiliation wicri:level="3"><nlm:aff id="aff68"><addr-line>Department of Clinical Genetics, Erasmus Medical Center, Rotterdam, The Netherlands</addr-line></nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Clinical Genetics, Erasmus Medical Center, Rotterdam</wicri:regionArea><placeName><settlement type="city">Rotterdam</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation></author><author><name sortKey="Van Duijn, Cornelia M" sort="Van Duijn, Cornelia M" uniqKey="Van Duijn C" first="Cornelia M." last="Van Duijn">Cornelia M. Van Duijn</name><affiliation wicri:level="3"><nlm:aff id="aff23"><addr-line>Department of Genetic Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands</addr-line></nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Genetic Epidemiology, Erasmus Medical Center, Rotterdam</wicri:regionArea><placeName><settlement type="city">Rotterdam</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="aff69"><addr-line>Netherlands Genomic Initiative, Leiden, The Netherlands</addr-line></nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Netherlands Genomic Initiative, Leiden</wicri:regionArea><placeName><settlement type="city">Leyde</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="aff70"><addr-line>Centre for Medical Systems Biology, Leiden, The Netherlands</addr-line></nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Centre for Medical Systems Biology, Leiden</wicri:regionArea><placeName><settlement type="city">Leyde</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation></author><author><name sortKey="Penninx, Brenda W J H" sort="Penninx, Brenda W J H" uniqKey="Penninx B" first="Brenda W. J. H." last="Penninx">Brenda W. J. H. Penninx</name><affiliation wicri:level="3"><nlm:aff id="aff11"><addr-line>The EMGO Institute for Health and Care Research, Amsterdam, The Netherlands</addr-line></nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>The EMGO Institute for Health and Care Research, Amsterdam</wicri:regionArea><placeName><settlement type="city">Amsterdam</settlement><region nuts="2" type="province">Hollande-Septentrionale</region></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="aff54"><addr-line>Department of Psychiatry, VU University Medical Center, Amsterdam, The Netherlands</addr-line></nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Psychiatry, VU University Medical Center, Amsterdam</wicri:regionArea><placeName><settlement type="city">Amsterdam</settlement><region nuts="2" type="province">Hollande-Septentrionale</region></placeName></affiliation></author><author><name sortKey="Davey Smith, George" sort="Davey Smith, George" uniqKey="Davey Smith G" first="George" last="Davey Smith">George Davey Smith</name><affiliation wicri:level="1"><nlm:aff id="aff71"><addr-line>MRC Centre for Integrative Epidemiology Unit, University of Bristol, Bristol, United Kingdom</addr-line></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>MRC Centre for Integrative Epidemiology Unit, University of Bristol, Bristol</wicri:regionArea><wicri:noRegion>Bristol</wicri:noRegion></affiliation></author><author><name sortKey="Kaprio, Jaakko" sort="Kaprio, Jaakko" uniqKey="Kaprio J" first="Jaakko" last="Kaprio">Jaakko Kaprio</name><affiliation wicri:level="4"><nlm:aff id="aff6"><addr-line>Institute for Molecular Medicine Finland, University of Helsinki, Helsinki, Finland</addr-line></nlm:aff><country xml:lang="fr">Finlande</country><wicri:regionArea>Institute for Molecular Medicine Finland, University of Helsinki, Helsinki</wicri:regionArea><orgName type="university">Université d'Helsinki</orgName><placeName><settlement type="city">Helsinki</settlement><region type="région" nuts="2">Uusimaa</region></placeName></affiliation><affiliation wicri:level="4"><nlm:aff id="aff35"><addr-line>Department of Public Health, Hjelt Institute, University of Helsinki, Helsinki, Finland</addr-line></nlm:aff><country xml:lang="fr">Finlande</country><wicri:regionArea>Department of Public Health, Hjelt Institute, University of Helsinki, Helsinki</wicri:regionArea><orgName type="university">Université d'Helsinki</orgName><placeName><settlement type="city">Helsinki</settlement><region type="région" nuts="2">Uusimaa</region></placeName></affiliation><affiliation wicri:level="1"><nlm:aff id="aff72"><addr-line>Department of Mental Health and Substance Abuse Services, National Institute for Health and Welfare, Helsinki, Finland</addr-line></nlm:aff><country xml:lang="fr">Finlande</country><wicri:regionArea>Department of Mental Health and Substance Abuse Services, National Institute for Health and Welfare, Helsinki</wicri:regionArea><wicri:noRegion>Helsinki</wicri:noRegion></affiliation></author><author><name sortKey="Samani, Nilesh J" sort="Samani, Nilesh J" uniqKey="Samani N" first="Nilesh J." last="Samani">Nilesh J. Samani</name><affiliation wicri:level="1"><nlm:aff id="aff19"><addr-line>Department of Cardiovascular Sciences, University of Leicester, Leicester, United Kingdom</addr-line></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Cardiovascular Sciences, University of Leicester, Leicester</wicri:regionArea><wicri:noRegion>Leicester</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="aff20"><addr-line>National Institute for Health Research, Leicester Cardiovascular Biomedical Research Unit, Glenfield Hospital, Leicester, United Kingdom</addr-line></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>National Institute for Health Research, Leicester Cardiovascular Biomedical Research Unit, Glenfield Hospital, Leicester</wicri:regionArea><wicri:noRegion>Leicester</wicri:noRegion></affiliation></author><author><name sortKey="Gieger, Christian" sort="Gieger, Christian" uniqKey="Gieger C" first="Christian" last="Gieger">Christian Gieger</name><affiliation wicri:level="1"><nlm:aff id="aff12"><addr-line>Institute of Genetic Epidemiology, Helmholtz Zentrum München—German Research Center for Environmental Health, Neuherberg, Germany</addr-line></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Institute of Genetic Epidemiology, Helmholtz Zentrum München—German Research Center for Environmental Health, Neuherberg</wicri:regionArea><wicri:noRegion>Neuherberg</wicri:noRegion><wicri:noRegion>Neuherberg</wicri:noRegion><wicri:noRegion>Neuherberg</wicri:noRegion></affiliation></author><author><name sortKey="Peters, Annette" sort="Peters, Annette" uniqKey="Peters A" first="Annette" last="Peters">Annette Peters</name><affiliation wicri:level="1"><nlm:aff id="aff32"><addr-line>Institute of Epidemiology II, Helmholtz Zentrum München—German Research Center for Environmental Health, Neuherberg, Germany</addr-line></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Institute of Epidemiology II, Helmholtz Zentrum München—German Research Center for Environmental Health, Neuherberg</wicri:regionArea><wicri:noRegion>Neuherberg</wicri:noRegion><wicri:noRegion>Neuherberg</wicri:noRegion><wicri:noRegion>Neuherberg</wicri:noRegion></affiliation><affiliation wicri:level="3"><nlm:aff id="aff73"><addr-line>Munich Heart Alliance, Munich, Germany</addr-line></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Munich Heart Alliance, Munich</wicri:regionArea><placeName><region type="land" nuts="1">Bavière</region><region type="district" nuts="2">District de Haute-Bavière</region><settlement type="city">Munich</settlement></placeName></affiliation></author><author><name sortKey="Wichmann, H Erich" sort="Wichmann, H Erich" uniqKey="Wichmann H" first="H.-Erich" last="Wichmann">H.-Erich Wichmann</name><affiliation wicri:level="1"><nlm:aff id="aff31"><addr-line>Institute of Epidemiology I, Helmholtz Zentrum München—German Research Center for Environmental Health, Neuherberg, Germany</addr-line></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Institute of Epidemiology I, Helmholtz Zentrum München—German Research Center for Environmental Health, Neuherberg</wicri:regionArea><wicri:noRegion>Neuherberg</wicri:noRegion><wicri:noRegion>Neuherberg</wicri:noRegion><wicri:noRegion>Neuherberg</wicri:noRegion></affiliation><affiliation wicri:level="3"><nlm:aff id="aff74"><addr-line>Institute of Medical Informatics, Biometry and Epidemiology, Chair of Epidemiology, Ludwig-Maximilians-Universität, Munich, Germany</addr-line></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Institute of Medical Informatics, Biometry and Epidemiology, Chair of Epidemiology, Ludwig-Maximilians-Universität, Munich</wicri:regionArea><placeName><region type="land" nuts="1">Bavière</region><region type="district" nuts="2">District de Haute-Bavière</region><settlement type="city">Munich</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="aff75"><addr-line>Klinikum Grosshadern, Munich, Germany</addr-line></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Klinikum Grosshadern, Munich</wicri:regionArea><placeName><region type="land" nuts="1">Bavière</region><region type="district" nuts="2">District de Haute-Bavière</region><settlement type="city">Munich</settlement></placeName></affiliation></author><author><name sortKey="Boomsma, Dorret I" sort="Boomsma, Dorret I" uniqKey="Boomsma D" first="Dorret I." last="Boomsma">Dorret I. Boomsma</name><affiliation wicri:level="3"><nlm:aff id="aff10"><addr-line>Department of Biological Psychology, VU University Amsterdam, Amsterdam, The Netherlands</addr-line></nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Biological Psychology, VU University Amsterdam, Amsterdam</wicri:regionArea><placeName><settlement type="city">Amsterdam</settlement><region nuts="2" type="province">Hollande-Septentrionale</region></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="aff11"><addr-line>The EMGO Institute for Health and Care Research, Amsterdam, The Netherlands</addr-line></nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>The EMGO Institute for Health and Care Research, Amsterdam</wicri:regionArea><placeName><settlement type="city">Amsterdam</settlement><region nuts="2" type="province">Hollande-Septentrionale</region></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="aff53"><addr-line>Neuroscience Campus Amsterdam, Amsterdam, The Netherlands</addr-line></nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Neuroscience Campus Amsterdam, Amsterdam</wicri:regionArea><placeName><settlement type="city">Amsterdam</settlement><region nuts="2" type="province">Hollande-Septentrionale</region></placeName></affiliation></author><author><name sortKey="De Geus, Eco J C" sort="De Geus, Eco J C" uniqKey="De Geus E" first="Eco J. C." last="De Geus">Eco J. C. De Geus</name><affiliation wicri:level="3"><nlm:aff id="aff10"><addr-line>Department of Biological Psychology, VU University Amsterdam, Amsterdam, The Netherlands</addr-line></nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Biological Psychology, VU University Amsterdam, Amsterdam</wicri:regionArea><placeName><settlement type="city">Amsterdam</settlement><region nuts="2" type="province">Hollande-Septentrionale</region></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="aff11"><addr-line>The EMGO Institute for Health and Care Research, Amsterdam, The Netherlands</addr-line></nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>The EMGO Institute for Health and Care Research, Amsterdam</wicri:regionArea><placeName><settlement type="city">Amsterdam</settlement><region nuts="2" type="province">Hollande-Septentrionale</region></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="aff53"><addr-line>Neuroscience Campus Amsterdam, Amsterdam, The Netherlands</addr-line></nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Neuroscience Campus Amsterdam, Amsterdam</wicri:regionArea><placeName><settlement type="city">Amsterdam</settlement><region nuts="2" type="province">Hollande-Septentrionale</region></placeName></affiliation></author><author><name sortKey="Tuomi, Tiinamaija" sort="Tuomi, Tiinamaija" uniqKey="Tuomi T" first="Tiinamaija" last="Tuomi">Tiinamaija Tuomi</name><affiliation wicri:level="1"><nlm:aff id="aff42"><addr-line>Folkhälsan Research Centre, Helsinki, Finland</addr-line></nlm:aff><country xml:lang="fr">Finlande</country><wicri:regionArea>Folkhälsan Research Centre, Helsinki</wicri:regionArea><wicri:noRegion>Helsinki</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="aff76"><addr-line>Department of Medicine, Helsinki University Central Hospital, Helsinki, Finland</addr-line></nlm:aff><country xml:lang="fr">Finlande</country><wicri:regionArea>Department of Medicine, Helsinki University Central Hospital, Helsinki</wicri:regionArea><wicri:noRegion>Helsinki</wicri:noRegion></affiliation></author><author><name sortKey="Power, Chris" sort="Power, Chris" uniqKey="Power C" first="Chris" last="Power">Chris Power</name><affiliation wicri:level="3"><nlm:aff id="aff38"><addr-line>Centre for Paediatric Epidemiology and Biostatistics and Medical Research Council Centre for the Epidemiology of Child Health, University College London Institute of Child Health, London, United Kingdom</addr-line></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Centre for Paediatric Epidemiology and Biostatistics and Medical Research Council Centre for the Epidemiology of Child Health, University College London Institute of Child Health, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Hammond, Christopher J" sort="Hammond, Christopher J" uniqKey="Hammond C" first="Christopher J." last="Hammond">Christopher J. Hammond</name><affiliation wicri:level="1"><nlm:aff id="aff15"><addr-line>Department of Twin Research and Genetic Epidemiology, King's College London, United Kingdom</addr-line></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Twin Research and Genetic Epidemiology, King's College London</wicri:regionArea><wicri:noRegion>King's College London</wicri:noRegion></affiliation></author><author><name sortKey="Spector, Tim D" sort="Spector, Tim D" uniqKey="Spector T" first="Tim D." last="Spector">Tim D. Spector</name><affiliation wicri:level="1"><nlm:aff id="aff15"><addr-line>Department of Twin Research and Genetic Epidemiology, King's College London, United Kingdom</addr-line></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Twin Research and Genetic Epidemiology, King's College London</wicri:regionArea><wicri:noRegion>King's College London</wicri:noRegion></affiliation></author><author><name sortKey="Lind, Lars" sort="Lind, Lars" uniqKey="Lind L" first="Lars" last="Lind">Lars Lind</name><affiliation wicri:level="4"><nlm:aff id="aff77"><addr-line>Department of Medical Sciences, Uppsala University, Uppsala, Sweden</addr-line></nlm:aff><country xml:lang="fr">Suède</country><wicri:regionArea>Department of Medical Sciences, Uppsala University, Uppsala</wicri:regionArea><orgName type="university">Université d'Uppsala</orgName><placeName><settlement type="city">Uppsala</settlement><region nuts="1">Svealand</region><region nuts="1">East Middle Sweden</region></placeName></affiliation></author><author><name sortKey="Orho Melander, Marju" sort="Orho Melander, Marju" uniqKey="Orho Melander M" first="Marju" last="Orho-Melander">Marju Orho-Melander</name><affiliation wicri:level="1"><nlm:aff id="aff8"><addr-line>Department of Clinical Sciences, Diabetes and Endocrinology, Lund University Diabetes Centre, Lund University and Skåne University Hospital, Malmö, Sweden</addr-line></nlm:aff><country xml:lang="fr">Suède</country><wicri:regionArea>Department of Clinical Sciences, Diabetes and Endocrinology, Lund University Diabetes Centre, Lund University and Skåne University Hospital, Malmö</wicri:regionArea><wicri:noRegion>Malmö</wicri:noRegion></affiliation></author><author><name sortKey="Palmer, Colin Neil Alexander" sort="Palmer, Colin Neil Alexander" uniqKey="Palmer C" first="Colin Neil Alexander" last="Palmer">Colin Neil Alexander Palmer</name><affiliation wicri:level="1"><nlm:aff id="aff13"><addr-line>Medical Research Institute, Ninewells Hospital and Medical School, University of Dundee, Dundee, United Kingdom</addr-line></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Medical Research Institute, Ninewells Hospital and Medical School, University of Dundee, Dundee</wicri:regionArea><wicri:noRegion>Dundee</wicri:noRegion></affiliation></author><author><name sortKey="Morris, Andrew D" sort="Morris, Andrew D" uniqKey="Morris A" first="Andrew D." last="Morris">Andrew D. Morris</name><affiliation wicri:level="1"><nlm:aff id="aff13"><addr-line>Medical Research Institute, Ninewells Hospital and Medical School, University of Dundee, Dundee, United Kingdom</addr-line></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Medical Research Institute, Ninewells Hospital and Medical School, University of Dundee, Dundee</wicri:regionArea><wicri:noRegion>Dundee</wicri:noRegion></affiliation></author><author><name sortKey="Groop, Leif" sort="Groop, Leif" uniqKey="Groop L" first="Leif" last="Groop">Leif Groop</name><affiliation wicri:level="4"><nlm:aff id="aff6"><addr-line>Institute for Molecular Medicine Finland, University of Helsinki, Helsinki, Finland</addr-line></nlm:aff><country xml:lang="fr">Finlande</country><wicri:regionArea>Institute for Molecular Medicine Finland, University of Helsinki, Helsinki</wicri:regionArea><orgName type="university">Université d'Helsinki</orgName><placeName><settlement type="city">Helsinki</settlement><region type="région" nuts="2">Uusimaa</region></placeName></affiliation><affiliation wicri:level="1"><nlm:aff id="aff8"><addr-line>Department of Clinical Sciences, Diabetes and Endocrinology, Lund University Diabetes Centre, Lund University and Skåne University Hospital, Malmö, Sweden</addr-line></nlm:aff><country xml:lang="fr">Suède</country><wicri:regionArea>Department of Clinical Sciences, Diabetes and Endocrinology, Lund University Diabetes Centre, Lund University and Skåne University Hospital, Malmö</wicri:regionArea><wicri:noRegion>Malmö</wicri:noRegion></affiliation></author><author><name sortKey="J Rvelin, Marjo Riitta" sort="J Rvelin, Marjo Riitta" uniqKey="J Rvelin M" first="Marjo-Riitta" last="J Rvelin">Marjo-Riitta J Rvelin</name><affiliation wicri:level="1"><nlm:aff id="aff14"><addr-line>Institute of Health Sciences, University of Oulu, Oulu, Finland</addr-line></nlm:aff><country xml:lang="fr">Finlande</country><wicri:regionArea>Institute of Health Sciences, University of Oulu, Oulu</wicri:regionArea><wicri:noRegion>Oulu</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="aff27"><addr-line>Biocenter Oulu, University of Oulu, Oulu, Finland</addr-line></nlm:aff><country xml:lang="fr">Finlande</country><wicri:regionArea>Biocenter Oulu, University of Oulu, Oulu</wicri:regionArea><wicri:noRegion>Oulu</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="aff48"><addr-line>Department of Children, Young People and Families, National Institute for Health and Welfare, Oulu, Finland</addr-line></nlm:aff><country xml:lang="fr">Finlande</country><wicri:regionArea>Department of Children, Young People and Families, National Institute for Health and Welfare, Oulu</wicri:regionArea><wicri:noRegion>Oulu</wicri:noRegion></affiliation><affiliation wicri:level="3"><nlm:aff id="aff78"><addr-line>Department of Epidemiology and Biostatistics, Imperial College London, London, United Kingdom</addr-line></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Epidemiology and Biostatistics, Imperial College London, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Salomaa, Veikko" sort="Salomaa, Veikko" uniqKey="Salomaa V" first="Veikko" last="Salomaa">Veikko Salomaa</name><affiliation wicri:level="1"><nlm:aff id="aff24"><addr-line>Department of Chronic Disease Prevention, National Institute for Health and Welfare, Helsinki, Finland</addr-line></nlm:aff><country xml:lang="fr">Finlande</country><wicri:regionArea>Department of Chronic Disease Prevention, National Institute for Health and Welfare, Helsinki</wicri:regionArea><wicri:noRegion>Helsinki</wicri:noRegion></affiliation></author><author><name sortKey="Vartiainen, Erkki" sort="Vartiainen, Erkki" uniqKey="Vartiainen E" first="Erkki" last="Vartiainen">Erkki Vartiainen</name><affiliation wicri:level="1"><nlm:aff id="aff79"><addr-line>Division of Welfare and Health Promotion, National Institute for Health and Welfare, Helsinki, Finland</addr-line></nlm:aff><country xml:lang="fr">Finlande</country><wicri:regionArea>Division of Welfare and Health Promotion, National Institute for Health and Welfare, Helsinki</wicri:regionArea><wicri:noRegion>Helsinki</wicri:noRegion></affiliation></author><author><name sortKey="Hofman, Albert" sort="Hofman, Albert" uniqKey="Hofman A" first="Albert" last="Hofman">Albert Hofman</name><affiliation wicri:level="3"><nlm:aff id="aff9"><addr-line>Department of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands</addr-line></nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Epidemiology, Erasmus Medical Center, Rotterdam</wicri:regionArea><placeName><settlement type="city">Rotterdam</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="aff26"><addr-line>Netherlands Consortium for Healthy Ageing, Netherlands Genomics Initiative, Leiden, The Netherlands</addr-line></nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Netherlands Consortium for Healthy Ageing, Netherlands Genomics Initiative, Leiden</wicri:regionArea><placeName><settlement type="city">Leyde</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation></author><author><name sortKey="Ripatti, Samuli" sort="Ripatti, Samuli" uniqKey="Ripatti S" first="Samuli" last="Ripatti">Samuli Ripatti</name><affiliation wicri:level="4"><nlm:aff id="aff6"><addr-line>Institute for Molecular Medicine Finland, University of Helsinki, Helsinki, Finland</addr-line></nlm:aff><country xml:lang="fr">Finlande</country><wicri:regionArea>Institute for Molecular Medicine Finland, University of Helsinki, Helsinki</wicri:regionArea><orgName type="university">Université d'Helsinki</orgName><placeName><settlement type="city">Helsinki</settlement><region type="région" nuts="2">Uusimaa</region></placeName></affiliation><affiliation wicri:level="1"><nlm:aff id="aff24"><addr-line>Department of Chronic Disease Prevention, National Institute for Health and Welfare, Helsinki, Finland</addr-line></nlm:aff><country xml:lang="fr">Finlande</country><wicri:regionArea>Department of Chronic Disease Prevention, National Institute for Health and Welfare, Helsinki</wicri:regionArea><wicri:noRegion>Helsinki</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="aff47"><addr-line>Wellcome Trust Sanger Institute, Hinxton, United Kingdom</addr-line></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Wellcome Trust Sanger Institute, Hinxton</wicri:regionArea><wicri:noRegion>Hinxton</wicri:noRegion></affiliation></author><author><name sortKey="Metspalu, Andres" sort="Metspalu, Andres" uniqKey="Metspalu A" first="Andres" last="Metspalu">Andres Metspalu</name><affiliation wicri:level="1"><nlm:aff id="aff4"><addr-line>Estonian Genome Center, University of Tartu, Tartu, Estonia</addr-line></nlm:aff><country xml:lang="fr">Estonie</country><wicri:regionArea>Estonian Genome Center, University of Tartu, Tartu</wicri:regionArea><wicri:noRegion>Tartu</wicri:noRegion></affiliation></author><author><name sortKey="Thorsteinsdottir, Unnur" sort="Thorsteinsdottir, Unnur" uniqKey="Thorsteinsdottir U" first="Unnur" last="Thorsteinsdottir">Unnur Thorsteinsdottir</name><affiliation wicri:level="1"><nlm:aff id="aff7"><addr-line>deCODE Genetics, Reykjavik, Iceland</addr-line></nlm:aff><country xml:lang="fr">Islande</country><wicri:regionArea>deCODE Genetics, Reykjavik</wicri:regionArea><wicri:noRegion>Reykjavik</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="aff80"><addr-line>Faculty of Medicine, University of Iceland, Reykjavík, Iceland</addr-line></nlm:aff><country xml:lang="fr">Islande</country><wicri:regionArea>Faculty of Medicine, University of Iceland, Reykjavík</wicri:regionArea><wicri:noRegion>Reykjavík</wicri:noRegion></affiliation></author><author><name sortKey="Stefansson, Kari" sort="Stefansson, Kari" uniqKey="Stefansson K" first="Kari" last="Stefansson">Kari Stefansson</name><affiliation wicri:level="1"><nlm:aff id="aff7"><addr-line>deCODE Genetics, Reykjavik, Iceland</addr-line></nlm:aff><country xml:lang="fr">Islande</country><wicri:regionArea>deCODE Genetics, Reykjavik</wicri:regionArea><wicri:noRegion>Reykjavik</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="aff80"><addr-line>Faculty of Medicine, University of Iceland, Reykjavík, Iceland</addr-line></nlm:aff><country xml:lang="fr">Islande</country><wicri:regionArea>Faculty of Medicine, University of Iceland, Reykjavík</wicri:regionArea><wicri:noRegion>Reykjavík</wicri:noRegion></affiliation></author><author><name sortKey="Pedersen, Nancy L" sort="Pedersen, Nancy L" uniqKey="Pedersen N" first="Nancy L." last="Pedersen">Nancy L. Pedersen</name><affiliation wicri:level="3"><nlm:aff id="aff2"><addr-line>Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden</addr-line></nlm:aff><country xml:lang="fr">Suède</country><wicri:regionArea>Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm</wicri:regionArea><placeName><settlement type="city">Stockholm</settlement><region nuts="2">Svealand</region></placeName></affiliation></author><author><name sortKey="Mccarthy, Mark I" sort="Mccarthy, Mark I" uniqKey="Mccarthy M" first="Mark I." last="Mccarthy">Mark I. Mccarthy</name><affiliation wicri:level="4"><nlm:aff id="aff3"><addr-line>Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom</addr-line></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford</wicri:regionArea><placeName><settlement type="city">Oxford</settlement><region type="country">Angleterre</region><region type="comté" nuts="2">Oxfordshire</region><settlement type="city">Oxford</settlement></placeName><orgName type="university">Université d'Oxford</orgName></affiliation><affiliation wicri:level="4"><nlm:aff id="aff5"><addr-line>Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Oxford, United Kingdom</addr-line></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Oxford</wicri:regionArea><placeName><settlement type="city">Oxford</settlement><region type="country">Angleterre</region><region type="comté" nuts="2">Oxfordshire</region><settlement type="city">Oxford</settlement></placeName><orgName type="university">Université d'Oxford</orgName></affiliation><affiliation wicri:level="3"><nlm:aff id="aff81"><addr-line>Oxford National Institute for Health Research Biomedical Research Centre, Churchill Hospital, Oxford, United Kingdom</addr-line></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Oxford National Institute for Health Research Biomedical Research Centre, Churchill Hospital, Oxford</wicri:regionArea><placeName><settlement type="city">Oxford</settlement><region type="country">Angleterre</region><region type="comté" nuts="2">Oxfordshire</region></placeName></affiliation></author><author><name sortKey="Ingelsson, Erik" sort="Ingelsson, Erik" uniqKey="Ingelsson E" first="Erik" last="Ingelsson">Erik Ingelsson</name><affiliation wicri:level="4"><nlm:aff id="aff1"><addr-line>Molecular Epidemiology and Science for Life Laboratory, Department of Medical Sciences, Uppsala University, Uppsala, Sweden</addr-line></nlm:aff><country xml:lang="fr">Suède</country><wicri:regionArea>Molecular Epidemiology and Science for Life Laboratory, Department of Medical Sciences, Uppsala University, Uppsala</wicri:regionArea><orgName type="university">Université d'Uppsala</orgName><placeName><settlement type="city">Uppsala</settlement><region nuts="1">Svealand</region><region nuts="1">East Middle Sweden</region></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="aff2"><addr-line>Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden</addr-line></nlm:aff><country xml:lang="fr">Suède</country><wicri:regionArea>Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm</wicri:regionArea><placeName><settlement type="city">Stockholm</settlement><region nuts="2">Svealand</region></placeName></affiliation><affiliation wicri:level="4"><nlm:aff id="aff3"><addr-line>Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom</addr-line></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford</wicri:regionArea><placeName><settlement type="city">Oxford</settlement><region type="country">Angleterre</region><region type="comté" nuts="2">Oxfordshire</region><settlement type="city">Oxford</settlement></placeName><orgName type="university">Université d'Oxford</orgName></affiliation></author><author><name sortKey="Prokopenko, Inga" sort="Prokopenko, Inga" uniqKey="Prokopenko I" first="Inga" last="Prokopenko">Inga Prokopenko</name><affiliation wicri:level="4"><nlm:aff id="aff3"><addr-line>Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom</addr-line></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford</wicri:regionArea><placeName><settlement type="city">Oxford</settlement><region type="country">Angleterre</region><region type="comté" nuts="2">Oxfordshire</region><settlement type="city">Oxford</settlement></placeName><orgName type="university">Université d'Oxford</orgName></affiliation><affiliation wicri:level="4"><nlm:aff id="aff5"><addr-line>Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Oxford, United Kingdom</addr-line></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Oxford</wicri:regionArea><placeName><settlement type="city">Oxford</settlement><region type="country">Angleterre</region><region type="comté" nuts="2">Oxfordshire</region><settlement type="city">Oxford</settlement></placeName><orgName type="university">Université d'Oxford</orgName></affiliation><affiliation wicri:level="3"><nlm:aff id="aff82"><addr-line>Department of Genomics of Common Disease, School of Public Health, Imperial College London, London, United Kingdom</addr-line></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Genomics of Common Disease, School of Public Health, Imperial College London, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">23824655</idno><idno type="pmc">3692470</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3692470</idno><idno type="RBID">PMC:3692470</idno><idno type="doi">10.1371/journal.pmed.1001474</idno><date when="2013">2013</date><idno type="wicri:Area/Pmc/Corpus">002895</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">002895</idno><idno type="wicri:Area/Pmc/Curation">002745</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">002745</idno><idno type="wicri:Area/Pmc/Checkpoint">001843</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">001843</idno><idno type="wicri:Area/Ncbi/Merge">001344</idno><idno type="wicri:Area/Ncbi/Curation">001344</idno><idno type="wicri:Area/Ncbi/Checkpoint">001344</idno><idno type="wicri:doubleKey">1549-1277:2013:Fall T:the:role:of</idno><idno type="wicri:Area/Main/Merge">004531</idno><idno type="wicri:Area/Main/Curation">004448</idno><idno type="wicri:Area/Main/Exploration">004448</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">The Role of Adiposity in Cardiometabolic Traits: A Mendelian Randomization Analysis</title><author><name sortKey="Fall, Tove" sort="Fall, Tove" uniqKey="Fall T" first="Tove" last="Fall">Tove Fall</name><affiliation wicri:level="4"><nlm:aff id="aff1"><addr-line>Molecular Epidemiology and Science for Life Laboratory, Department of Medical Sciences, Uppsala University, Uppsala, Sweden</addr-line></nlm:aff><country xml:lang="fr">Suède</country><wicri:regionArea>Molecular Epidemiology and Science for Life Laboratory, Department of Medical Sciences, Uppsala University, Uppsala</wicri:regionArea><orgName type="university">Université d'Uppsala</orgName><placeName><settlement type="city">Uppsala</settlement><region nuts="1">Svealand</region><region nuts="1">East Middle Sweden</region></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="aff2"><addr-line>Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden</addr-line></nlm:aff><country xml:lang="fr">Suède</country><wicri:regionArea>Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm</wicri:regionArea><placeName><settlement type="city">Stockholm</settlement><region nuts="2">Svealand</region></placeName></affiliation></author><author><name sortKey="H Gg, Sara" sort="H Gg, Sara" uniqKey="H Gg S" first="Sara" last="H Gg">Sara H Gg</name><affiliation wicri:level="4"><nlm:aff id="aff1"><addr-line>Molecular Epidemiology and Science for Life Laboratory, Department of Medical Sciences, Uppsala University, Uppsala, Sweden</addr-line></nlm:aff><country xml:lang="fr">Suède</country><wicri:regionArea>Molecular Epidemiology and Science for Life Laboratory, Department of Medical Sciences, Uppsala University, Uppsala</wicri:regionArea><orgName type="university">Université d'Uppsala</orgName><placeName><settlement type="city">Uppsala</settlement><region nuts="1">Svealand</region><region nuts="1">East Middle Sweden</region></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="aff2"><addr-line>Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden</addr-line></nlm:aff><country xml:lang="fr">Suède</country><wicri:regionArea>Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm</wicri:regionArea><placeName><settlement type="city">Stockholm</settlement><region nuts="2">Svealand</region></placeName></affiliation></author><author><name sortKey="M Gi, Reedik" sort="M Gi, Reedik" uniqKey="M Gi R" first="Reedik" last="M Gi">Reedik M Gi</name><affiliation wicri:level="4"><nlm:aff id="aff3"><addr-line>Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom</addr-line></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford</wicri:regionArea><placeName><settlement type="city">Oxford</settlement><region type="country">Angleterre</region><region type="comté" nuts="2">Oxfordshire</region><settlement type="city">Oxford</settlement></placeName><orgName type="university">Université d'Oxford</orgName></affiliation><affiliation wicri:level="1"><nlm:aff id="aff4"><addr-line>Estonian Genome Center, University of Tartu, Tartu, Estonia</addr-line></nlm:aff><country xml:lang="fr">Estonie</country><wicri:regionArea>Estonian Genome Center, University of Tartu, Tartu</wicri:regionArea><wicri:noRegion>Tartu</wicri:noRegion></affiliation></author><author><name sortKey="Ploner, Alexander" sort="Ploner, Alexander" uniqKey="Ploner A" first="Alexander" last="Ploner">Alexander Ploner</name><affiliation wicri:level="3"><nlm:aff id="aff2"><addr-line>Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden</addr-line></nlm:aff><country xml:lang="fr">Suède</country><wicri:regionArea>Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm</wicri:regionArea><placeName><settlement type="city">Stockholm</settlement><region nuts="2">Svealand</region></placeName></affiliation></author><author><name sortKey="Fischer, Krista" sort="Fischer, Krista" uniqKey="Fischer K" first="Krista" last="Fischer">Krista Fischer</name><affiliation wicri:level="1"><nlm:aff id="aff4"><addr-line>Estonian Genome Center, University of Tartu, Tartu, Estonia</addr-line></nlm:aff><country xml:lang="fr">Estonie</country><wicri:regionArea>Estonian Genome Center, University of Tartu, Tartu</wicri:regionArea><wicri:noRegion>Tartu</wicri:noRegion></affiliation></author><author><name sortKey="Horikoshi, Momoko" sort="Horikoshi, Momoko" uniqKey="Horikoshi M" first="Momoko" last="Horikoshi">Momoko Horikoshi</name><affiliation wicri:level="4"><nlm:aff id="aff3"><addr-line>Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom</addr-line></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford</wicri:regionArea><placeName><settlement type="city">Oxford</settlement><region type="country">Angleterre</region><region type="comté" nuts="2">Oxfordshire</region><settlement type="city">Oxford</settlement></placeName><orgName type="university">Université d'Oxford</orgName></affiliation><affiliation wicri:level="4"><nlm:aff id="aff5"><addr-line>Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Oxford, United Kingdom</addr-line></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Oxford</wicri:regionArea><placeName><settlement type="city">Oxford</settlement><region type="country">Angleterre</region><region type="comté" nuts="2">Oxfordshire</region><settlement type="city">Oxford</settlement></placeName><orgName type="university">Université d'Oxford</orgName></affiliation></author><author><name sortKey="Sarin, Antti Pekka" sort="Sarin, Antti Pekka" uniqKey="Sarin A" first="Antti-Pekka" last="Sarin">Antti-Pekka Sarin</name><affiliation wicri:level="4"><nlm:aff id="aff6"><addr-line>Institute for Molecular Medicine Finland, University of Helsinki, Helsinki, Finland</addr-line></nlm:aff><country xml:lang="fr">Finlande</country><wicri:regionArea>Institute for Molecular Medicine Finland, University of Helsinki, Helsinki</wicri:regionArea><orgName type="university">Université d'Helsinki</orgName><placeName><settlement type="city">Helsinki</settlement><region type="région" nuts="2">Uusimaa</region></placeName></affiliation></author><author><name sortKey="Thorleifsson, Gudmar" sort="Thorleifsson, Gudmar" uniqKey="Thorleifsson G" first="Gudmar" last="Thorleifsson">Gudmar Thorleifsson</name><affiliation wicri:level="1"><nlm:aff id="aff7"><addr-line>deCODE Genetics, Reykjavik, Iceland</addr-line></nlm:aff><country xml:lang="fr">Islande</country><wicri:regionArea>deCODE Genetics, Reykjavik</wicri:regionArea><wicri:noRegion>Reykjavik</wicri:noRegion></affiliation></author><author><name sortKey="Ladenvall, Claes" sort="Ladenvall, Claes" uniqKey="Ladenvall C" first="Claes" last="Ladenvall">Claes Ladenvall</name><affiliation wicri:level="1"><nlm:aff id="aff8"><addr-line>Department of Clinical Sciences, Diabetes and Endocrinology, Lund University Diabetes Centre, Lund University and Skåne University Hospital, Malmö, Sweden</addr-line></nlm:aff><country xml:lang="fr">Suède</country><wicri:regionArea>Department of Clinical Sciences, Diabetes and Endocrinology, Lund University Diabetes Centre, Lund University and Skåne University Hospital, Malmö</wicri:regionArea><wicri:noRegion>Malmö</wicri:noRegion></affiliation></author><author><name sortKey="Kals, Mart" sort="Kals, Mart" uniqKey="Kals M" first="Mart" last="Kals">Mart Kals</name><affiliation wicri:level="1"><nlm:aff id="aff4"><addr-line>Estonian Genome Center, University of Tartu, Tartu, Estonia</addr-line></nlm:aff><country xml:lang="fr">Estonie</country><wicri:regionArea>Estonian Genome Center, University of Tartu, Tartu</wicri:regionArea><wicri:noRegion>Tartu</wicri:noRegion></affiliation></author><author><name sortKey="Kuningas, Maris" sort="Kuningas, Maris" uniqKey="Kuningas M" first="Maris" last="Kuningas">Maris Kuningas</name><affiliation wicri:level="3"><nlm:aff id="aff9"><addr-line>Department of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands</addr-line></nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Epidemiology, Erasmus Medical Center, Rotterdam</wicri:regionArea><placeName><settlement type="city">Rotterdam</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation></author><author><name sortKey="Draisma, Harmen H M" sort="Draisma, Harmen H M" uniqKey="Draisma H" first="Harmen H. M." last="Draisma">Harmen H. M. Draisma</name><affiliation wicri:level="3"><nlm:aff id="aff10"><addr-line>Department of Biological Psychology, VU University Amsterdam, Amsterdam, The Netherlands</addr-line></nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Biological Psychology, VU University Amsterdam, Amsterdam</wicri:regionArea><placeName><settlement type="city">Amsterdam</settlement><region nuts="2" type="province">Hollande-Septentrionale</region></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="aff11"><addr-line>The EMGO Institute for Health and Care Research, Amsterdam, The Netherlands</addr-line></nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>The EMGO Institute for Health and Care Research, Amsterdam</wicri:regionArea><placeName><settlement type="city">Amsterdam</settlement><region nuts="2" type="province">Hollande-Septentrionale</region></placeName></affiliation></author><author><name sortKey="Ried, Janina S" sort="Ried, Janina S" uniqKey="Ried J" first="Janina S." last="Ried">Janina S. Ried</name><affiliation wicri:level="1"><nlm:aff id="aff12"><addr-line>Institute of Genetic Epidemiology, Helmholtz Zentrum München—German Research Center for Environmental Health, Neuherberg, Germany</addr-line></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Institute of Genetic Epidemiology, Helmholtz Zentrum München—German Research Center for Environmental Health, Neuherberg</wicri:regionArea><wicri:noRegion>Neuherberg</wicri:noRegion><wicri:noRegion>Neuherberg</wicri:noRegion><wicri:noRegion>Neuherberg</wicri:noRegion></affiliation></author><author><name sortKey="Van Zuydam, Natalie R" sort="Van Zuydam, Natalie R" uniqKey="Van Zuydam N" first="Natalie R." last="Van Zuydam">Natalie R. Van Zuydam</name><affiliation wicri:level="1"><nlm:aff id="aff13"><addr-line>Medical Research Institute, Ninewells Hospital and Medical School, University of Dundee, Dundee, United Kingdom</addr-line></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Medical Research Institute, Ninewells Hospital and Medical School, University of Dundee, Dundee</wicri:regionArea><wicri:noRegion>Dundee</wicri:noRegion></affiliation></author><author><name sortKey="Huikari, Ville" sort="Huikari, Ville" uniqKey="Huikari V" first="Ville" last="Huikari">Ville Huikari</name><affiliation wicri:level="1"><nlm:aff id="aff14"><addr-line>Institute of Health Sciences, University of Oulu, Oulu, Finland</addr-line></nlm:aff><country xml:lang="fr">Finlande</country><wicri:regionArea>Institute of Health Sciences, University of Oulu, Oulu</wicri:regionArea><wicri:noRegion>Oulu</wicri:noRegion></affiliation></author><author><name sortKey="Mangino, Massimo" sort="Mangino, Massimo" uniqKey="Mangino M" first="Massimo" last="Mangino">Massimo Mangino</name><affiliation wicri:level="1"><nlm:aff id="aff15"><addr-line>Department of Twin Research and Genetic Epidemiology, King's College London, United Kingdom</addr-line></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Twin Research and Genetic Epidemiology, King's College London</wicri:regionArea><wicri:noRegion>King's College London</wicri:noRegion></affiliation></author><author><name sortKey="Sonestedt, Emily" sort="Sonestedt, Emily" uniqKey="Sonestedt E" first="Emily" last="Sonestedt">Emily Sonestedt</name><affiliation wicri:level="1"><nlm:aff id="aff16"><addr-line>Diabetes and Cardiovascular Diseases Genetic Epidemiology Research Unit, Department of Clinical Sciences, Skåne University Hospital, Lund University, Malmö, Sweden</addr-line></nlm:aff><country xml:lang="fr">Suède</country><wicri:regionArea>Diabetes and Cardiovascular Diseases Genetic Epidemiology Research Unit, Department of Clinical Sciences, Skåne University Hospital, Lund University, Malmö</wicri:regionArea><wicri:noRegion>Malmö</wicri:noRegion></affiliation></author><author><name sortKey="Benyamin, Beben" sort="Benyamin, Beben" uniqKey="Benyamin B" first="Beben" last="Benyamin">Beben Benyamin</name><affiliation wicri:level="1"><nlm:aff id="aff17"><addr-line>Queensland Institute of Medical Research, Herston, Australia</addr-line></nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Queensland Institute of Medical Research, Herston</wicri:regionArea><wicri:noRegion>Herston</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="aff18"><addr-line>Queensland Brain Institute, University of Queensland, St Lucia, Australia</addr-line></nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Queensland Brain Institute, University of Queensland, St Lucia</wicri:regionArea><wicri:noRegion>St Lucia</wicri:noRegion></affiliation></author><author><name sortKey="Nelson, Christopher P" sort="Nelson, Christopher P" uniqKey="Nelson C" first="Christopher P." last="Nelson">Christopher P. Nelson</name><affiliation wicri:level="1"><nlm:aff id="aff19"><addr-line>Department of Cardiovascular Sciences, University of Leicester, Leicester, United Kingdom</addr-line></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Cardiovascular Sciences, University of Leicester, Leicester</wicri:regionArea><wicri:noRegion>Leicester</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="aff20"><addr-line>National Institute for Health Research, Leicester Cardiovascular Biomedical Research Unit, Glenfield Hospital, Leicester, United Kingdom</addr-line></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>National Institute for Health Research, Leicester Cardiovascular Biomedical Research Unit, Glenfield Hospital, Leicester</wicri:regionArea><wicri:noRegion>Leicester</wicri:noRegion></affiliation></author><author><name sortKey="Rivera, Natalia V" sort="Rivera, Natalia V" uniqKey="Rivera N" first="Natalia V." last="Rivera">Natalia V. Rivera</name><affiliation wicri:level="3"><nlm:aff id="aff21"><addr-line>IRCSS Multimedica, Milan, Italy</addr-line></nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>IRCSS Multimedica, Milan</wicri:regionArea><placeName><settlement type="city">Milan</settlement><region nuts="2">Lombardie</region></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="aff22"><addr-line>Institute of Genetics and Biomedical Research, Consiglio Nazionale delle Ricerche, Milan, Italy</addr-line></nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Institute of Genetics and Biomedical Research, Consiglio Nazionale delle Ricerche, Milan</wicri:regionArea><placeName><settlement type="city">Milan</settlement><region nuts="2">Lombardie</region></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="aff23"><addr-line>Department of Genetic Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands</addr-line></nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Genetic Epidemiology, Erasmus Medical Center, Rotterdam</wicri:regionArea><placeName><settlement type="city">Rotterdam</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation></author><author><name sortKey="Kristiansson, Kati" sort="Kristiansson, Kati" uniqKey="Kristiansson K" first="Kati" last="Kristiansson">Kati Kristiansson</name><affiliation wicri:level="1"><nlm:aff id="aff24"><addr-line>Department of Chronic Disease Prevention, National Institute for Health and Welfare, Helsinki, Finland</addr-line></nlm:aff><country xml:lang="fr">Finlande</country><wicri:regionArea>Department of Chronic Disease Prevention, National Institute for Health and Welfare, Helsinki</wicri:regionArea><wicri:noRegion>Helsinki</wicri:noRegion></affiliation></author><author><name sortKey="Shen, Huei Yi" sort="Shen, Huei Yi" uniqKey="Shen H" first="Huei-Yi" last="Shen">Huei-Yi Shen</name><affiliation wicri:level="4"><nlm:aff id="aff6"><addr-line>Institute for Molecular Medicine Finland, University of Helsinki, Helsinki, Finland</addr-line></nlm:aff><country xml:lang="fr">Finlande</country><wicri:regionArea>Institute for Molecular Medicine Finland, University of Helsinki, Helsinki</wicri:regionArea><orgName type="university">Université d'Helsinki</orgName><placeName><settlement type="city">Helsinki</settlement><region type="région" nuts="2">Uusimaa</region></placeName></affiliation><affiliation wicri:level="1"><nlm:aff id="aff25"><addr-line>Public Health Genomics Unit, National Institute for Health and Welfare, Helsinki, Finland</addr-line></nlm:aff><country xml:lang="fr">Finlande</country><wicri:regionArea>Public Health Genomics Unit, National Institute for Health and Welfare, Helsinki</wicri:regionArea><wicri:noRegion>Helsinki</wicri:noRegion></affiliation></author><author><name sortKey="Havulinna, Aki S" sort="Havulinna, Aki S" uniqKey="Havulinna A" first="Aki S." last="Havulinna">Aki S. Havulinna</name><affiliation wicri:level="1"><nlm:aff id="aff24"><addr-line>Department of Chronic Disease Prevention, National Institute for Health and Welfare, Helsinki, Finland</addr-line></nlm:aff><country xml:lang="fr">Finlande</country><wicri:regionArea>Department of Chronic Disease Prevention, National Institute for Health and Welfare, Helsinki</wicri:regionArea><wicri:noRegion>Helsinki</wicri:noRegion></affiliation></author><author><name sortKey="Dehghan, Abbas" sort="Dehghan, Abbas" uniqKey="Dehghan A" first="Abbas" last="Dehghan">Abbas Dehghan</name><affiliation wicri:level="3"><nlm:aff id="aff9"><addr-line>Department of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands</addr-line></nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Epidemiology, Erasmus Medical Center, Rotterdam</wicri:regionArea><placeName><settlement type="city">Rotterdam</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="aff26"><addr-line>Netherlands Consortium for Healthy Ageing, Netherlands Genomics Initiative, Leiden, The Netherlands</addr-line></nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Netherlands Consortium for Healthy Ageing, Netherlands Genomics Initiative, Leiden</wicri:regionArea><placeName><settlement type="city">Leyde</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation></author><author><name sortKey="Donnelly, Louise A" sort="Donnelly, Louise A" uniqKey="Donnelly L" first="Louise A." last="Donnelly">Louise A. Donnelly</name><affiliation wicri:level="1"><nlm:aff id="aff13"><addr-line>Medical Research Institute, Ninewells Hospital and Medical School, University of Dundee, Dundee, United Kingdom</addr-line></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Medical Research Institute, Ninewells Hospital and Medical School, University of Dundee, Dundee</wicri:regionArea><wicri:noRegion>Dundee</wicri:noRegion></affiliation></author><author><name sortKey="Kaakinen, Marika" sort="Kaakinen, Marika" uniqKey="Kaakinen M" first="Marika" last="Kaakinen">Marika Kaakinen</name><affiliation wicri:level="1"><nlm:aff id="aff14"><addr-line>Institute of Health Sciences, University of Oulu, Oulu, Finland</addr-line></nlm:aff><country xml:lang="fr">Finlande</country><wicri:regionArea>Institute of Health Sciences, University of Oulu, Oulu</wicri:regionArea><wicri:noRegion>Oulu</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="aff27"><addr-line>Biocenter Oulu, University of Oulu, Oulu, Finland</addr-line></nlm:aff><country xml:lang="fr">Finlande</country><wicri:regionArea>Biocenter Oulu, University of Oulu, Oulu</wicri:regionArea><wicri:noRegion>Oulu</wicri:noRegion></affiliation></author><author><name sortKey="Nuotio, Marja Liisa" sort="Nuotio, Marja Liisa" uniqKey="Nuotio M" first="Marja-Liisa" last="Nuotio">Marja-Liisa Nuotio</name><affiliation wicri:level="1"><nlm:aff id="aff24"><addr-line>Department of Chronic Disease Prevention, National Institute for Health and Welfare, Helsinki, Finland</addr-line></nlm:aff><country xml:lang="fr">Finlande</country><wicri:regionArea>Department of Chronic Disease Prevention, National Institute for Health and Welfare, Helsinki</wicri:regionArea><wicri:noRegion>Helsinki</wicri:noRegion></affiliation></author><author><name sortKey="Robertson, Neil" sort="Robertson, Neil" uniqKey="Robertson N" first="Neil" last="Robertson">Neil Robertson</name><affiliation wicri:level="4"><nlm:aff id="aff3"><addr-line>Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom</addr-line></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford</wicri:regionArea><placeName><settlement type="city">Oxford</settlement><region type="country">Angleterre</region><region type="comté" nuts="2">Oxfordshire</region><settlement type="city">Oxford</settlement></placeName><orgName type="university">Université d'Oxford</orgName></affiliation><affiliation wicri:level="4"><nlm:aff id="aff5"><addr-line>Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Oxford, United Kingdom</addr-line></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Oxford</wicri:regionArea><placeName><settlement type="city">Oxford</settlement><region type="country">Angleterre</region><region type="comté" nuts="2">Oxfordshire</region><settlement type="city">Oxford</settlement></placeName><orgName type="university">Université d'Oxford</orgName></affiliation></author><author><name sortKey="De Bruijn, Renee F A G" sort="De Bruijn, Renee F A G" uniqKey="De Bruijn R" first="Renée F. A. G." last="De Bruijn">Renée F. A. G. De Bruijn</name><affiliation wicri:level="3"><nlm:aff id="aff9"><addr-line>Department of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands</addr-line></nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Epidemiology, Erasmus Medical Center, Rotterdam</wicri:regionArea><placeName><settlement type="city">Rotterdam</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="aff28"><addr-line>Department of Neurology, Erasmus Medical Center, Rotterdam, The Netherlands</addr-line></nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Neurology, Erasmus Medical Center, Rotterdam</wicri:regionArea><placeName><settlement type="city">Rotterdam</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation></author><author><name sortKey="Ikram, M Arfan" sort="Ikram, M Arfan" uniqKey="Ikram M" first="M. Arfan" last="Ikram">M. Arfan Ikram</name><affiliation wicri:level="3"><nlm:aff id="aff9"><addr-line>Department of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands</addr-line></nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Epidemiology, Erasmus Medical Center, Rotterdam</wicri:regionArea><placeName><settlement type="city">Rotterdam</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="aff28"><addr-line>Department of Neurology, Erasmus Medical Center, Rotterdam, The Netherlands</addr-line></nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Neurology, Erasmus Medical Center, Rotterdam</wicri:regionArea><placeName><settlement type="city">Rotterdam</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="aff29"><addr-line>Department of Radiology, Erasmus Medical Center, Rotterdam, The Netherlands</addr-line></nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Radiology, Erasmus Medical Center, Rotterdam</wicri:regionArea><placeName><settlement type="city">Rotterdam</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation></author><author><name sortKey="Amin, Najaf" sort="Amin, Najaf" uniqKey="Amin N" first="Najaf" last="Amin">Najaf Amin</name><affiliation wicri:level="3"><nlm:aff id="aff23"><addr-line>Department of Genetic Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands</addr-line></nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Genetic Epidemiology, Erasmus Medical Center, Rotterdam</wicri:regionArea><placeName><settlement type="city">Rotterdam</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation></author><author><name sortKey="Balmforth, Anthony J" sort="Balmforth, Anthony J" uniqKey="Balmforth A" first="Anthony J." last="Balmforth">Anthony J. Balmforth</name><affiliation wicri:level="4"><nlm:aff id="aff30"><addr-line>Division of Epidemiology, Leeds Institute of Genetics, Health and Therapeutics, School of Medicine, University of Leeds, Leeds, United Kingdom</addr-line></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Division of Epidemiology, Leeds Institute of Genetics, Health and Therapeutics, School of Medicine, University of Leeds, Leeds</wicri:regionArea><orgName type="university">Université de Leeds</orgName><placeName><settlement type="city">Leeds</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Yorkshire-et-Humber</region></placeName></affiliation></author><author><name sortKey="Braund, Peter S" sort="Braund, Peter S" uniqKey="Braund P" first="Peter S." last="Braund">Peter S. Braund</name><affiliation wicri:level="1"><nlm:aff id="aff19"><addr-line>Department of Cardiovascular Sciences, University of Leicester, Leicester, United Kingdom</addr-line></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Cardiovascular Sciences, University of Leicester, Leicester</wicri:regionArea><wicri:noRegion>Leicester</wicri:noRegion></affiliation></author><author><name sortKey="Doney, Alexander S F" sort="Doney, Alexander S F" uniqKey="Doney A" first="Alexander S. F." last="Doney">Alexander S. F. Doney</name><affiliation wicri:level="1"><nlm:aff id="aff13"><addr-line>Medical Research Institute, Ninewells Hospital and Medical School, University of Dundee, Dundee, United Kingdom</addr-line></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Medical Research Institute, Ninewells Hospital and Medical School, University of Dundee, Dundee</wicri:regionArea><wicri:noRegion>Dundee</wicri:noRegion></affiliation></author><author><name sortKey="Doring, Angela" sort="Doring, Angela" uniqKey="Doring A" first="Angela" last="Döring">Angela Döring</name><affiliation wicri:level="1"><nlm:aff id="aff31"><addr-line>Institute of Epidemiology I, Helmholtz Zentrum München—German Research Center for Environmental Health, Neuherberg, Germany</addr-line></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Institute of Epidemiology I, Helmholtz Zentrum München—German Research Center for Environmental Health, Neuherberg</wicri:regionArea><wicri:noRegion>Neuherberg</wicri:noRegion><wicri:noRegion>Neuherberg</wicri:noRegion><wicri:noRegion>Neuherberg</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="aff32"><addr-line>Institute of Epidemiology II, Helmholtz Zentrum München—German Research Center for Environmental Health, Neuherberg, Germany</addr-line></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Institute of Epidemiology II, Helmholtz Zentrum München—German Research Center for Environmental Health, Neuherberg</wicri:regionArea><wicri:noRegion>Neuherberg</wicri:noRegion><wicri:noRegion>Neuherberg</wicri:noRegion><wicri:noRegion>Neuherberg</wicri:noRegion></affiliation></author><author><name sortKey="Elliott, Paul" sort="Elliott, Paul" uniqKey="Elliott P" first="Paul" last="Elliott">Paul Elliott</name><affiliation wicri:level="3"><nlm:aff id="aff33"><addr-line>MRC-HPA Centre for Environment and Health, Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, United Kingdom</addr-line></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>MRC-HPA Centre for Environment and Health, Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Esko, T Nu" sort="Esko, T Nu" uniqKey="Esko T" first="T Nu" last="Esko">T Nu Esko</name><affiliation wicri:level="1"><nlm:aff id="aff4"><addr-line>Estonian Genome Center, University of Tartu, Tartu, Estonia</addr-line></nlm:aff><country xml:lang="fr">Estonie</country><wicri:regionArea>Estonian Genome Center, University of Tartu, Tartu</wicri:regionArea><wicri:noRegion>Tartu</wicri:noRegion></affiliation></author><author><name sortKey="Franco, Oscar H" sort="Franco, Oscar H" uniqKey="Franco O" first="Oscar H." last="Franco">Oscar H. Franco</name><affiliation wicri:level="3"><nlm:aff id="aff9"><addr-line>Department of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands</addr-line></nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Epidemiology, Erasmus Medical Center, Rotterdam</wicri:regionArea><placeName><settlement type="city">Rotterdam</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="aff26"><addr-line>Netherlands Consortium for Healthy Ageing, Netherlands Genomics Initiative, Leiden, The Netherlands</addr-line></nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Netherlands Consortium for Healthy Ageing, Netherlands Genomics Initiative, Leiden</wicri:regionArea><placeName><settlement type="city">Leyde</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation></author><author><name sortKey="Gretarsdottir, Solveig" sort="Gretarsdottir, Solveig" uniqKey="Gretarsdottir S" first="Solveig" last="Gretarsdottir">Solveig Gretarsdottir</name><affiliation wicri:level="1"><nlm:aff id="aff7"><addr-line>deCODE Genetics, Reykjavik, Iceland</addr-line></nlm:aff><country xml:lang="fr">Islande</country><wicri:regionArea>deCODE Genetics, Reykjavik</wicri:regionArea><wicri:noRegion>Reykjavik</wicri:noRegion></affiliation></author><author><name sortKey="Hartikainen, Anna Liisa" sort="Hartikainen, Anna Liisa" uniqKey="Hartikainen A" first="Anna-Liisa" last="Hartikainen">Anna-Liisa Hartikainen</name><affiliation wicri:level="1"><nlm:aff id="aff34"><addr-line>Department of Obstetrics and Gynaecology, Institute of Clinical Sciences, University of Oulu, Oulu, Finland</addr-line></nlm:aff><country xml:lang="fr">Finlande</country><wicri:regionArea>Department of Obstetrics and Gynaecology, Institute of Clinical Sciences, University of Oulu, Oulu</wicri:regionArea><wicri:noRegion>Oulu</wicri:noRegion></affiliation></author><author><name sortKey="Heikkil, Kauko" sort="Heikkil, Kauko" uniqKey="Heikkil K" first="Kauko" last="Heikkil">Kauko Heikkil</name><affiliation wicri:level="4"><nlm:aff id="aff35"><addr-line>Department of Public Health, Hjelt Institute, University of Helsinki, Helsinki, Finland</addr-line></nlm:aff><country xml:lang="fr">Finlande</country><wicri:regionArea>Department of Public Health, Hjelt Institute, University of Helsinki, Helsinki</wicri:regionArea><orgName type="university">Université d'Helsinki</orgName><placeName><settlement type="city">Helsinki</settlement><region type="région" nuts="2">Uusimaa</region></placeName></affiliation></author><author><name sortKey="Herzig, Karl Heinz" sort="Herzig, Karl Heinz" uniqKey="Herzig K" first="Karl-Heinz" last="Herzig">Karl-Heinz Herzig</name><affiliation wicri:level="1"><nlm:aff id="aff27"><addr-line>Biocenter Oulu, University of Oulu, Oulu, Finland</addr-line></nlm:aff><country xml:lang="fr">Finlande</country><wicri:regionArea>Biocenter Oulu, University of Oulu, Oulu</wicri:regionArea><wicri:noRegion>Oulu</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="aff36"><addr-line>Institute of Biomedicine, University of Oulu, Oulu, Finland</addr-line></nlm:aff><country xml:lang="fr">Finlande</country><wicri:regionArea>Institute of Biomedicine, University of Oulu, Oulu</wicri:regionArea><wicri:noRegion>Oulu</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="aff37"><addr-line>Department of Psychiatry, Kuopio University Hospital, Kuopio, Finland</addr-line></nlm:aff><country xml:lang="fr">Finlande</country><wicri:regionArea>Department of Psychiatry, Kuopio University Hospital, Kuopio</wicri:regionArea><wicri:noRegion>Kuopio</wicri:noRegion></affiliation></author><author><name sortKey="Holm, Hilma" sort="Holm, Hilma" uniqKey="Holm H" first="Hilma" last="Holm">Hilma Holm</name><affiliation wicri:level="1"><nlm:aff id="aff7"><addr-line>deCODE Genetics, Reykjavik, Iceland</addr-line></nlm:aff><country xml:lang="fr">Islande</country><wicri:regionArea>deCODE Genetics, Reykjavik</wicri:regionArea><wicri:noRegion>Reykjavik</wicri:noRegion></affiliation></author><author><name sortKey="Hottenga, Jouke Jan" sort="Hottenga, Jouke Jan" uniqKey="Hottenga J" first="Jouke Jan" last="Hottenga">Jouke Jan Hottenga</name><affiliation wicri:level="3"><nlm:aff id="aff10"><addr-line>Department of Biological Psychology, VU University Amsterdam, Amsterdam, The Netherlands</addr-line></nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Biological Psychology, VU University Amsterdam, Amsterdam</wicri:regionArea><placeName><settlement type="city">Amsterdam</settlement><region nuts="2" type="province">Hollande-Septentrionale</region></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="aff11"><addr-line>The EMGO Institute for Health and Care Research, Amsterdam, The Netherlands</addr-line></nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>The EMGO Institute for Health and Care Research, Amsterdam</wicri:regionArea><placeName><settlement type="city">Amsterdam</settlement><region nuts="2" type="province">Hollande-Septentrionale</region></placeName></affiliation></author><author><name sortKey="Hypponen, Elina" sort="Hypponen, Elina" uniqKey="Hypponen E" first="Elina" last="Hyppönen">Elina Hyppönen</name><affiliation wicri:level="3"><nlm:aff id="aff38"><addr-line>Centre for Paediatric Epidemiology and Biostatistics and Medical Research Council Centre for the Epidemiology of Child Health, University College London Institute of Child Health, London, United Kingdom</addr-line></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Centre for Paediatric Epidemiology and Biostatistics and Medical Research Council Centre for the Epidemiology of Child Health, University College London Institute of Child Health, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Illig, Thomas" sort="Illig, Thomas" uniqKey="Illig T" first="Thomas" last="Illig">Thomas Illig</name><affiliation wicri:level="3"><nlm:aff id="aff39"><addr-line>Hannover Unified Biobank, Hannover Medical School, Hannover, Germany</addr-line></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Hannover Unified Biobank, Hannover Medical School, Hannover</wicri:regionArea><placeName><region type="land" nuts="2">Basse-Saxe</region><settlement type="city">Hanovre</settlement></placeName></affiliation><affiliation wicri:level="1"><nlm:aff id="aff40"><addr-line>Research Unit of Molecular Epidemiology, Helmholtz Zentrum München—German Research Center for Environmental Health, Neuherberg, Germany</addr-line></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Research Unit of Molecular Epidemiology, Helmholtz Zentrum München—German Research Center for Environmental Health, Neuherberg</wicri:regionArea><wicri:noRegion>Neuherberg</wicri:noRegion><wicri:noRegion>Neuherberg</wicri:noRegion><wicri:noRegion>Neuherberg</wicri:noRegion></affiliation></author><author><name sortKey="Isaacs, Aaron" sort="Isaacs, Aaron" uniqKey="Isaacs A" first="Aaron" last="Isaacs">Aaron Isaacs</name><affiliation wicri:level="3"><nlm:aff id="aff23"><addr-line>Department of Genetic Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands</addr-line></nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Genetic Epidemiology, Erasmus Medical Center, Rotterdam</wicri:regionArea><placeName><settlement type="city">Rotterdam</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation></author><author><name sortKey="Isomaa, Bo" sort="Isomaa, Bo" uniqKey="Isomaa B" first="Bo" last="Isomaa">Bo Isomaa</name><affiliation wicri:level="1"><nlm:aff id="aff41"><addr-line>Department of Social Services and Health Care, Jakobstad, Finland</addr-line></nlm:aff><country xml:lang="fr">Finlande</country><wicri:regionArea>Department of Social Services and Health Care, Jakobstad</wicri:regionArea><wicri:noRegion>Jakobstad</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="aff42"><addr-line>Folkhälsan Research Centre, Helsinki, Finland</addr-line></nlm:aff><country xml:lang="fr">Finlande</country><wicri:regionArea>Folkhälsan Research Centre, Helsinki</wicri:regionArea><wicri:noRegion>Helsinki</wicri:noRegion></affiliation></author><author><name sortKey="Karssen, Lennart C" sort="Karssen, Lennart C" uniqKey="Karssen L" first="Lennart C." last="Karssen">Lennart C. Karssen</name><affiliation wicri:level="3"><nlm:aff id="aff23"><addr-line>Department of Genetic Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands</addr-line></nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Genetic Epidemiology, Erasmus Medical Center, Rotterdam</wicri:regionArea><placeName><settlement type="city">Rotterdam</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation></author><author><name sortKey="Kettunen, Johannes" sort="Kettunen, Johannes" uniqKey="Kettunen J" first="Johannes" last="Kettunen">Johannes Kettunen</name><affiliation wicri:level="4"><nlm:aff id="aff6"><addr-line>Institute for Molecular Medicine Finland, University of Helsinki, Helsinki, Finland</addr-line></nlm:aff><country xml:lang="fr">Finlande</country><wicri:regionArea>Institute for Molecular Medicine Finland, University of Helsinki, Helsinki</wicri:regionArea><orgName type="university">Université d'Helsinki</orgName><placeName><settlement type="city">Helsinki</settlement><region type="région" nuts="2">Uusimaa</region></placeName></affiliation><affiliation wicri:level="1"><nlm:aff id="aff24"><addr-line>Department of Chronic Disease Prevention, National Institute for Health and Welfare, Helsinki, Finland</addr-line></nlm:aff><country xml:lang="fr">Finlande</country><wicri:regionArea>Department of Chronic Disease Prevention, National Institute for Health and Welfare, Helsinki</wicri:regionArea><wicri:noRegion>Helsinki</wicri:noRegion></affiliation></author><author><name sortKey="Koenig, Wolfgang" sort="Koenig, Wolfgang" uniqKey="Koenig W" first="Wolfgang" last="Koenig">Wolfgang Koenig</name><affiliation wicri:level="3"><nlm:aff id="aff43"><addr-line>Department of Internal Medicine II–Cardiology, University of Ulm Medical Center, Ulm, Germany</addr-line></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Internal Medicine II–Cardiology, University of Ulm Medical Center, Ulm</wicri:regionArea><placeName><region type="land" nuts="1">Bade-Wurtemberg</region><region type="district" nuts="2">District de Tübingen</region><settlement type="city">Ulm</settlement></placeName></affiliation></author><author><name sortKey="Kuulasmaa, Kari" sort="Kuulasmaa, Kari" uniqKey="Kuulasmaa K" first="Kari" last="Kuulasmaa">Kari Kuulasmaa</name><affiliation wicri:level="1"><nlm:aff id="aff24"><addr-line>Department of Chronic Disease Prevention, National Institute for Health and Welfare, Helsinki, Finland</addr-line></nlm:aff><country xml:lang="fr">Finlande</country><wicri:regionArea>Department of Chronic Disease Prevention, National Institute for Health and Welfare, Helsinki</wicri:regionArea><wicri:noRegion>Helsinki</wicri:noRegion></affiliation></author><author><name sortKey="Laatikainen, Tiina" sort="Laatikainen, Tiina" uniqKey="Laatikainen T" first="Tiina" last="Laatikainen">Tiina Laatikainen</name><affiliation wicri:level="1"><nlm:aff id="aff24"><addr-line>Department of Chronic Disease Prevention, National Institute for Health and Welfare, Helsinki, Finland</addr-line></nlm:aff><country xml:lang="fr">Finlande</country><wicri:regionArea>Department of Chronic Disease Prevention, National Institute for Health and Welfare, Helsinki</wicri:regionArea><wicri:noRegion>Helsinki</wicri:noRegion></affiliation></author><author><name sortKey="Laitinen, Jaana" sort="Laitinen, Jaana" uniqKey="Laitinen J" first="Jaana" last="Laitinen">Jaana Laitinen</name><affiliation wicri:level="1"><nlm:aff id="aff44"><addr-line>Finnish Institute of Occupational Health, Helsinki, Finland</addr-line></nlm:aff><country xml:lang="fr">Finlande</country><wicri:regionArea>Finnish Institute of Occupational Health, Helsinki</wicri:regionArea><wicri:noRegion>Helsinki</wicri:noRegion></affiliation></author><author><name sortKey="Lindgren, Cecilia" sort="Lindgren, Cecilia" uniqKey="Lindgren C" first="Cecilia" last="Lindgren">Cecilia Lindgren</name><affiliation wicri:level="4"><nlm:aff id="aff3"><addr-line>Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom</addr-line></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford</wicri:regionArea><placeName><settlement type="city">Oxford</settlement><region type="country">Angleterre</region><region type="comté" nuts="2">Oxfordshire</region><settlement type="city">Oxford</settlement></placeName><orgName type="university">Université d'Oxford</orgName></affiliation></author><author><name sortKey="Lyssenko, Valeriya" sort="Lyssenko, Valeriya" uniqKey="Lyssenko V" first="Valeriya" last="Lyssenko">Valeriya Lyssenko</name><affiliation wicri:level="1"><nlm:aff id="aff8"><addr-line>Department of Clinical Sciences, Diabetes and Endocrinology, Lund University Diabetes Centre, Lund University and Skåne University Hospital, Malmö, Sweden</addr-line></nlm:aff><country xml:lang="fr">Suède</country><wicri:regionArea>Department of Clinical Sciences, Diabetes and Endocrinology, Lund University Diabetes Centre, Lund University and Skåne University Hospital, Malmö</wicri:regionArea><wicri:noRegion>Malmö</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="aff45"><addr-line>Steno Diabetes Center, Gentofte, Denmark</addr-line></nlm:aff><country xml:lang="fr">Danemark</country><wicri:regionArea>Steno Diabetes Center, Gentofte</wicri:regionArea><wicri:noRegion>Gentofte</wicri:noRegion></affiliation></author><author><name sortKey="L R, Esa" sort="L R, Esa" uniqKey="L R E" first="Esa" last="L R">Esa L R</name><affiliation wicri:level="1"><nlm:aff id="aff46"><addr-line>Department of Mathematical Sciences, University of Oulu, Oulu, Finland</addr-line></nlm:aff><country xml:lang="fr">Finlande</country><wicri:regionArea>Department of Mathematical Sciences, University of Oulu, Oulu</wicri:regionArea><wicri:noRegion>Oulu</wicri:noRegion></affiliation></author><author><name sortKey="Rayner, Nigel W" sort="Rayner, Nigel W" uniqKey="Rayner N" first="Nigel W." last="Rayner">Nigel W. Rayner</name><affiliation wicri:level="4"><nlm:aff id="aff3"><addr-line>Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom</addr-line></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford</wicri:regionArea><placeName><settlement type="city">Oxford</settlement><region type="country">Angleterre</region><region type="comté" nuts="2">Oxfordshire</region><settlement type="city">Oxford</settlement></placeName><orgName type="university">Université d'Oxford</orgName></affiliation><affiliation wicri:level="4"><nlm:aff id="aff5"><addr-line>Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Oxford, United Kingdom</addr-line></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Oxford</wicri:regionArea><placeName><settlement type="city">Oxford</settlement><region type="country">Angleterre</region><region type="comté" nuts="2">Oxfordshire</region><settlement type="city">Oxford</settlement></placeName><orgName type="university">Université d'Oxford</orgName></affiliation><affiliation wicri:level="1"><nlm:aff id="aff47"><addr-line>Wellcome Trust Sanger Institute, Hinxton, United Kingdom</addr-line></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Wellcome Trust Sanger Institute, Hinxton</wicri:regionArea><wicri:noRegion>Hinxton</wicri:noRegion></affiliation></author><author><name sortKey="M Nnisto, Satu" sort="M Nnisto, Satu" uniqKey="M Nnisto S" first="Satu" last="M Nnistö">Satu M Nnistö</name><affiliation wicri:level="1"><nlm:aff id="aff24"><addr-line>Department of Chronic Disease Prevention, National Institute for Health and Welfare, Helsinki, Finland</addr-line></nlm:aff><country xml:lang="fr">Finlande</country><wicri:regionArea>Department of Chronic Disease Prevention, National Institute for Health and Welfare, Helsinki</wicri:regionArea><wicri:noRegion>Helsinki</wicri:noRegion></affiliation></author><author><name sortKey="Pouta, Anneli" sort="Pouta, Anneli" uniqKey="Pouta A" first="Anneli" last="Pouta">Anneli Pouta</name><affiliation wicri:level="1"><nlm:aff id="aff34"><addr-line>Department of Obstetrics and Gynaecology, Institute of Clinical Sciences, University of Oulu, Oulu, Finland</addr-line></nlm:aff><country xml:lang="fr">Finlande</country><wicri:regionArea>Department of Obstetrics and Gynaecology, Institute of Clinical Sciences, University of Oulu, Oulu</wicri:regionArea><wicri:noRegion>Oulu</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="aff48"><addr-line>Department of Children, Young People and Families, National Institute for Health and Welfare, Oulu, Finland</addr-line></nlm:aff><country xml:lang="fr">Finlande</country><wicri:regionArea>Department of Children, Young People and Families, National Institute for Health and Welfare, Oulu</wicri:regionArea><wicri:noRegion>Oulu</wicri:noRegion></affiliation></author><author><name sortKey="Rathmann, Wolfgang" sort="Rathmann, Wolfgang" uniqKey="Rathmann W" first="Wolfgang" last="Rathmann">Wolfgang Rathmann</name><affiliation wicri:level="3"><nlm:aff id="aff49"><addr-line>Institute of Biometrics and Epidemiology, German Diabetes Center, Düsseldorf University, Düsseldorf, Germany</addr-line></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Institute of Biometrics and Epidemiology, German Diabetes Center, Düsseldorf University, Düsseldorf</wicri:regionArea><placeName><region type="land" nuts="1">Rhénanie-du-Nord-Westphalie</region><region type="district" nuts="2">District de Düsseldorf</region><settlement type="city">Düsseldorf</settlement></placeName></affiliation></author><author><name sortKey="Rivadeneira, Fernando" sort="Rivadeneira, Fernando" uniqKey="Rivadeneira F" first="Fernando" last="Rivadeneira">Fernando Rivadeneira</name><affiliation wicri:level="3"><nlm:aff id="aff26"><addr-line>Netherlands Consortium for Healthy Ageing, Netherlands Genomics Initiative, Leiden, The Netherlands</addr-line></nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Netherlands Consortium for Healthy Ageing, Netherlands Genomics Initiative, Leiden</wicri:regionArea><placeName><settlement type="city">Leyde</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="aff50"><addr-line>Department of Internal Medicine, Erasmus Medical Center, Rotterdam, The Netherlands</addr-line></nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Internal Medicine, Erasmus Medical Center, Rotterdam</wicri:regionArea><placeName><settlement type="city">Rotterdam</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation></author><author><name sortKey="Ruokonen, Aimo" sort="Ruokonen, Aimo" uniqKey="Ruokonen A" first="Aimo" last="Ruokonen">Aimo Ruokonen</name><affiliation wicri:level="1"><nlm:aff id="aff51"><addr-line>Institute of Diagnostics, University of Oulu, Oulu, Finland</addr-line></nlm:aff><country xml:lang="fr">Finlande</country><wicri:regionArea>Institute of Diagnostics, University of Oulu, Oulu</wicri:regionArea><wicri:noRegion>Oulu</wicri:noRegion></affiliation></author><author><name sortKey="Savolainen, Markku J" sort="Savolainen, Markku J" uniqKey="Savolainen M" first="Markku J." last="Savolainen">Markku J. Savolainen</name><affiliation wicri:level="1"><nlm:aff id="aff27"><addr-line>Biocenter Oulu, University of Oulu, Oulu, Finland</addr-line></nlm:aff><country xml:lang="fr">Finlande</country><wicri:regionArea>Biocenter Oulu, University of Oulu, Oulu</wicri:regionArea><wicri:noRegion>Oulu</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="aff52"><addr-line>Department of Internal Medicine, Institute of Clinical Medicine, University of Oulu, Oulu, Finland</addr-line></nlm:aff><country xml:lang="fr">Finlande</country><wicri:regionArea>Department of Internal Medicine, Institute of Clinical Medicine, University of Oulu, Oulu</wicri:regionArea><wicri:noRegion>Oulu</wicri:noRegion></affiliation></author><author><name sortKey="Sijbrands, Eric J G" sort="Sijbrands, Eric J G" uniqKey="Sijbrands E" first="Eric J. G." last="Sijbrands">Eric J. G. Sijbrands</name><affiliation wicri:level="3"><nlm:aff id="aff50"><addr-line>Department of Internal Medicine, Erasmus Medical Center, Rotterdam, The Netherlands</addr-line></nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Internal Medicine, Erasmus Medical Center, Rotterdam</wicri:regionArea><placeName><settlement type="city">Rotterdam</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation></author><author><name sortKey="Small, Kerrin S" sort="Small, Kerrin S" uniqKey="Small K" first="Kerrin S." last="Small">Kerrin S. Small</name><affiliation wicri:level="1"><nlm:aff id="aff15"><addr-line>Department of Twin Research and Genetic Epidemiology, King's College London, United Kingdom</addr-line></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Twin Research and Genetic Epidemiology, King's College London</wicri:regionArea><wicri:noRegion>King's College London</wicri:noRegion></affiliation></author><author><name sortKey="Smit, Jan H" sort="Smit, Jan H" uniqKey="Smit J" first="Jan H." last="Smit">Jan H. Smit</name><affiliation wicri:level="3"><nlm:aff id="aff11"><addr-line>The EMGO Institute for Health and Care Research, Amsterdam, The Netherlands</addr-line></nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>The EMGO Institute for Health and Care Research, Amsterdam</wicri:regionArea><placeName><settlement type="city">Amsterdam</settlement><region nuts="2" type="province">Hollande-Septentrionale</region></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="aff53"><addr-line>Neuroscience Campus Amsterdam, Amsterdam, The Netherlands</addr-line></nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Neuroscience Campus Amsterdam, Amsterdam</wicri:regionArea><placeName><settlement type="city">Amsterdam</settlement><region nuts="2" type="province">Hollande-Septentrionale</region></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="aff54"><addr-line>Department of Psychiatry, VU University Medical Center, Amsterdam, The Netherlands</addr-line></nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Psychiatry, VU University Medical Center, Amsterdam</wicri:regionArea><placeName><settlement type="city">Amsterdam</settlement><region nuts="2" type="province">Hollande-Septentrionale</region></placeName></affiliation></author><author><name sortKey="Steinthorsdottir, Valgerdur" sort="Steinthorsdottir, Valgerdur" uniqKey="Steinthorsdottir V" first="Valgerdur" last="Steinthorsdottir">Valgerdur Steinthorsdottir</name><affiliation wicri:level="1"><nlm:aff id="aff7"><addr-line>deCODE Genetics, Reykjavik, Iceland</addr-line></nlm:aff><country xml:lang="fr">Islande</country><wicri:regionArea>deCODE Genetics, Reykjavik</wicri:regionArea><wicri:noRegion>Reykjavik</wicri:noRegion></affiliation></author><author><name sortKey="Syv Nen, Ann Christine" sort="Syv Nen, Ann Christine" uniqKey="Syv Nen A" first="Ann-Christine" last="Syv Nen">Ann-Christine Syv Nen</name><affiliation wicri:level="4"><nlm:aff id="aff55"><addr-line>Molecular Medicine and Science for Life Laboratory, Department of Medical Sciences, Uppsala University, Uppsala, Sweden</addr-line></nlm:aff><country xml:lang="fr">Suède</country><wicri:regionArea>Molecular Medicine and Science for Life Laboratory, Department of Medical Sciences, Uppsala University, Uppsala</wicri:regionArea><orgName type="university">Université d'Uppsala</orgName><placeName><settlement type="city">Uppsala</settlement><region nuts="1">Svealand</region><region nuts="1">East Middle Sweden</region></placeName></affiliation></author><author><name sortKey="Taanila, Anja" sort="Taanila, Anja" uniqKey="Taanila A" first="Anja" last="Taanila">Anja Taanila</name><affiliation wicri:level="1"><nlm:aff id="aff14"><addr-line>Institute of Health Sciences, University of Oulu, Oulu, Finland</addr-line></nlm:aff><country xml:lang="fr">Finlande</country><wicri:regionArea>Institute of Health Sciences, University of Oulu, Oulu</wicri:regionArea><wicri:noRegion>Oulu</wicri:noRegion></affiliation></author><author><name sortKey="Tobin, Martin D" sort="Tobin, Martin D" uniqKey="Tobin M" first="Martin D." last="Tobin">Martin D. Tobin</name><affiliation wicri:level="1"><nlm:aff id="aff56"><addr-line>Department of Health Sciences, University of Leicester, Leicester, United Kingdom</addr-line></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Health Sciences, University of Leicester, Leicester</wicri:regionArea><wicri:noRegion>Leicester</wicri:noRegion></affiliation></author><author><name sortKey="Uitterlinden, Andre G" sort="Uitterlinden, Andre G" uniqKey="Uitterlinden A" first="Andre G." last="Uitterlinden">Andre G. Uitterlinden</name><affiliation wicri:level="3"><nlm:aff id="aff50"><addr-line>Department of Internal Medicine, Erasmus Medical Center, Rotterdam, The Netherlands</addr-line></nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Internal Medicine, Erasmus Medical Center, Rotterdam</wicri:regionArea><placeName><settlement type="city">Rotterdam</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation></author><author><name sortKey="Willems, Sara M" sort="Willems, Sara M" uniqKey="Willems S" first="Sara M." last="Willems">Sara M. Willems</name><affiliation wicri:level="3"><nlm:aff id="aff23"><addr-line>Department of Genetic Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands</addr-line></nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Genetic Epidemiology, Erasmus Medical Center, Rotterdam</wicri:regionArea><placeName><settlement type="city">Rotterdam</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation></author><author><name sortKey="Willemsen, Gonneke" sort="Willemsen, Gonneke" uniqKey="Willemsen G" first="Gonneke" last="Willemsen">Gonneke Willemsen</name><affiliation wicri:level="3"><nlm:aff id="aff10"><addr-line>Department of Biological Psychology, VU University Amsterdam, Amsterdam, The Netherlands</addr-line></nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Biological Psychology, VU University Amsterdam, Amsterdam</wicri:regionArea><placeName><settlement type="city">Amsterdam</settlement><region nuts="2" type="province">Hollande-Septentrionale</region></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="aff11"><addr-line>The EMGO Institute for Health and Care Research, Amsterdam, The Netherlands</addr-line></nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>The EMGO Institute for Health and Care Research, Amsterdam</wicri:regionArea><placeName><settlement type="city">Amsterdam</settlement><region nuts="2" type="province">Hollande-Septentrionale</region></placeName></affiliation></author><author><name sortKey="Witteman, Jacqueline" sort="Witteman, Jacqueline" uniqKey="Witteman J" first="Jacqueline" last="Witteman">Jacqueline Witteman</name><affiliation wicri:level="3"><nlm:aff id="aff9"><addr-line>Department of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands</addr-line></nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Epidemiology, Erasmus Medical Center, Rotterdam</wicri:regionArea><placeName><settlement type="city">Rotterdam</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="aff26"><addr-line>Netherlands Consortium for Healthy Ageing, Netherlands Genomics Initiative, Leiden, The Netherlands</addr-line></nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Netherlands Consortium for Healthy Ageing, Netherlands Genomics Initiative, Leiden</wicri:regionArea><placeName><settlement type="city">Leyde</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation></author><author><name sortKey="Perola, Markus" sort="Perola, Markus" uniqKey="Perola M" first="Markus" last="Perola">Markus Perola</name><affiliation wicri:level="1"><nlm:aff id="aff4"><addr-line>Estonian Genome Center, University of Tartu, Tartu, Estonia</addr-line></nlm:aff><country xml:lang="fr">Estonie</country><wicri:regionArea>Estonian Genome Center, University of Tartu, Tartu</wicri:regionArea><wicri:noRegion>Tartu</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="aff24"><addr-line>Department of Chronic Disease Prevention, National Institute for Health and Welfare, Helsinki, Finland</addr-line></nlm:aff><country xml:lang="fr">Finlande</country><wicri:regionArea>Department of Chronic Disease Prevention, National Institute for Health and Welfare, Helsinki</wicri:regionArea><wicri:noRegion>Helsinki</wicri:noRegion></affiliation></author><author><name sortKey="Evans, Alun" sort="Evans, Alun" uniqKey="Evans A" first="Alun" last="Evans">Alun Evans</name><affiliation wicri:level="2"><nlm:aff id="aff57"><addr-line>Centre for Public Health, Queen's University of Belfast, Belfast, Northern Ireland</addr-line></nlm:aff><country>Royaume-Uni</country><placeName><region type="country">Irlande du Nord</region></placeName><wicri:cityArea>Centre for Public Health, Queen's University of Belfast, Belfast</wicri:cityArea></affiliation></author><author><name sortKey="Ferrieres, Jean" sort="Ferrieres, Jean" uniqKey="Ferrieres J" first="Jean" last="Ferrières">Jean Ferrières</name><affiliation wicri:level="3"><nlm:aff id="aff58"><addr-line>Department of Cardiology, Toulouse University School of Medicine, Rangueil Hospital, Toulouse, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Department of Cardiology, Toulouse University School of Medicine, Rangueil Hospital, Toulouse</wicri:regionArea><placeName><region type="region">Occitanie (région administrative)</region><region type="old region">Midi-Pyrénées</region><settlement type="city">Toulouse</settlement></placeName></affiliation></author><author><name sortKey="Virtamo, Jarmo" sort="Virtamo, Jarmo" uniqKey="Virtamo J" first="Jarmo" last="Virtamo">Jarmo Virtamo</name><affiliation wicri:level="1"><nlm:aff id="aff24"><addr-line>Department of Chronic Disease Prevention, National Institute for Health and Welfare, Helsinki, Finland</addr-line></nlm:aff><country xml:lang="fr">Finlande</country><wicri:regionArea>Department of Chronic Disease Prevention, National Institute for Health and Welfare, Helsinki</wicri:regionArea><wicri:noRegion>Helsinki</wicri:noRegion></affiliation></author><author><name sortKey="Kee, Frank" sort="Kee, Frank" uniqKey="Kee F" first="Frank" last="Kee">Frank Kee</name><affiliation wicri:level="2"><nlm:aff id="aff59"><addr-line>Centre of Excellence for Public Health Northern Ireland, Queen's University of Belfast, Belfast, Northern Ireland</addr-line></nlm:aff><country>Royaume-Uni</country><placeName><region type="country">Irlande du Nord</region></placeName><wicri:cityArea>Centre of Excellence for Public Health Northern Ireland, Queen's University of Belfast, Belfast</wicri:cityArea></affiliation></author><author><name sortKey="Tregouet, David Alexandre" sort="Tregouet, David Alexandre" uniqKey="Tregouet D" first="David-Alexandre" last="Tregouet">David-Alexandre Tregouet</name><affiliation wicri:level="3"><nlm:aff id="aff60"><addr-line>Institute of Cardiometabolism and Nutrition, INSERM UMR S937, Pierre and Marie Curie University, Paris, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Institute of Cardiometabolism and Nutrition, INSERM UMR S937, Pierre and Marie Curie University, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Arveiler, Dominique" sort="Arveiler, Dominique" uniqKey="Arveiler D" first="Dominique" last="Arveiler">Dominique Arveiler</name><affiliation wicri:level="3"><nlm:aff id="aff61"><addr-line>Department of Epidemiology and Public Health, University of Strasbourg, Strasbourg, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Department of Epidemiology and Public Health, University of Strasbourg, Strasbourg</wicri:regionArea><placeName><region type="region">Grand Est</region><region type="old region">Alsace (région administrative)</region><settlement type="city">Strasbourg</settlement></placeName></affiliation></author><author><name sortKey="Amouyel, Philippe" sort="Amouyel, Philippe" uniqKey="Amouyel P" first="Philippe" last="Amouyel">Philippe Amouyel</name><affiliation wicri:level="3"><nlm:aff id="aff62"><addr-line>Institut Pasteur de Lille, INSERM U744, Université Lille Nord de France, Lille, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Institut Pasteur de Lille, INSERM U744, Université Lille Nord de France, Lille</wicri:regionArea><placeName><region type="region">Hauts-de-France</region><region type="old region">Nord-Pas-de-Calais</region><settlement type="city">Lille</settlement></placeName></affiliation></author><author><name sortKey="Ferrario, Marco M" sort="Ferrario, Marco M" uniqKey="Ferrario M" first="Marco M." last="Ferrario">Marco M. Ferrario</name><affiliation wicri:level="1"><nlm:aff id="aff63"><addr-line>Epidemiology and Preventive Medicine Research Centre, Department of Clinical and Experimental Medicine, University of Insubria, Varese, Italy</addr-line></nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Epidemiology and Preventive Medicine Research Centre, Department of Clinical and Experimental Medicine, University of Insubria, Varese</wicri:regionArea><wicri:noRegion>Varese</wicri:noRegion></affiliation></author><author><name sortKey="Brambilla, Paolo" sort="Brambilla, Paolo" uniqKey="Brambilla P" first="Paolo" last="Brambilla">Paolo Brambilla</name><affiliation wicri:level="1"><nlm:aff id="aff64"><addr-line>Department of Experimental Medicine, University of Milano-Bicocca, Monza, Italy</addr-line></nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Experimental Medicine, University of Milano-Bicocca, Monza</wicri:regionArea><wicri:noRegion>Monza</wicri:noRegion></affiliation></author><author><name sortKey="Hall, Alistair S" sort="Hall, Alistair S" uniqKey="Hall A" first="Alistair S." last="Hall">Alistair S. Hall</name><affiliation wicri:level="4"><nlm:aff id="aff30"><addr-line>Division of Epidemiology, Leeds Institute of Genetics, Health and Therapeutics, School of Medicine, University of Leeds, Leeds, United Kingdom</addr-line></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Division of Epidemiology, Leeds Institute of Genetics, Health and Therapeutics, School of Medicine, University of Leeds, Leeds</wicri:regionArea><orgName type="university">Université de Leeds</orgName><placeName><settlement type="city">Leeds</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Yorkshire-et-Humber</region></placeName></affiliation></author><author><name sortKey="Heath, Andrew C" sort="Heath, Andrew C" uniqKey="Heath A" first="Andrew C." last="Heath">Andrew C. Heath</name><affiliation wicri:level="4"><nlm:aff id="aff65"><addr-line>Washington University School of Medicine, St Louis, Missouri, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Washington University School of Medicine, St Louis, Missouri</wicri:regionArea><placeName><region type="state">Missouri (État)</region><settlement type="city">Saint-Louis (Missouri)</settlement></placeName><orgName type="university">École de médecine (Université Washington de Saint-Louis)</orgName></affiliation></author><author><name sortKey="Madden, Pamela A F" sort="Madden, Pamela A F" uniqKey="Madden P" first="Pamela A. F." last="Madden">Pamela A. F. Madden</name><affiliation wicri:level="4"><nlm:aff id="aff65"><addr-line>Washington University School of Medicine, St Louis, Missouri, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Washington University School of Medicine, St Louis, Missouri</wicri:regionArea><placeName><region type="state">Missouri (État)</region><settlement type="city">Saint-Louis (Missouri)</settlement></placeName><orgName type="university">École de médecine (Université Washington de Saint-Louis)</orgName></affiliation></author><author><name sortKey="Martin, Nicholas G" sort="Martin, Nicholas G" uniqKey="Martin N" first="Nicholas G." last="Martin">Nicholas G. Martin</name><affiliation wicri:level="1"><nlm:aff id="aff17"><addr-line>Queensland Institute of Medical Research, Herston, Australia</addr-line></nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Queensland Institute of Medical Research, Herston</wicri:regionArea><wicri:noRegion>Herston</wicri:noRegion></affiliation></author><author><name sortKey="Montgomery, Grant W" sort="Montgomery, Grant W" uniqKey="Montgomery G" first="Grant W." last="Montgomery">Grant W. Montgomery</name><affiliation wicri:level="1"><nlm:aff id="aff17"><addr-line>Queensland Institute of Medical Research, Herston, Australia</addr-line></nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Queensland Institute of Medical Research, Herston</wicri:regionArea><wicri:noRegion>Herston</wicri:noRegion></affiliation></author><author><name sortKey="Whitfield, John B" sort="Whitfield, John B" uniqKey="Whitfield J" first="John B." last="Whitfield">John B. Whitfield</name><affiliation wicri:level="1"><nlm:aff id="aff17"><addr-line>Queensland Institute of Medical Research, Herston, Australia</addr-line></nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Queensland Institute of Medical Research, Herston</wicri:regionArea><wicri:noRegion>Herston</wicri:noRegion></affiliation></author><author><name sortKey="Jula, Antti" sort="Jula, Antti" uniqKey="Jula A" first="Antti" last="Jula">Antti Jula</name><affiliation wicri:level="3"><nlm:aff id="aff66"><addr-line>Population Studies Unit, Department of Chronic Disease Prevention, National Institute for Health and Welfare, Turku, Finland</addr-line></nlm:aff><country xml:lang="fr">Finlande</country><wicri:regionArea>Population Studies Unit, Department of Chronic Disease Prevention, National Institute for Health and Welfare, Turku</wicri:regionArea><placeName><settlement type="city">Turku</settlement><region type="région" nuts="2">Finlande occidentale</region></placeName></affiliation></author><author><name sortKey="Knekt, Paul" sort="Knekt, Paul" uniqKey="Knekt P" first="Paul" last="Knekt">Paul Knekt</name><affiliation wicri:level="1"><nlm:aff id="aff67"><addr-line>Department of Health, Functional Capacity and Welfare, National Institute for Health and Welfare, Helsinki, Finland</addr-line></nlm:aff><country xml:lang="fr">Finlande</country><wicri:regionArea>Department of Health, Functional Capacity and Welfare, National Institute for Health and Welfare, Helsinki</wicri:regionArea><wicri:noRegion>Helsinki</wicri:noRegion></affiliation></author><author><name sortKey="Oostra, Ben" sort="Oostra, Ben" uniqKey="Oostra B" first="Ben" last="Oostra">Ben Oostra</name><affiliation wicri:level="3"><nlm:aff id="aff68"><addr-line>Department of Clinical Genetics, Erasmus Medical Center, Rotterdam, The Netherlands</addr-line></nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Clinical Genetics, Erasmus Medical Center, Rotterdam</wicri:regionArea><placeName><settlement type="city">Rotterdam</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation></author><author><name sortKey="Van Duijn, Cornelia M" sort="Van Duijn, Cornelia M" uniqKey="Van Duijn C" first="Cornelia M." last="Van Duijn">Cornelia M. Van Duijn</name><affiliation wicri:level="3"><nlm:aff id="aff23"><addr-line>Department of Genetic Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands</addr-line></nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Genetic Epidemiology, Erasmus Medical Center, Rotterdam</wicri:regionArea><placeName><settlement type="city">Rotterdam</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="aff69"><addr-line>Netherlands Genomic Initiative, Leiden, The Netherlands</addr-line></nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Netherlands Genomic Initiative, Leiden</wicri:regionArea><placeName><settlement type="city">Leyde</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="aff70"><addr-line>Centre for Medical Systems Biology, Leiden, The Netherlands</addr-line></nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Centre for Medical Systems Biology, Leiden</wicri:regionArea><placeName><settlement type="city">Leyde</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation></author><author><name sortKey="Penninx, Brenda W J H" sort="Penninx, Brenda W J H" uniqKey="Penninx B" first="Brenda W. J. H." last="Penninx">Brenda W. J. H. Penninx</name><affiliation wicri:level="3"><nlm:aff id="aff11"><addr-line>The EMGO Institute for Health and Care Research, Amsterdam, The Netherlands</addr-line></nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>The EMGO Institute for Health and Care Research, Amsterdam</wicri:regionArea><placeName><settlement type="city">Amsterdam</settlement><region nuts="2" type="province">Hollande-Septentrionale</region></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="aff54"><addr-line>Department of Psychiatry, VU University Medical Center, Amsterdam, The Netherlands</addr-line></nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Psychiatry, VU University Medical Center, Amsterdam</wicri:regionArea><placeName><settlement type="city">Amsterdam</settlement><region nuts="2" type="province">Hollande-Septentrionale</region></placeName></affiliation></author><author><name sortKey="Davey Smith, George" sort="Davey Smith, George" uniqKey="Davey Smith G" first="George" last="Davey Smith">George Davey Smith</name><affiliation wicri:level="1"><nlm:aff id="aff71"><addr-line>MRC Centre for Integrative Epidemiology Unit, University of Bristol, Bristol, United Kingdom</addr-line></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>MRC Centre for Integrative Epidemiology Unit, University of Bristol, Bristol</wicri:regionArea><wicri:noRegion>Bristol</wicri:noRegion></affiliation></author><author><name sortKey="Kaprio, Jaakko" sort="Kaprio, Jaakko" uniqKey="Kaprio J" first="Jaakko" last="Kaprio">Jaakko Kaprio</name><affiliation wicri:level="4"><nlm:aff id="aff6"><addr-line>Institute for Molecular Medicine Finland, University of Helsinki, Helsinki, Finland</addr-line></nlm:aff><country xml:lang="fr">Finlande</country><wicri:regionArea>Institute for Molecular Medicine Finland, University of Helsinki, Helsinki</wicri:regionArea><orgName type="university">Université d'Helsinki</orgName><placeName><settlement type="city">Helsinki</settlement><region type="région" nuts="2">Uusimaa</region></placeName></affiliation><affiliation wicri:level="4"><nlm:aff id="aff35"><addr-line>Department of Public Health, Hjelt Institute, University of Helsinki, Helsinki, Finland</addr-line></nlm:aff><country xml:lang="fr">Finlande</country><wicri:regionArea>Department of Public Health, Hjelt Institute, University of Helsinki, Helsinki</wicri:regionArea><orgName type="university">Université d'Helsinki</orgName><placeName><settlement type="city">Helsinki</settlement><region type="région" nuts="2">Uusimaa</region></placeName></affiliation><affiliation wicri:level="1"><nlm:aff id="aff72"><addr-line>Department of Mental Health and Substance Abuse Services, National Institute for Health and Welfare, Helsinki, Finland</addr-line></nlm:aff><country xml:lang="fr">Finlande</country><wicri:regionArea>Department of Mental Health and Substance Abuse Services, National Institute for Health and Welfare, Helsinki</wicri:regionArea><wicri:noRegion>Helsinki</wicri:noRegion></affiliation></author><author><name sortKey="Samani, Nilesh J" sort="Samani, Nilesh J" uniqKey="Samani N" first="Nilesh J." last="Samani">Nilesh J. Samani</name><affiliation wicri:level="1"><nlm:aff id="aff19"><addr-line>Department of Cardiovascular Sciences, University of Leicester, Leicester, United Kingdom</addr-line></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Cardiovascular Sciences, University of Leicester, Leicester</wicri:regionArea><wicri:noRegion>Leicester</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="aff20"><addr-line>National Institute for Health Research, Leicester Cardiovascular Biomedical Research Unit, Glenfield Hospital, Leicester, United Kingdom</addr-line></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>National Institute for Health Research, Leicester Cardiovascular Biomedical Research Unit, Glenfield Hospital, Leicester</wicri:regionArea><wicri:noRegion>Leicester</wicri:noRegion></affiliation></author><author><name sortKey="Gieger, Christian" sort="Gieger, Christian" uniqKey="Gieger C" first="Christian" last="Gieger">Christian Gieger</name><affiliation wicri:level="1"><nlm:aff id="aff12"><addr-line>Institute of Genetic Epidemiology, Helmholtz Zentrum München—German Research Center for Environmental Health, Neuherberg, Germany</addr-line></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Institute of Genetic Epidemiology, Helmholtz Zentrum München—German Research Center for Environmental Health, Neuherberg</wicri:regionArea><wicri:noRegion>Neuherberg</wicri:noRegion><wicri:noRegion>Neuherberg</wicri:noRegion><wicri:noRegion>Neuherberg</wicri:noRegion></affiliation></author><author><name sortKey="Peters, Annette" sort="Peters, Annette" uniqKey="Peters A" first="Annette" last="Peters">Annette Peters</name><affiliation wicri:level="1"><nlm:aff id="aff32"><addr-line>Institute of Epidemiology II, Helmholtz Zentrum München—German Research Center for Environmental Health, Neuherberg, Germany</addr-line></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Institute of Epidemiology II, Helmholtz Zentrum München—German Research Center for Environmental Health, Neuherberg</wicri:regionArea><wicri:noRegion>Neuherberg</wicri:noRegion><wicri:noRegion>Neuherberg</wicri:noRegion><wicri:noRegion>Neuherberg</wicri:noRegion></affiliation><affiliation wicri:level="3"><nlm:aff id="aff73"><addr-line>Munich Heart Alliance, Munich, Germany</addr-line></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Munich Heart Alliance, Munich</wicri:regionArea><placeName><region type="land" nuts="1">Bavière</region><region type="district" nuts="2">District de Haute-Bavière</region><settlement type="city">Munich</settlement></placeName></affiliation></author><author><name sortKey="Wichmann, H Erich" sort="Wichmann, H Erich" uniqKey="Wichmann H" first="H.-Erich" last="Wichmann">H.-Erich Wichmann</name><affiliation wicri:level="1"><nlm:aff id="aff31"><addr-line>Institute of Epidemiology I, Helmholtz Zentrum München—German Research Center for Environmental Health, Neuherberg, Germany</addr-line></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Institute of Epidemiology I, Helmholtz Zentrum München—German Research Center for Environmental Health, Neuherberg</wicri:regionArea><wicri:noRegion>Neuherberg</wicri:noRegion><wicri:noRegion>Neuherberg</wicri:noRegion><wicri:noRegion>Neuherberg</wicri:noRegion></affiliation><affiliation wicri:level="3"><nlm:aff id="aff74"><addr-line>Institute of Medical Informatics, Biometry and Epidemiology, Chair of Epidemiology, Ludwig-Maximilians-Universität, Munich, Germany</addr-line></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Institute of Medical Informatics, Biometry and Epidemiology, Chair of Epidemiology, Ludwig-Maximilians-Universität, Munich</wicri:regionArea><placeName><region type="land" nuts="1">Bavière</region><region type="district" nuts="2">District de Haute-Bavière</region><settlement type="city">Munich</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="aff75"><addr-line>Klinikum Grosshadern, Munich, Germany</addr-line></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Klinikum Grosshadern, Munich</wicri:regionArea><placeName><region type="land" nuts="1">Bavière</region><region type="district" nuts="2">District de Haute-Bavière</region><settlement type="city">Munich</settlement></placeName></affiliation></author><author><name sortKey="Boomsma, Dorret I" sort="Boomsma, Dorret I" uniqKey="Boomsma D" first="Dorret I." last="Boomsma">Dorret I. Boomsma</name><affiliation wicri:level="3"><nlm:aff id="aff10"><addr-line>Department of Biological Psychology, VU University Amsterdam, Amsterdam, The Netherlands</addr-line></nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Biological Psychology, VU University Amsterdam, Amsterdam</wicri:regionArea><placeName><settlement type="city">Amsterdam</settlement><region nuts="2" type="province">Hollande-Septentrionale</region></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="aff11"><addr-line>The EMGO Institute for Health and Care Research, Amsterdam, The Netherlands</addr-line></nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>The EMGO Institute for Health and Care Research, Amsterdam</wicri:regionArea><placeName><settlement type="city">Amsterdam</settlement><region nuts="2" type="province">Hollande-Septentrionale</region></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="aff53"><addr-line>Neuroscience Campus Amsterdam, Amsterdam, The Netherlands</addr-line></nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Neuroscience Campus Amsterdam, Amsterdam</wicri:regionArea><placeName><settlement type="city">Amsterdam</settlement><region nuts="2" type="province">Hollande-Septentrionale</region></placeName></affiliation></author><author><name sortKey="De Geus, Eco J C" sort="De Geus, Eco J C" uniqKey="De Geus E" first="Eco J. C." last="De Geus">Eco J. C. De Geus</name><affiliation wicri:level="3"><nlm:aff id="aff10"><addr-line>Department of Biological Psychology, VU University Amsterdam, Amsterdam, The Netherlands</addr-line></nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Biological Psychology, VU University Amsterdam, Amsterdam</wicri:regionArea><placeName><settlement type="city">Amsterdam</settlement><region nuts="2" type="province">Hollande-Septentrionale</region></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="aff11"><addr-line>The EMGO Institute for Health and Care Research, Amsterdam, The Netherlands</addr-line></nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>The EMGO Institute for Health and Care Research, Amsterdam</wicri:regionArea><placeName><settlement type="city">Amsterdam</settlement><region nuts="2" type="province">Hollande-Septentrionale</region></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="aff53"><addr-line>Neuroscience Campus Amsterdam, Amsterdam, The Netherlands</addr-line></nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Neuroscience Campus Amsterdam, Amsterdam</wicri:regionArea><placeName><settlement type="city">Amsterdam</settlement><region nuts="2" type="province">Hollande-Septentrionale</region></placeName></affiliation></author><author><name sortKey="Tuomi, Tiinamaija" sort="Tuomi, Tiinamaija" uniqKey="Tuomi T" first="Tiinamaija" last="Tuomi">Tiinamaija Tuomi</name><affiliation wicri:level="1"><nlm:aff id="aff42"><addr-line>Folkhälsan Research Centre, Helsinki, Finland</addr-line></nlm:aff><country xml:lang="fr">Finlande</country><wicri:regionArea>Folkhälsan Research Centre, Helsinki</wicri:regionArea><wicri:noRegion>Helsinki</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="aff76"><addr-line>Department of Medicine, Helsinki University Central Hospital, Helsinki, Finland</addr-line></nlm:aff><country xml:lang="fr">Finlande</country><wicri:regionArea>Department of Medicine, Helsinki University Central Hospital, Helsinki</wicri:regionArea><wicri:noRegion>Helsinki</wicri:noRegion></affiliation></author><author><name sortKey="Power, Chris" sort="Power, Chris" uniqKey="Power C" first="Chris" last="Power">Chris Power</name><affiliation wicri:level="3"><nlm:aff id="aff38"><addr-line>Centre for Paediatric Epidemiology and Biostatistics and Medical Research Council Centre for the Epidemiology of Child Health, University College London Institute of Child Health, London, United Kingdom</addr-line></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Centre for Paediatric Epidemiology and Biostatistics and Medical Research Council Centre for the Epidemiology of Child Health, University College London Institute of Child Health, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Hammond, Christopher J" sort="Hammond, Christopher J" uniqKey="Hammond C" first="Christopher J." last="Hammond">Christopher J. Hammond</name><affiliation wicri:level="1"><nlm:aff id="aff15"><addr-line>Department of Twin Research and Genetic Epidemiology, King's College London, United Kingdom</addr-line></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Twin Research and Genetic Epidemiology, King's College London</wicri:regionArea><wicri:noRegion>King's College London</wicri:noRegion></affiliation></author><author><name sortKey="Spector, Tim D" sort="Spector, Tim D" uniqKey="Spector T" first="Tim D." last="Spector">Tim D. Spector</name><affiliation wicri:level="1"><nlm:aff id="aff15"><addr-line>Department of Twin Research and Genetic Epidemiology, King's College London, United Kingdom</addr-line></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Twin Research and Genetic Epidemiology, King's College London</wicri:regionArea><wicri:noRegion>King's College London</wicri:noRegion></affiliation></author><author><name sortKey="Lind, Lars" sort="Lind, Lars" uniqKey="Lind L" first="Lars" last="Lind">Lars Lind</name><affiliation wicri:level="4"><nlm:aff id="aff77"><addr-line>Department of Medical Sciences, Uppsala University, Uppsala, Sweden</addr-line></nlm:aff><country xml:lang="fr">Suède</country><wicri:regionArea>Department of Medical Sciences, Uppsala University, Uppsala</wicri:regionArea><orgName type="university">Université d'Uppsala</orgName><placeName><settlement type="city">Uppsala</settlement><region nuts="1">Svealand</region><region nuts="1">East Middle Sweden</region></placeName></affiliation></author><author><name sortKey="Orho Melander, Marju" sort="Orho Melander, Marju" uniqKey="Orho Melander M" first="Marju" last="Orho-Melander">Marju Orho-Melander</name><affiliation wicri:level="1"><nlm:aff id="aff8"><addr-line>Department of Clinical Sciences, Diabetes and Endocrinology, Lund University Diabetes Centre, Lund University and Skåne University Hospital, Malmö, Sweden</addr-line></nlm:aff><country xml:lang="fr">Suède</country><wicri:regionArea>Department of Clinical Sciences, Diabetes and Endocrinology, Lund University Diabetes Centre, Lund University and Skåne University Hospital, Malmö</wicri:regionArea><wicri:noRegion>Malmö</wicri:noRegion></affiliation></author><author><name sortKey="Palmer, Colin Neil Alexander" sort="Palmer, Colin Neil Alexander" uniqKey="Palmer C" first="Colin Neil Alexander" last="Palmer">Colin Neil Alexander Palmer</name><affiliation wicri:level="1"><nlm:aff id="aff13"><addr-line>Medical Research Institute, Ninewells Hospital and Medical School, University of Dundee, Dundee, United Kingdom</addr-line></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Medical Research Institute, Ninewells Hospital and Medical School, University of Dundee, Dundee</wicri:regionArea><wicri:noRegion>Dundee</wicri:noRegion></affiliation></author><author><name sortKey="Morris, Andrew D" sort="Morris, Andrew D" uniqKey="Morris A" first="Andrew D." last="Morris">Andrew D. Morris</name><affiliation wicri:level="1"><nlm:aff id="aff13"><addr-line>Medical Research Institute, Ninewells Hospital and Medical School, University of Dundee, Dundee, United Kingdom</addr-line></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Medical Research Institute, Ninewells Hospital and Medical School, University of Dundee, Dundee</wicri:regionArea><wicri:noRegion>Dundee</wicri:noRegion></affiliation></author><author><name sortKey="Groop, Leif" sort="Groop, Leif" uniqKey="Groop L" first="Leif" last="Groop">Leif Groop</name><affiliation wicri:level="4"><nlm:aff id="aff6"><addr-line>Institute for Molecular Medicine Finland, University of Helsinki, Helsinki, Finland</addr-line></nlm:aff><country xml:lang="fr">Finlande</country><wicri:regionArea>Institute for Molecular Medicine Finland, University of Helsinki, Helsinki</wicri:regionArea><orgName type="university">Université d'Helsinki</orgName><placeName><settlement type="city">Helsinki</settlement><region type="région" nuts="2">Uusimaa</region></placeName></affiliation><affiliation wicri:level="1"><nlm:aff id="aff8"><addr-line>Department of Clinical Sciences, Diabetes and Endocrinology, Lund University Diabetes Centre, Lund University and Skåne University Hospital, Malmö, Sweden</addr-line></nlm:aff><country xml:lang="fr">Suède</country><wicri:regionArea>Department of Clinical Sciences, Diabetes and Endocrinology, Lund University Diabetes Centre, Lund University and Skåne University Hospital, Malmö</wicri:regionArea><wicri:noRegion>Malmö</wicri:noRegion></affiliation></author><author><name sortKey="J Rvelin, Marjo Riitta" sort="J Rvelin, Marjo Riitta" uniqKey="J Rvelin M" first="Marjo-Riitta" last="J Rvelin">Marjo-Riitta J Rvelin</name><affiliation wicri:level="1"><nlm:aff id="aff14"><addr-line>Institute of Health Sciences, University of Oulu, Oulu, Finland</addr-line></nlm:aff><country xml:lang="fr">Finlande</country><wicri:regionArea>Institute of Health Sciences, University of Oulu, Oulu</wicri:regionArea><wicri:noRegion>Oulu</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="aff27"><addr-line>Biocenter Oulu, University of Oulu, Oulu, Finland</addr-line></nlm:aff><country xml:lang="fr">Finlande</country><wicri:regionArea>Biocenter Oulu, University of Oulu, Oulu</wicri:regionArea><wicri:noRegion>Oulu</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="aff48"><addr-line>Department of Children, Young People and Families, National Institute for Health and Welfare, Oulu, Finland</addr-line></nlm:aff><country xml:lang="fr">Finlande</country><wicri:regionArea>Department of Children, Young People and Families, National Institute for Health and Welfare, Oulu</wicri:regionArea><wicri:noRegion>Oulu</wicri:noRegion></affiliation><affiliation wicri:level="3"><nlm:aff id="aff78"><addr-line>Department of Epidemiology and Biostatistics, Imperial College London, London, United Kingdom</addr-line></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Epidemiology and Biostatistics, Imperial College London, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Salomaa, Veikko" sort="Salomaa, Veikko" uniqKey="Salomaa V" first="Veikko" last="Salomaa">Veikko Salomaa</name><affiliation wicri:level="1"><nlm:aff id="aff24"><addr-line>Department of Chronic Disease Prevention, National Institute for Health and Welfare, Helsinki, Finland</addr-line></nlm:aff><country xml:lang="fr">Finlande</country><wicri:regionArea>Department of Chronic Disease Prevention, National Institute for Health and Welfare, Helsinki</wicri:regionArea><wicri:noRegion>Helsinki</wicri:noRegion></affiliation></author><author><name sortKey="Vartiainen, Erkki" sort="Vartiainen, Erkki" uniqKey="Vartiainen E" first="Erkki" last="Vartiainen">Erkki Vartiainen</name><affiliation wicri:level="1"><nlm:aff id="aff79"><addr-line>Division of Welfare and Health Promotion, National Institute for Health and Welfare, Helsinki, Finland</addr-line></nlm:aff><country xml:lang="fr">Finlande</country><wicri:regionArea>Division of Welfare and Health Promotion, National Institute for Health and Welfare, Helsinki</wicri:regionArea><wicri:noRegion>Helsinki</wicri:noRegion></affiliation></author><author><name sortKey="Hofman, Albert" sort="Hofman, Albert" uniqKey="Hofman A" first="Albert" last="Hofman">Albert Hofman</name><affiliation wicri:level="3"><nlm:aff id="aff9"><addr-line>Department of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands</addr-line></nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Epidemiology, Erasmus Medical Center, Rotterdam</wicri:regionArea><placeName><settlement type="city">Rotterdam</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="aff26"><addr-line>Netherlands Consortium for Healthy Ageing, Netherlands Genomics Initiative, Leiden, The Netherlands</addr-line></nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Netherlands Consortium for Healthy Ageing, Netherlands Genomics Initiative, Leiden</wicri:regionArea><placeName><settlement type="city">Leyde</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation></author><author><name sortKey="Ripatti, Samuli" sort="Ripatti, Samuli" uniqKey="Ripatti S" first="Samuli" last="Ripatti">Samuli Ripatti</name><affiliation wicri:level="4"><nlm:aff id="aff6"><addr-line>Institute for Molecular Medicine Finland, University of Helsinki, Helsinki, Finland</addr-line></nlm:aff><country xml:lang="fr">Finlande</country><wicri:regionArea>Institute for Molecular Medicine Finland, University of Helsinki, Helsinki</wicri:regionArea><orgName type="university">Université d'Helsinki</orgName><placeName><settlement type="city">Helsinki</settlement><region type="région" nuts="2">Uusimaa</region></placeName></affiliation><affiliation wicri:level="1"><nlm:aff id="aff24"><addr-line>Department of Chronic Disease Prevention, National Institute for Health and Welfare, Helsinki, Finland</addr-line></nlm:aff><country xml:lang="fr">Finlande</country><wicri:regionArea>Department of Chronic Disease Prevention, National Institute for Health and Welfare, Helsinki</wicri:regionArea><wicri:noRegion>Helsinki</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="aff47"><addr-line>Wellcome Trust Sanger Institute, Hinxton, United Kingdom</addr-line></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Wellcome Trust Sanger Institute, Hinxton</wicri:regionArea><wicri:noRegion>Hinxton</wicri:noRegion></affiliation></author><author><name sortKey="Metspalu, Andres" sort="Metspalu, Andres" uniqKey="Metspalu A" first="Andres" last="Metspalu">Andres Metspalu</name><affiliation wicri:level="1"><nlm:aff id="aff4"><addr-line>Estonian Genome Center, University of Tartu, Tartu, Estonia</addr-line></nlm:aff><country xml:lang="fr">Estonie</country><wicri:regionArea>Estonian Genome Center, University of Tartu, Tartu</wicri:regionArea><wicri:noRegion>Tartu</wicri:noRegion></affiliation></author><author><name sortKey="Thorsteinsdottir, Unnur" sort="Thorsteinsdottir, Unnur" uniqKey="Thorsteinsdottir U" first="Unnur" last="Thorsteinsdottir">Unnur Thorsteinsdottir</name><affiliation wicri:level="1"><nlm:aff id="aff7"><addr-line>deCODE Genetics, Reykjavik, Iceland</addr-line></nlm:aff><country xml:lang="fr">Islande</country><wicri:regionArea>deCODE Genetics, Reykjavik</wicri:regionArea><wicri:noRegion>Reykjavik</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="aff80"><addr-line>Faculty of Medicine, University of Iceland, Reykjavík, Iceland</addr-line></nlm:aff><country xml:lang="fr">Islande</country><wicri:regionArea>Faculty of Medicine, University of Iceland, Reykjavík</wicri:regionArea><wicri:noRegion>Reykjavík</wicri:noRegion></affiliation></author><author><name sortKey="Stefansson, Kari" sort="Stefansson, Kari" uniqKey="Stefansson K" first="Kari" last="Stefansson">Kari Stefansson</name><affiliation wicri:level="1"><nlm:aff id="aff7"><addr-line>deCODE Genetics, Reykjavik, Iceland</addr-line></nlm:aff><country xml:lang="fr">Islande</country><wicri:regionArea>deCODE Genetics, Reykjavik</wicri:regionArea><wicri:noRegion>Reykjavik</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="aff80"><addr-line>Faculty of Medicine, University of Iceland, Reykjavík, Iceland</addr-line></nlm:aff><country xml:lang="fr">Islande</country><wicri:regionArea>Faculty of Medicine, University of Iceland, Reykjavík</wicri:regionArea><wicri:noRegion>Reykjavík</wicri:noRegion></affiliation></author><author><name sortKey="Pedersen, Nancy L" sort="Pedersen, Nancy L" uniqKey="Pedersen N" first="Nancy L." last="Pedersen">Nancy L. Pedersen</name><affiliation wicri:level="3"><nlm:aff id="aff2"><addr-line>Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden</addr-line></nlm:aff><country xml:lang="fr">Suède</country><wicri:regionArea>Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm</wicri:regionArea><placeName><settlement type="city">Stockholm</settlement><region nuts="2">Svealand</region></placeName></affiliation></author><author><name sortKey="Mccarthy, Mark I" sort="Mccarthy, Mark I" uniqKey="Mccarthy M" first="Mark I." last="Mccarthy">Mark I. Mccarthy</name><affiliation wicri:level="4"><nlm:aff id="aff3"><addr-line>Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom</addr-line></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford</wicri:regionArea><placeName><settlement type="city">Oxford</settlement><region type="country">Angleterre</region><region type="comté" nuts="2">Oxfordshire</region><settlement type="city">Oxford</settlement></placeName><orgName type="university">Université d'Oxford</orgName></affiliation><affiliation wicri:level="4"><nlm:aff id="aff5"><addr-line>Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Oxford, United Kingdom</addr-line></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Oxford</wicri:regionArea><placeName><settlement type="city">Oxford</settlement><region type="country">Angleterre</region><region type="comté" nuts="2">Oxfordshire</region><settlement type="city">Oxford</settlement></placeName><orgName type="university">Université d'Oxford</orgName></affiliation><affiliation wicri:level="3"><nlm:aff id="aff81"><addr-line>Oxford National Institute for Health Research Biomedical Research Centre, Churchill Hospital, Oxford, United Kingdom</addr-line></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Oxford National Institute for Health Research Biomedical Research Centre, Churchill Hospital, Oxford</wicri:regionArea><placeName><settlement type="city">Oxford</settlement><region type="country">Angleterre</region><region type="comté" nuts="2">Oxfordshire</region></placeName></affiliation></author><author><name sortKey="Ingelsson, Erik" sort="Ingelsson, Erik" uniqKey="Ingelsson E" first="Erik" last="Ingelsson">Erik Ingelsson</name><affiliation wicri:level="4"><nlm:aff id="aff1"><addr-line>Molecular Epidemiology and Science for Life Laboratory, Department of Medical Sciences, Uppsala University, Uppsala, Sweden</addr-line></nlm:aff><country xml:lang="fr">Suède</country><wicri:regionArea>Molecular Epidemiology and Science for Life Laboratory, Department of Medical Sciences, Uppsala University, Uppsala</wicri:regionArea><orgName type="university">Université d'Uppsala</orgName><placeName><settlement type="city">Uppsala</settlement><region nuts="1">Svealand</region><region nuts="1">East Middle Sweden</region></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="aff2"><addr-line>Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden</addr-line></nlm:aff><country xml:lang="fr">Suède</country><wicri:regionArea>Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm</wicri:regionArea><placeName><settlement type="city">Stockholm</settlement><region nuts="2">Svealand</region></placeName></affiliation><affiliation wicri:level="4"><nlm:aff id="aff3"><addr-line>Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom</addr-line></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford</wicri:regionArea><placeName><settlement type="city">Oxford</settlement><region type="country">Angleterre</region><region type="comté" nuts="2">Oxfordshire</region><settlement type="city">Oxford</settlement></placeName><orgName type="university">Université d'Oxford</orgName></affiliation></author><author><name sortKey="Prokopenko, Inga" sort="Prokopenko, Inga" uniqKey="Prokopenko I" first="Inga" last="Prokopenko">Inga Prokopenko</name><affiliation wicri:level="4"><nlm:aff id="aff3"><addr-line>Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom</addr-line></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford</wicri:regionArea><placeName><settlement type="city">Oxford</settlement><region type="country">Angleterre</region><region type="comté" nuts="2">Oxfordshire</region><settlement type="city">Oxford</settlement></placeName><orgName type="university">Université d'Oxford</orgName></affiliation><affiliation wicri:level="4"><nlm:aff id="aff5"><addr-line>Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Oxford, United Kingdom</addr-line></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Oxford</wicri:regionArea><placeName><settlement type="city">Oxford</settlement><region type="country">Angleterre</region><region type="comté" nuts="2">Oxfordshire</region><settlement type="city">Oxford</settlement></placeName><orgName type="university">Université d'Oxford</orgName></affiliation><affiliation wicri:level="3"><nlm:aff id="aff82"><addr-line>Department of Genomics of Common Disease, School of Public Health, Imperial College London, London, United Kingdom</addr-line></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Genomics of Common Disease, School of Public Health, Imperial College London, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author></analytic><series><title level="j">PLoS Medicine</title><idno type="ISSN">1549-1277</idno><idno type="eISSN">1549-1676</idno><imprint><date when="2013">2013</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>In this study, Prokopenko and colleagues provide novel evidence for causal relationship between adiposity and heart failure and increased liver enzymes using a Mendelian randomization study design.</p><p><italic>Please see later in the article for the Editors' Summary</italic></p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Gersh, Bj" uniqKey="Gersh B">BJ Gersh</name></author><author><name sortKey="Sliwa, K" uniqKey="Sliwa K">K Sliwa</name></author><author><name sortKey="Mayosi, Bm" uniqKey="Mayosi B">BM Mayosi</name></author><author><name sortKey="Yusuf, S" uniqKey="Yusuf S">S Yusuf</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Whitlock, G" uniqKey="Whitlock G">G Whitlock</name></author><author><name sortKey="Lewington, S" uniqKey="Lewington S">S Lewington</name></author><author><name sortKey="Sherliker, P" uniqKey="Sherliker P">P Sherliker</name></author><author><name sortKey="Clarke, R" uniqKey="Clarke R">R 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Cecil</name></author><author><name sortKey="Tavendale, R" uniqKey="Tavendale R">R Tavendale</name></author><author><name sortKey="Watt, P" uniqKey="Watt P">P Watt</name></author><author><name sortKey="Hetherington, Mm" uniqKey="Hetherington M">MM Hetherington</name></author><author><name sortKey="Palmer, Cn" uniqKey="Palmer C">CN Palmer</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Palmer, Tm" uniqKey="Palmer T">TM Palmer</name></author><author><name sortKey="Lawlor, Da" uniqKey="Lawlor D">DA Lawlor</name></author><author><name sortKey="Harbord, Rm" uniqKey="Harbord R">RM Harbord</name></author><author><name sortKey="Sheehan, Na" uniqKey="Sheehan N">NA Sheehan</name></author><author><name sortKey="Tobias, Jh" uniqKey="Tobias J">JH Tobias</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Willer, Cj" uniqKey="Willer C">CJ Willer</name></author><author><name sortKey="Speliotes, Ek" uniqKey="Speliotes E">EK Speliotes</name></author><author><name sortKey="Loos, Rj" uniqKey="Loos R">RJ Loos</name></author><author><name sortKey="Li, S" uniqKey="Li S">S Li</name></author><author><name sortKey="Lindgren, Cm" uniqKey="Lindgren C">CM Lindgren</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Frayling, Tm" uniqKey="Frayling T">TM Frayling</name></author><author><name sortKey="Timpson, Nj" uniqKey="Timpson N">NJ Timpson</name></author><author><name sortKey="Weedon, Mn" uniqKey="Weedon M">MN Weedon</name></author><author><name sortKey="Zeggini, E" uniqKey="Zeggini E">E Zeggini</name></author><author><name sortKey="Freathy, Rm" uniqKey="Freathy R">RM Freathy</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list><country><li>Allemagne</li><li>Australie</li><li>Danemark</li><li>Estonie</li><li>Finlande</li><li>France</li><li>Islande</li><li>Italie</li><li>Pays-Bas</li><li>Royaume-Uni</li><li>Suède</li><li>États-Unis</li></country><region><li>Alsace (région administrative)</li><li>Angleterre</li><li>Bade-Wurtemberg</li><li>Basse-Saxe</li><li>Bavière</li><li>District de Düsseldorf</li><li>District de Haute-Bavière</li><li>District de Tübingen</li><li>East Middle Sweden</li><li>Finlande occidentale</li><li>Grand Est</li><li>Grand Londres</li><li>Hauts-de-France</li><li>Hollande-Méridionale</li><li>Hollande-Septentrionale</li><li>Irlande du Nord</li><li>Lombardie</li><li>Midi-Pyrénées</li><li>Missouri (État)</li><li>Nord-Pas-de-Calais</li><li>Occitanie (région administrative)</li><li>Oxfordshire</li><li>Rhénanie-du-Nord-Westphalie</li><li>Svealand</li><li>Uusimaa</li><li>Yorkshire-et-Humber</li><li>Île-de-France</li></region><settlement><li>Amsterdam</li><li>Düsseldorf</li><li>Hanovre</li><li>Helsinki</li><li>Leeds</li><li>Leyde</li><li>Lille</li><li>Londres</li><li>Milan</li><li>Munich</li><li>Oxford</li><li>Paris</li><li>Rotterdam</li><li>Saint-Louis (Missouri)</li><li>Stockholm</li><li>Strasbourg</li><li>Toulouse</li><li>Turku</li><li>Ulm</li><li>Uppsala</li></settlement><orgName><li>Université d'Helsinki</li><li>Université d'Oxford</li><li>Université d'Uppsala</li><li>Université de Leeds</li><li>École de médecine (Université Washington de Saint-Louis)</li></orgName></list><tree><country name="Suède"><region name="Svealand"><name sortKey="Fall, Tove" sort="Fall, Tove" uniqKey="Fall T" first="Tove" last="Fall">Tove Fall</name></region><name sortKey="Fall, Tove" sort="Fall, Tove" uniqKey="Fall T" first="Tove" last="Fall">Tove Fall</name><name sortKey="Groop, Leif" sort="Groop, Leif" uniqKey="Groop L" first="Leif" last="Groop">Leif Groop</name><name sortKey="H Gg, Sara" sort="H Gg, Sara" uniqKey="H Gg S" first="Sara" last="H Gg">Sara H Gg</name><name sortKey="H Gg, Sara" sort="H Gg, Sara" uniqKey="H Gg S" first="Sara" last="H Gg">Sara H Gg</name><name sortKey="Ingelsson, Erik" sort="Ingelsson, Erik" uniqKey="Ingelsson E" first="Erik" last="Ingelsson">Erik Ingelsson</name><name sortKey="Ingelsson, Erik" sort="Ingelsson, Erik" uniqKey="Ingelsson E" first="Erik" last="Ingelsson">Erik Ingelsson</name><name sortKey="Ladenvall, Claes" sort="Ladenvall, Claes" uniqKey="Ladenvall C" first="Claes" last="Ladenvall">Claes Ladenvall</name><name sortKey="Lind, Lars" sort="Lind, Lars" uniqKey="Lind L" first="Lars" last="Lind">Lars Lind</name><name sortKey="Lyssenko, Valeriya" sort="Lyssenko, Valeriya" uniqKey="Lyssenko V" first="Valeriya" last="Lyssenko">Valeriya Lyssenko</name><name sortKey="Orho Melander, Marju" 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Braund</name><name sortKey="Davey Smith, George" sort="Davey Smith, George" uniqKey="Davey Smith G" first="George" last="Davey Smith">George Davey Smith</name><name sortKey="Doney, Alexander S F" sort="Doney, Alexander S F" uniqKey="Doney A" first="Alexander S. F." last="Doney">Alexander S. F. Doney</name><name sortKey="Donnelly, Louise A" sort="Donnelly, Louise A" uniqKey="Donnelly L" first="Louise A." last="Donnelly">Louise A. Donnelly</name><name sortKey="Elliott, Paul" sort="Elliott, Paul" uniqKey="Elliott P" first="Paul" last="Elliott">Paul Elliott</name><name sortKey="Evans, Alun" sort="Evans, Alun" uniqKey="Evans A" first="Alun" last="Evans">Alun Evans</name><name sortKey="Hall, Alistair S" sort="Hall, Alistair S" uniqKey="Hall A" first="Alistair S." last="Hall">Alistair S. Hall</name><name sortKey="Hammond, Christopher J" sort="Hammond, Christopher J" uniqKey="Hammond C" first="Christopher J." last="Hammond">Christopher J. Hammond</name><name sortKey="Horikoshi, Momoko" sort="Horikoshi, Momoko" uniqKey="Horikoshi M" first="Momoko" last="Horikoshi">Momoko Horikoshi</name><name sortKey="Horikoshi, Momoko" sort="Horikoshi, Momoko" uniqKey="Horikoshi M" first="Momoko" last="Horikoshi">Momoko Horikoshi</name><name sortKey="Hypponen, Elina" sort="Hypponen, Elina" uniqKey="Hypponen E" first="Elina" last="Hyppönen">Elina Hyppönen</name><name sortKey="Ingelsson, Erik" sort="Ingelsson, Erik" uniqKey="Ingelsson E" first="Erik" last="Ingelsson">Erik Ingelsson</name><name sortKey="J Rvelin, Marjo Riitta" sort="J Rvelin, Marjo Riitta" uniqKey="J Rvelin M" first="Marjo-Riitta" last="J Rvelin">Marjo-Riitta J Rvelin</name><name sortKey="Kee, Frank" sort="Kee, Frank" uniqKey="Kee F" first="Frank" last="Kee">Frank Kee</name><name sortKey="Lindgren, Cecilia" sort="Lindgren, Cecilia" uniqKey="Lindgren C" first="Cecilia" last="Lindgren">Cecilia Lindgren</name><name sortKey="Mangino, Massimo" sort="Mangino, Massimo" uniqKey="Mangino M" first="Massimo" last="Mangino">Massimo Mangino</name><name sortKey="Mccarthy, Mark I" sort="Mccarthy, Mark I" uniqKey="Mccarthy M" first="Mark I." last="Mccarthy">Mark I. Mccarthy</name><name sortKey="Mccarthy, Mark I" sort="Mccarthy, Mark I" uniqKey="Mccarthy M" first="Mark I." last="Mccarthy">Mark I. Mccarthy</name><name sortKey="Mccarthy, Mark I" sort="Mccarthy, Mark I" uniqKey="Mccarthy M" first="Mark I." last="Mccarthy">Mark I. Mccarthy</name><name sortKey="Morris, Andrew D" sort="Morris, Andrew D" uniqKey="Morris A" first="Andrew D." last="Morris">Andrew D. Morris</name><name sortKey="Nelson, Christopher P" sort="Nelson, Christopher P" uniqKey="Nelson C" first="Christopher P." last="Nelson">Christopher P. Nelson</name><name sortKey="Nelson, Christopher P" sort="Nelson, Christopher P" uniqKey="Nelson C" first="Christopher P." last="Nelson">Christopher P. Nelson</name><name sortKey="Palmer, Colin Neil Alexander" sort="Palmer, Colin Neil Alexander" uniqKey="Palmer C" first="Colin Neil Alexander" last="Palmer">Colin Neil Alexander Palmer</name><name sortKey="Power, Chris" sort="Power, Chris" uniqKey="Power C" first="Chris" last="Power">Chris Power</name><name sortKey="Prokopenko, Inga" sort="Prokopenko, Inga" uniqKey="Prokopenko I" first="Inga" last="Prokopenko">Inga Prokopenko</name><name sortKey="Prokopenko, Inga" sort="Prokopenko, Inga" uniqKey="Prokopenko I" first="Inga" last="Prokopenko">Inga Prokopenko</name><name sortKey="Prokopenko, Inga" sort="Prokopenko, Inga" uniqKey="Prokopenko I" first="Inga" last="Prokopenko">Inga Prokopenko</name><name sortKey="Rayner, Nigel W" sort="Rayner, Nigel W" uniqKey="Rayner N" first="Nigel W." last="Rayner">Nigel W. Rayner</name><name sortKey="Rayner, Nigel W" sort="Rayner, Nigel W" uniqKey="Rayner N" first="Nigel W." last="Rayner">Nigel W. Rayner</name><name sortKey="Rayner, Nigel W" sort="Rayner, Nigel W" uniqKey="Rayner N" first="Nigel W." last="Rayner">Nigel W. Rayner</name><name sortKey="Ripatti, Samuli" sort="Ripatti, Samuli" uniqKey="Ripatti S" first="Samuli" last="Ripatti">Samuli Ripatti</name><name sortKey="Robertson, Neil" sort="Robertson, Neil" uniqKey="Robertson N" first="Neil" last="Robertson">Neil Robertson</name><name sortKey="Robertson, Neil" sort="Robertson, Neil" uniqKey="Robertson N" first="Neil" last="Robertson">Neil Robertson</name><name sortKey="Samani, Nilesh J" sort="Samani, Nilesh J" uniqKey="Samani N" first="Nilesh J." last="Samani">Nilesh J. Samani</name><name sortKey="Samani, Nilesh J" sort="Samani, Nilesh J" uniqKey="Samani N" first="Nilesh J." last="Samani">Nilesh J. Samani</name><name sortKey="Small, Kerrin S" sort="Small, Kerrin S" uniqKey="Small K" first="Kerrin S." last="Small">Kerrin S. Small</name><name sortKey="Spector, Tim D" sort="Spector, Tim D" uniqKey="Spector T" first="Tim D." last="Spector">Tim D. Spector</name><name sortKey="Tobin, Martin D" sort="Tobin, Martin D" uniqKey="Tobin M" first="Martin D." last="Tobin">Martin D. Tobin</name><name sortKey="Van Zuydam, Natalie R" sort="Van Zuydam, Natalie R" uniqKey="Van Zuydam N" first="Natalie R." last="Van Zuydam">Natalie R. Van Zuydam</name></country><country name="Estonie"><noRegion><name sortKey="M Gi, Reedik" sort="M Gi, Reedik" uniqKey="M Gi R" first="Reedik" last="M Gi">Reedik M Gi</name></noRegion><name sortKey="Esko, T Nu" sort="Esko, T Nu" uniqKey="Esko T" first="T Nu" last="Esko">T Nu Esko</name><name sortKey="Fischer, Krista" sort="Fischer, Krista" uniqKey="Fischer K" first="Krista" last="Fischer">Krista Fischer</name><name sortKey="Kals, Mart" sort="Kals, Mart" uniqKey="Kals M" first="Mart" last="Kals">Mart Kals</name><name sortKey="Metspalu, Andres" sort="Metspalu, Andres" uniqKey="Metspalu A" first="Andres" last="Metspalu">Andres Metspalu</name><name sortKey="Perola, Markus" sort="Perola, Markus" uniqKey="Perola M" first="Markus" last="Perola">Markus Perola</name></country><country name="Finlande"><region name="Uusimaa"><name sortKey="Sarin, Antti Pekka" sort="Sarin, Antti Pekka" uniqKey="Sarin A" first="Antti-Pekka" last="Sarin">Antti-Pekka Sarin</name></region><name sortKey="Groop, Leif" sort="Groop, Leif" uniqKey="Groop L" first="Leif" last="Groop">Leif Groop</name><name sortKey="Hartikainen, Anna Liisa" sort="Hartikainen, Anna Liisa" uniqKey="Hartikainen A" first="Anna-Liisa" last="Hartikainen">Anna-Liisa Hartikainen</name><name sortKey="Havulinna, Aki S" sort="Havulinna, Aki S" uniqKey="Havulinna A" first="Aki S." last="Havulinna">Aki S. 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Savolainen</name><name sortKey="Shen, Huei Yi" sort="Shen, Huei Yi" uniqKey="Shen H" first="Huei-Yi" last="Shen">Huei-Yi Shen</name><name sortKey="Shen, Huei Yi" sort="Shen, Huei Yi" uniqKey="Shen H" first="Huei-Yi" last="Shen">Huei-Yi Shen</name><name sortKey="Taanila, Anja" sort="Taanila, Anja" uniqKey="Taanila A" first="Anja" last="Taanila">Anja Taanila</name><name sortKey="Tuomi, Tiinamaija" sort="Tuomi, Tiinamaija" uniqKey="Tuomi T" first="Tiinamaija" last="Tuomi">Tiinamaija Tuomi</name><name sortKey="Tuomi, Tiinamaija" sort="Tuomi, Tiinamaija" uniqKey="Tuomi T" first="Tiinamaija" last="Tuomi">Tiinamaija Tuomi</name><name sortKey="Vartiainen, Erkki" sort="Vartiainen, Erkki" uniqKey="Vartiainen E" first="Erkki" last="Vartiainen">Erkki Vartiainen</name><name sortKey="Virtamo, Jarmo" sort="Virtamo, Jarmo" uniqKey="Virtamo J" first="Jarmo" last="Virtamo">Jarmo Virtamo</name></country><country name="Islande"><noRegion><name sortKey="Thorleifsson, Gudmar" sort="Thorleifsson, Gudmar" uniqKey="Thorleifsson G" first="Gudmar" last="Thorleifsson">Gudmar Thorleifsson</name></noRegion><name sortKey="Gretarsdottir, Solveig" sort="Gretarsdottir, Solveig" uniqKey="Gretarsdottir S" first="Solveig" last="Gretarsdottir">Solveig Gretarsdottir</name><name sortKey="Holm, Hilma" sort="Holm, Hilma" uniqKey="Holm H" first="Hilma" last="Holm">Hilma Holm</name><name sortKey="Stefansson, Kari" sort="Stefansson, Kari" uniqKey="Stefansson K" first="Kari" last="Stefansson">Kari Stefansson</name><name sortKey="Stefansson, Kari" sort="Stefansson, Kari" uniqKey="Stefansson K" first="Kari" last="Stefansson">Kari Stefansson</name><name sortKey="Steinthorsdottir, Valgerdur" sort="Steinthorsdottir, Valgerdur" uniqKey="Steinthorsdottir V" first="Valgerdur" last="Steinthorsdottir">Valgerdur Steinthorsdottir</name><name sortKey="Thorsteinsdottir, Unnur" sort="Thorsteinsdottir, Unnur" uniqKey="Thorsteinsdottir U" first="Unnur" last="Thorsteinsdottir">Unnur Thorsteinsdottir</name><name sortKey="Thorsteinsdottir, Unnur" sort="Thorsteinsdottir, Unnur" uniqKey="Thorsteinsdottir U" first="Unnur" last="Thorsteinsdottir">Unnur Thorsteinsdottir</name></country><country name="Pays-Bas"><region name="Hollande-Méridionale"><name sortKey="Kuningas, Maris" sort="Kuningas, Maris" uniqKey="Kuningas M" first="Maris" last="Kuningas">Maris Kuningas</name></region><name sortKey="Amin, Najaf" sort="Amin, Najaf" uniqKey="Amin N" first="Najaf" last="Amin">Najaf Amin</name><name sortKey="Boomsma, Dorret I" sort="Boomsma, Dorret I" uniqKey="Boomsma D" first="Dorret I." last="Boomsma">Dorret I. 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Martin</name><name sortKey="Montgomery, Grant W" sort="Montgomery, Grant W" uniqKey="Montgomery G" first="Grant W." last="Montgomery">Grant W. Montgomery</name><name sortKey="Whitfield, John B" sort="Whitfield, John B" uniqKey="Whitfield J" first="John B." last="Whitfield">John B. Whitfield</name></country><country name="Italie"><region name="Lombardie"><name sortKey="Rivera, Natalia V" sort="Rivera, Natalia V" uniqKey="Rivera N" first="Natalia V." last="Rivera">Natalia V. Rivera</name></region><name sortKey="Brambilla, Paolo" sort="Brambilla, Paolo" uniqKey="Brambilla P" first="Paolo" last="Brambilla">Paolo Brambilla</name><name sortKey="Ferrario, Marco M" sort="Ferrario, Marco M" uniqKey="Ferrario M" first="Marco M." last="Ferrario">Marco M. Ferrario</name><name sortKey="Rivera, Natalia V" sort="Rivera, Natalia V" uniqKey="Rivera N" first="Natalia V." last="Rivera">Natalia V. Rivera</name></country><country name="Danemark"><noRegion><name sortKey="Lyssenko, Valeriya" sort="Lyssenko, Valeriya" uniqKey="Lyssenko V" first="Valeriya" last="Lyssenko">Valeriya Lyssenko</name></noRegion></country><country name="France"><region name="Occitanie (région administrative)"><name sortKey="Ferrieres, Jean" sort="Ferrieres, Jean" uniqKey="Ferrieres J" first="Jean" last="Ferrières">Jean Ferrières</name></region><name sortKey="Amouyel, Philippe" sort="Amouyel, Philippe" uniqKey="Amouyel P" first="Philippe" last="Amouyel">Philippe Amouyel</name><name sortKey="Arveiler, Dominique" sort="Arveiler, Dominique" uniqKey="Arveiler D" first="Dominique" last="Arveiler">Dominique Arveiler</name><name sortKey="Tregouet, David Alexandre" sort="Tregouet, David Alexandre" uniqKey="Tregouet D" first="David-Alexandre" last="Tregouet">David-Alexandre Tregouet</name></country><country name="États-Unis"><region name="Missouri (État)"><name sortKey="Heath, Andrew C" sort="Heath, Andrew C" uniqKey="Heath A" first="Andrew C." last="Heath">Andrew C. Heath</name></region><name sortKey="Madden, Pamela A F" sort="Madden, Pamela A F" uniqKey="Madden P" first="Pamela A. F." last="Madden">Pamela A. F. Madden</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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